Bradikininski receptor B2

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Bradikininski receptor B2
Identifikatori
SimboliBDKRB2; B2R; BK-2; BK2; BKR2; BRB2; DKFZp686O088
Vanjski IDOMIM: 113503 MGI: 102845 HomoloGene: 519 IUPHAR: B2 GeneCards: BDKRB2 Gene
Ontologija gena
Molekularna funkcija • rodopsinu-slična receptorska aktivnost
• aktivnost fosfoinozitid fosfolipaze C
• receptorska aktivnost
• aktivnost bradikininskog receptora
Celularna komponenta • ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • kontrakcija glatkih mišića
• inflamatorni respons
• signalni put tirozinske kinaze
• signalni put G-protein spregnutog receptora
• elevacija citosolne koncentracije jona kalcijuma
• senzorna percepcija
• cirkulacija
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez62412062
EnsemblENSG00000168398ENSMUSG00000021070
UniProtP30411P32299
RefSeq (mRNA)NM_000623NM_009747
RefSeq (protein)NP_000614NP_033877
Lokacija (UCSC)Chr 14:
95.74 - 95.78 Mb		Chr 12:
105.96 - 105.99 Mb
PubMed pretraga[1][2]

Bradikininski receptor B2 je G-protein spregnuti receptor bradikinina. Njega kodira BDKRB2 gen kod čoveka.

Mehanizam

B2 receptor je G protein-spregnuti receptor. Pretpostavlja se da je spregnut sa Gq, dok Gi. Gq stimuliše fosfolipazu C i povišava koncentraciju Intracelularnog slobodnog kalcijuma i Gi inhibira adenilat ciklazu. Pored toga, receptor stimuliše puteve mitogenom-aktiviranih proteinskih kinaza. On je široko rasprostranjen i konstitutivno izražen u zdravim tkivima.

B2 receptor formira kompleks sa angiotenzin konvertujućim enzimom (ACE), i stoga se smatra da učestvuje u razmeni informacija između renin-angiotenzinskog sistema (RAS) i kinin-kalikreinskog sistema (KKS). Heptapeptid angiotenzin 1-7 (A1-7) takođe pojačava dejstvo bradikinina na B2 receptore.[1]

Kalidin takođe dejstvuje kroz B2 receptor.

Funkcija

Bradikinin je peptid sa 9 aminokiselina koji proizvodi mnogobrojne response kao što su vazodilatacija, edemi i spazam glatkih mišića.

Vidi još

Bradikininski receptor

Reference

  1. ↑ Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH (2001). „Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo”. Hypertension 37 (2 Part 2): 703–9. PMID 11230360. 

Literatura

  • Duchêne J, Schanstra J, Cellier E, et al. (2002). „[30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway]”. Néphrologie 23 (1): 39–41. PMID 11908480. 
  • Ariza AC, Bobadilla NA, Halhali A (2007). „[Endothelin 1 and angiotensin II in preeeclampsia]”. Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300. 
  • Hess JF, Borkowski JA, Young GS, et al. (1992). „Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor.”. Biochem. Biophys. Res. Commun. 184 (1): 260–8. DOI:10.1016/0006-291X(92)91187-U. PMID 1314587. 
  • Eggerickx D, Raspe E, Bertrand D, et al. (1992). „Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene.”. Biochem. Biophys. Res. Commun. 187 (3): 1306–13. DOI:10.1016/0006-291X(92)90445-Q. PMID 1329734. 
  • Kammerer S, Braun A, Arnold N, Roscher AA (1995). „The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region.”. Biochem. Biophys. Res. Commun. 211 (1): 226–33. DOI:10.1006/bbrc.1995.1800. PMID 7779089. 
  • Braun A, Kammerer S, Böhme E, et al. (1995). „Identification of polymorphic sites of the human bradykinin B2 receptor gene.”. Biochem. Biophys. Res. Commun. 211 (1): 234–40. DOI:10.1006/bbrc.1995.1801. PMID 7779090. 
  • Ma JX, Wang DZ, Ward DC, et al. (1995). „Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor.”. Genomics 23 (2): 362–9. DOI:10.1006/geno.1994.1512. PMID 7835885. 
  • Powell SJ, Slynn G, Thomas C, et al. (1993). „Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14.”. Genomics 15 (2): 435–8. DOI:10.1006/geno.1993.1084. PMID 7916737. 
  • Menke JG, Borkowski JA, Bierilo KK, et al. (1994). „Expression cloning of a human B1 bradykinin receptor.”. J. Biol. Chem. 269 (34): 21583–6. PMID 8063797. 
  • Hess JF, Borkowski JA, Macneil T, et al. (1994). „Differential pharmacology of cloned human and mouse B2 bradykinin receptors.”. Mol. Pharmacol. 45 (1): 1–8. PMID 8302267. 
  • McIntyre P, Phillips E, Skidmore E, et al. (1993). „Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity.”. Mol. Pharmacol. 44 (2): 346–55. PMID 8394991. 
  • AbdAlla S, Godovac-Zimmermann J, Braun A, et al. (1996). „Structure of the bradykinin B2 receptors' amino terminus.”. Biochemistry 35 (23): 7514–9. DOI:10.1021/bi9601060. PMID 8652530. 
  • Isami S, Kishikawa H, Araki E, et al. (1996). „Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway.”. Diabetologia 39 (4): 412–20. DOI:10.1007/BF00400672. PMID 8777990. 
  • Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL (1996). „Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms.”. Eur. J. Cell Biol. 69 (3): 236–44. PMID 8900488. 
  • Soskic V, Nyakatura E, Roos M, et al. (1999). „Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells.”. J. Biol. Chem. 274 (13): 8539–45. DOI:10.1074/jbc.274.13.8539. PMID 10085087. 
  • Cassano G, Susca F, Lippe C, Guanti G (1999). „Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts.”. Gen. Pharmacol. 32 (2): 239–44. DOI:10.1016/S0306-3623(98)00275-4. PMID 10188626. 
  • Efremov R, Truong MJ, Darcissac EC, et al. (1999). „Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function.”. Eur. J. Biochem. 263 (3): 746–56. DOI:10.1046/j.1432-1327.1999.00553.x. PMID 10469138. 
  • Marrero MB, Venema VJ, Ju H, et al. (1999). „Endothelial nitric oxide synthase interactions with G-protein-coupled receptors.”. Biochem. J. 343 Pt 2: 335–40. DOI:10.1042/0264-6021:3430335. PMC 1220558. PMID 10510297. 
  • Reyes-Cruz G, Vázquez-Prado J, Müller-Esterl W, Vaca L (2000). „Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases.”. J. Cell. Biochem. 76 (4): 658–73. DOI:10.1002/(SICI)1097-4644(20000315)76:4<658::AID-JCB14>3.0.CO;2-7. PMID 10653985. 
  • Golser R, Gorren AC, Leber A, et al. (2000). „Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation.”. J. Biol. Chem. 275 (8): 5291–6. DOI:10.1074/jbc.275.8.5291. PMID 10681501. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Neuropeptidni receptori
Hormonski receptori
Drugi
Opioidni receptori
Drugi neuropeptidni receptori
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)