Pankreasni polipeptidni receptor 1
| edit |
| Pankreasni polipeptidni receptor 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | PPYR1; PP1; MGC116897; NPY4-R; NPY4R; Y4 | ||||||||||
| Vanjski ID | OMIM: 601790 MGI: 105374 HomoloGene: 38119 IUPHAR: Y4 GeneCards: PPYR1 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5540 | 19065 | |||||||||
| Ensembl | ENSG00000204174 | ENSMUSG00000048337 | |||||||||
| UniProt | P50391 | Q3UN46 | |||||||||
| RefSeq (mRNA) | XM_001129329 | NM_008919 | |||||||||
| RefSeq (protein) | XP_001129329 | NP_032945 | |||||||||
| Lokacija (UCSC) | Chr 10: 46.5 - 46.51 Mb | Chr 14: 32.97 - 32.98 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Neuropeptidni Y receptor tip 4 je protein koji je kod čoveka kodiran PPYR1 genom.[1][2]
Selektivni ligandi
Agonisti
- Pankreasni polipeptid
- Neuropeptid Y (endogeni agonist, nije selektivan za NPY4R podtip)
- Peptid YY
- GR-231,118 (mešoviti NPY1 antagonist / NPY4 agonist)
Antagonisti
- UR-AK49[3]
Vidi još
- Neuropeptidni Y receptor
Literatura
- ↑ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Feb 1998). „Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY”. Genomics 46 (2): 287–90. DOI:10.1006/geno.1997.5024. PMID 9417917.
- ↑ „Entrez Gene: PPYR1 pancreatic polypeptide receptor 1”.
- ↑ Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). „Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence”. Journal of Receptor and Signal Transduction Research 27 (4): 217–33. DOI:10.1080/10799890701505206. PMID 17885919.
Dodatna literatura
- Keire DA, Bowers CW, Solomon TE, Reeve JR (2002). „Structure and receptor binding of PYY analogs.”. Peptides 23 (2): 305–21. DOI:10.1016/S0196-9781(01)00602-7. PMID 11825645.
- Balasubramaniam A (2002). „Clinical potentials of neuropeptide Y family of hormones.”. Am. J. Surg. 183 (4): 430–4. DOI:10.1016/S0002-9610(02)00803-6. PMID 11975932.
- Parker E, Van Heek M, Stamford A (2002). „Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.”. Eur. J. Pharmacol. 440 (2-3): 173–87. DOI:10.1016/S0014-2999(02)01427-9. PMID 12007534.
- Benaim G, Villalobo A (2002). „Phosphorylation of calmodulin. Functional implications.”. Eur. J. Biochem. 269 (15): 3619–31. DOI:10.1046/j.1432-1033.2002.03038.x. PMID 12153558.
- Lundell I, Blomqvist AG, Berglund MM, et al. (1996). „Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.”. J. Biol. Chem. 270 (49): 29123–8. DOI:10.1074/jbc.270.49.29123. PMID 7493937.
- Bard JA, Walker MW, Branchek TA, Weinshank RL (1995). „Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.”. J. Biol. Chem. 270 (45): 26762–5. DOI:10.1074/jbc.270.45.26762. PMID 7592911.
- Yan H, Yang J, Marasco J, et al. (1996). „Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.”. Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4661–5. DOI:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460.
- Kawabe T, Muslin AJ, Korsmeyer SJ (1997). „HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.”. Nature 385 (6615): 454–8. DOI:10.1038/385454a0. PMID 9009195.
- Darby K, Eyre HJ, Lapsys N, et al. (1998). „Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14.”. Genomics 46 (3): 513–5. DOI:10.1006/geno.1997.5071. PMID 9441761.
- Hsieh-Wilson LC, Allen PB, Watanabe T, et al. (1999). „Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.”. Biochemistry 38 (14): 4365–73. DOI:10.1021/bi982900m. PMID 10194355.
- Smith FD, Oxford GS, Milgram SL (1999). „Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein.”. J. Biol. Chem. 274 (28): 19894–900. DOI:10.1074/jbc.274.28.19894. PMID 10391935.
- Marx SO, Reiken S, Hisamatsu Y, et al. (2000). „PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.”. Cell 101 (4): 365–76. DOI:10.1016/S0092-8674(00)80847-8. PMID 10830164.
- Connor JH, Weiser DC, Li S, et al. (2001). „Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.”. Mol. Cell. Biol. 21 (20): 6841–50. DOI:10.1128/MCB.21.20.6841-6850.2001. PMC 99861. PMID 11564868.
- Cavadas C, Silva AP, Mosimann F, et al. (2001). „NPY regulates catecholamine secretion from human adrenal chromaffin cells.”. J. Clin. Endocrinol. Metab. 86 (12): 5956–63. DOI:10.1210/jc.86.12.5956. PMID 11739470.
- Cox HM, Tough IR (2002). „Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.”. Br. J. Pharmacol. 135 (6): 1505–12. DOI:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
- Wu DY, Tkachuck DC, Roberson RS, Schubach WH (2002). „The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.”. J. Biol. Chem. 277 (31): 27706–15. DOI:10.1074/jbc.M200955200. PMID 12016208.
Spoljašnje veze
- „Neuropeptide Y Receptors: Y4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
- p
- r
- u
Drugi | Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2) |
|---|
glutamat / feromon
Drugi |
|---|
Frizzled / Zaglađeni
Uvojiti | |
|---|---|
Zaglađeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
