Prostaciklinski receptor

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Prostaglandinski I2 (prostaciklinski) receptor (IP₁)

Identifikatori

PTGIR; MGC102830; PRIPR

Vanjski ID

OMIM: 600022 MGI: 99535 HomoloGene: 7496 IUPHAR: IP₁ GeneCards: PTGIR Gene

Ontologija gena
Molekularna funkcija	• rodopsinu-slična receptorska aktivnost • receptorska aktivnost • tromboksanska receptorska aktivnost
Celularna komponenta	• integralno sa ćelijskom membranom • membrana • integralno sa membranom
Biološki proces	• prenos signala • signalni put G-protein spregnutog receptora • G-protein signalizacija, spregnuta sa cikličnim nukleotidom kao sekundarnim glasnikom • ćelija-ćelija signalizacija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

5739

19222

Ensembl

ENSG00000160013

ENSMUSG00000043017

UniProt

P43119

Q3U4F1

RefSeq (mRNA)

NM_000960

NM_008967

RefSeq (protein)

NP_000951

NP_032993

Lokacija (UCSC)

Chr 19:
51.82 - 51.82 Mb

Chr 7:
16.07 - 16.07 Mb

PubMed pretraga

[1]

[2]

Prostaciklinski receptor (ili prostaglandinski I₂ receptor, IP₁) je receptor za prostaciklin.

On je član familije G-protein spregnutih receptora. Prostaciklin, glavni proizvod ciklooksigenaze u makrovaskularnom endotelu, uzrokuje potentnu vazodilataciju i inhibiciju agregacije trombocita putem vezivanja za ovaj receptor.^[1]

Transdukcija

Prilikom vezivanja za molekul prostaciklina, receptor konformaciju i aktivira G_s, koji aktivira cAMP i povećava aktivnost proteinske kinaze A (PKA).

Reference

↑ „Entrez Gene: PTGIR prostaglandin I2 (prostacyclin) receptor (IP)”.

Literatura

Coleman RA, Smith WL, Narumiya S (1994). „International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.”. Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.
Rauvala H, Peng HB (1997). „HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts.”. Prog. Neurobiol. 52 (2): 127–44. DOI:10.1016/S0301-0082(97)00007-5. PMID 9185236.
Smyth EM, FitzGerald GA (2003). „Human prostacyclin receptor.”. Vitam. Horm. 65: 149–65. DOI:10.1016/S0083-6729(02)65063-0. PMID 12481546.
Boie Y, Rushmore TH, Darmon-Goodwin A, et al. (1994). „Cloning and expression of a cDNA for the human prostanoid IP receptor.”. J. Biol. Chem. 269 (16): 12173–8. PMID 7512962.
Katsuyama M, Sugimoto Y, Namba T, et al. (1994). „Cloning and expression of a cDNA for the human prostacyclin receptor.”. FEBS Lett. 344 (1): 74–8. DOI:10.1016/0014-5793(94)00355-6. PMID 7514139.
Ogawa Y, Tanaka I, Inoue M, et al. (1995). „Structural organization and chromosomal assignment of the human prostacyclin receptor gene.”. Genomics 27 (1): 142–8. DOI:10.1006/geno.1995.1016. PMID 7665161.
Duncan AM, Anderson LL, Funk CD, et al. (1995). „Chromosomal localization of the human prostanoid receptor gene family.”. Genomics 25 (3): 740–2. DOI:10.1016/0888-7543(95)80022-E. PMID 7759114.
Nakagawa O, Tanaka I, Usui T, et al. (1994). „Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.”. Circulation 90 (4): 1643–7. PMID 7923647.
Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
Sasaki Y, Takahashi T, Tanaka I, et al. (1997). „Expression of prostacyclin receptor in human megakaryocytes.”. Blood 90 (3): 1039–46. PMID 9242534.
Fisch A, Tobusch K, Veit K, et al. (1997). „Prostacyclin receptor desensitization is a reversible phenomenon in human platelets.”. Circulation 96 (3): 756–60. PMID 9264479.
Smyth EM, Li WH, FitzGerald GA (1998). „Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.”. J. Biol. Chem. 273 (36): 23258–66. DOI:10.1074/jbc.273.36.23258. PMID 9722557.
Kömhoff M, Lesener B, Nakao K, et al. (1999). „Localization of the prostacyclin receptor in human kidney.”. Kidney Int. 54 (6): 1899–908. DOI:10.1046/j.1523-1755.1998.00213.x. PMID 9853255.
Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). „The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.”. J. Biol. Chem. 274 (34): 23707–18. DOI:10.1074/jbc.274.34.23707. PMID 10446129.
Smyth EM, Austin SC, Reilly MP, FitzGerald GA (2000). „Internalization and sequestration of the human prostacyclin receptor.”. J. Biol. Chem. 275 (41): 32037–45. DOI:10.1074/jbc.M003873200. PMID 10889200.
Lawler OA, Miggin SM, Kinsella BT (2001). „Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.”. J. Biol. Chem. 276 (36): 33596–607. DOI:10.1074/jbc.M104434200. PMID 11443126.
Zhang Z, Austin SC, Smyth EM (2001). „Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction.”. Mol. Pharmacol. 60 (3): 480–7. PMID 11502878.
Fortier I, Patry C, Lora M, et al. (2001). „Immunohistochemical localization of the prostacyclin receptor (IP) human bone.”. Prostaglandins Leukot. Essent. Fatty Acids 65 (2): 79–83. DOI:10.1054/plef.2001.0292. PMID 11545623.

Vidi još

Eikozanoidni receptor

Spoljašnje veze

„Prostanoid Receptors: IP₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

Transmembranski receptor: G protein spregnuti receptori

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Orfan

GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)

Drugi

Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4)

Klasa F:
Frizzled / Zaglađeni

Uvojiti	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni	Zaglađeni

B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)