Eikozanoidni receptor

Eikozanoidni receptor je integralni membranski protein koji detektuje prisustvo eikozanoidnih signalnih molekula. Većina, mada ne svi, su G protein spregnuti receptori. Primer ne-GPCR receptora koji vezuje eikozanoide je PPAR-γ.[1]

Ovo su poznati humani eikozanoidni GPCR receptori grupisani po tipu eikozanoidnog liganda koji vezuju:[2][3]

Leukotrien

Leukotrieni:

  • CysLT1 (Cisteinil leukotrienski receptor 1) - CYSLTR1
  • CysLT2 (Cisteinil leukotrienski receptor 2) - CYSLTR2
  • BLT1 (Leukotrienski B4 receptor) - LTB4R
  • BLT2 (Leukotrienski B4 receptor 2) - LTB4R2

Lipoksin

Lipoksini:

  • LXA4R (Formil peptidnom receptoru-sličan 1) - FPRL1

Oksoeikozanoid

Oksoeikozanoid:[4]

  • Oksoeikozanoidni (OXE) receptor 1 - OXER1

Prostanoid

Prostanoidi:

  • PGD2: DP-(PGD2)
    • DP1 (Prostaglandin D2 receptor) - PTGDR
    • DP2 (GPR44) - GPR44
  • PGE2:
    • EP1-(PGE2) (PTGER1) - PTGER1
    • EP2-(PGE2) (PTGER2) - PTGER2
    • EP3-(PGE2) (PTGER3) - PTGER3
    • EP4-(PGE2) (PTGER4) - PTGER4
  • PGF2α: FP-(PGF2α) (PTGFR) - PTGFR
  • PGI2 (prostaciklin): IP-(PGI2) (PTGIR) - PTGIR
  • TXA2 (tromboksan): TP-(TXA2) (TBXA2R) - TBXA2R

Reference

  1. ↑ DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA (1998). „The nuclear eicosanoid receptor, PPAR-γ, is aberrantly expressed in colonic cancers”. Carcinogenesis 19 (1): 49–53. DOI:10.1093/carcin/19.1.49. PMID 9472692. 
  2. ↑ Coleman RA, Smith WL, Narumiya S (1994). „International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes”. Pharmacol. Rev. 46 (2): 205–29. PMID 7938166. 
  3. ↑ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003). „International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors”. Pharmacol. Rev. 55 (1): 195–227. DOI:10.1124/pr.55.1.8. PMID 12615958. 
  4. ↑ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). „International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor”. Pharmacol. Rev. 56 (1): 149–57. DOI:10.1124/pr.56.1.4. PMID 15001665. 

Spoljašnje veze

  • „Leukotriene Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
  • „Prostanoid Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2021-04-15. 
  • MeSH Eicosanoid+receptors
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
Eikozanoidni
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)