GPR56

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G protein spregnuti receptor 56
Identifikatori
SimboliGPR56; BFPP; TM7LN4; TM7XN1
Vanjski IDOMIM: 604110 MGI: 1340051 HomoloGene: 4156 IUPHAR: GPR56 GeneCards: GPR56 Gene
Ontologija gena
Molekularna funkcija • aktivnost G protein spregnutog receptora
Celularna komponenta • integralno sa ćelijskom membranom
• integralno sa membranom
Biološki proces • ćelijska adhezija
• signalni put G protein spregnutog receptora
• neuropeptidni signalni put
• međućelijska signalizacija
• moždani razvoj
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez928914766
EnsemblENSG00000205336ENSMUSG00000031785
UniProtQ9Y653Q8K209
RefSeq (mRNA)NM_001145770.1NM_001198894.1
RefSeq (protein)NP_001139242.1NP_001185823.1
Lokacija (UCSC)Chr 16:
57.64 - 57.7 Mb		Chr 8:
97.51 - 97.54 Mb
PubMed pretraga[1][2]

G protein spregnuti receptor 56 je protein koji je kod ljudi kodiran GPR56 genom.[1][2][3]

Izražavanje GPR56 gena u melanocitnim ćelijama je regulisano MITF faktorom.[4]

Reference

  1. ↑ Liu M, Parker RM, Darby K, Eyre HJ, Copeland NG, Crawford J, Gilbert DJ, Sutherland GR, Jenkins NA, Herzog H (May 1999). „GPR56, a novel secretin-like human G-protein-coupled receptor gene”. Genomics 55 (3): 296–305. DOI:10.1006/geno.1998.5644. PMID 10049584. 
  2. ↑ Zendman AJ, Cornelissen IM, Weidle UH, Ruiter DJ, van Muijen GN (Apr 1999). „TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA differential display using human melanoma cell lines with different metastatic potential”. FEBS Lett 446 (2-3): 292–8. DOI:10.1016/S0014-5793(99)00230-6. PMID 10100861. 
  3. ↑ „Entrez Gene: GPR56 G protein-coupled receptor 56”. 
  4. ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). „Novel MITF targets identified using a two-step DNA microarray strategy”. Pigment Cell Melanoma Res. 21 (6): 665–76. DOI:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

Literatura

  • Xu L, Hynes RO (2007). „GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment.”. Cell Cycle 6 (2): 160–5. DOI:10.4161/cc.6.2.3760. PMID 17314516. 
  • Piao X, Basel-Vanagaite L, Straussberg R, et al. (2002). „An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21.”. Am. J. Hum. Genet. 70 (4): 1028–33. DOI:10.1086/339552. PMC 379097. PMID 11845408. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). „The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”. Genome Res. 13 (10): 2265–70. DOI:10.1101/gr.1293003. PMC 403697. PMID 12975309. 
  • Little KD, Hemler ME, Stipp CS (2005). „Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association.”. Mol. Biol. Cell 15 (5): 2375–87. DOI:10.1091/mbc.E03-12-0886. PMC 404030. PMID 15004227. 
  • Piao X, Hill RS, Bodell A, et al. (2004). „G protein-coupled receptor-dependent development of human frontal cortex.”. Science 303 (5666): 2033–6. DOI:10.1126/science.1092780. PMID 15044805. 
  • Zhang Z, Henzel WJ (2005). „Signal peptide prediction based on analysis of experimentally verified cleavage sites.”. Protein Sci. 13 (10): 2819–24. DOI:10.1110/ps.04682504. PMC 2286551. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Shashidhar S, Lorente G, Nagavarapu U, et al. (2005). „GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion.”. Oncogene 24 (10): 1673–82. DOI:10.1038/sj.onc.1208395. PMID 15674329. 
  • Sud N, Sharma R, Ray R, et al. (2006). „Differential expression of G-protein coupled receptor 56 in human esophageal squamous cell carcinoma.”. Cancer Lett. 233 (2): 265–70. DOI:10.1016/j.canlet.2005.03.018. PMID 15916848. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”. DNA Res. 12 (2): 117–26. DOI:10.1093/dnares/12.2.117. PMID 16303743. 
  • Xu L, Begum S, Hearn JD, Hynes RO (2006). „GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.”. Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9023–8. DOI:10.1073/pnas.0602681103. PMC 1474142. PMID 16757564. 

Spoljašnje veze

  • GeneReviews/NIH/NCBI/UW entry on Polymicrogyria Overview
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)