Bradikininski receptor B1

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Bradikininski receptor B1
Identifikatori
SimboliBDKRB1; B1BKR; B1R; BKB1R; BKR1; BRADYB1
Vanjski IDOMIM: 600337 MGI: 88144 HomoloGene: 570 IUPHAR: B1 GeneCards: BDKRB1 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• receptorska aktivnost
• aktivnost bradikininskog receptora
Celularna komponenta • endoplazmatični retikulum
• ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • inflamatorni respons
• prenos signala
• signalni put G-protein spregnutog receptora
• elevacija koncentracije citosolnih jona kalcijuma
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez62312061
EnsemblENSG00000100739ENSMUSG00000041347
UniProtP46663Q0VBD7
RefSeq (mRNA)NM_000710NM_007539
RefSeq (protein)NP_000701NP_031565
Lokacija (UCSC)Chr 14:
95.8 - 95.8 Mb		Chr 12:
106.01 - 106.01 Mb
PubMed pretraga[1][2]

Bradikininski receptor B1 (B1) je G-protein spregnuti receptor kodiran BDKRB1 genom kod ljudi. Njegov principalni ligand je bradikinin, peptid sa 9 aminokiselina koji se formira u patofiziološkim uslovima kao što je inflamacija, trauma, opekotine, šok, i alergija. B1 receptor je jedan od dva G protein-spregnuta receptora za koje je utvrđeno da vezuju bradikinin i posreduju response na te patofiziološke uslove.

B1 protein se sintetiše de novo nakon povrede tkiva. Njegovo vezivanje za receptor dovodi do povećanja citosolne koncentracije jona kalcijuma, što ultimatno dovodi do hroničnog i akutnog inflamatornog responsa.[1]

Reference

  1. ↑ „Entrez Gene: BDKRB1 bradykinin receptor B1”. 

Literatura

  • Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A (2007). „A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5.”. J. Immunol. 179 (7): 4849–56. PMID 17878384. 
  • Calixto JB, Medeiros R, Fernandes ES, et al. (2005). „Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes.”. Br. J. Pharmacol. 143 (7): 803–18. DOI:10.1038/sj.bjp.0706012. PMC 1575942. PMID 15520046. 
  • Menke JG, Borkowski JA, Bierilo KK, et al. (1994). „Expression cloning of a human B1 bradykinin receptor.”. J. Biol. Chem. 269 (34): 21583–6. PMID 8063797. 
  • Yang X, Polgar P (1996). „Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions.”. Biochem. Biophys. Res. Commun. 222 (3): 718–25. DOI:10.1006/bbrc.1996.0810. PMID 8651911. 
  • Bachvarov DR, Hess JF, Menke JG, et al. (1996). „Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1).”. Genomics 33 (3): 374–81. DOI:10.1006/geno.1996.0213. PMID 8660997. 
  • Chai KX, Ni A, Wang D, et al. (1996). „Genomic DNA sequence, expression, and chromosomal localization of the human B1 bradykinin receptor gene BDKRB1.”. Genomics 31 (1): 51–7. DOI:10.1006/geno.1996.0008. PMID 8808279. 
  • Leeb T, Mathis SA, Leeb-Lundberg LM (1997). „The sixth transmembrane domains of the human B1 and B2 bradykinin receptors are structurally compatible and involved in discriminating between subtype-selective agonists.”. J. Biol. Chem. 272 (1): 311–7. DOI:10.1074/jbc.272.1.311. PMID 8995263. 
  • Blaukat A, Herzer K, Schroeder C, et al. (1999). „Overexpression and functional characterization of kinin receptors reveal subtype-specific phosphorylation.”. Biochemistry 38 (4): 1300–9. DOI:10.1021/bi981727r. PMID 9930991. 
  • Cassano G, Susca F, Lippe C, Guanti G (1999). „Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts.”. Gen. Pharmacol. 32 (2): 239–44. DOI:10.1016/S0306-3623(98)00275-4. PMID 10188626. 
  • Zhou X, Prado GN, Chai M, et al. (2000). „Posttranscriptional destabilization of the bradykinin B1 receptor messenger RNA: cloning and functional characterization of the 3'-untranslated region.”. Mol. Cell Biol. Res. Commun. 1 (1): 29–35. DOI:10.1006/mcbr.1999.0105. PMID 10329474. 
  • Jones C, Phillips E, Davis C, et al. (1999). „Molecular characterisation of cloned bradykinin B1 receptors from rat and human.”. Eur. J. Pharmacol. 374 (3): 423–33. DOI:10.1016/S0014-2999(99)00315-5. PMID 10422787. 
  • Sjuve R, Boels PJ, Uvelius B, Arner A (2000). „Up-regulation of bradykinin response in rat and human bladder smooth muscle.”. J. Urol. 164 (5): 1757–63. DOI:10.1016/S0022-5347(05)67102-9. PMID 11025765. 
  • Sawant S, Snyman C, Bhoola K (2002). „Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms.”. Int. Immunopharmacol. 1 (12): 2063–80. DOI:10.1016/S1567-5769(01)00118-7. PMID 11710536. 
  • Ignjatovic T, Tan F, Brovkovych V, et al. (2002). „Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.”. J. Biol. Chem. 277 (19): 16847–52. DOI:10.1074/jbc.M200355200. PMID 11880373. 
  • Newton R, Eddleston J, Haddad el-B, et al. (2002). „Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone.”. Eur. J. Pharmacol. 441 (3): 193–202. DOI:10.1016/S0014-2999(01)01624-7. PMID 12063092. 
  • Kang DS, Leeb-Lundberg LM (2002). „Negative and positive regulatory epitopes in the C-terminal domains of the human B1 and B2 bradykinin receptor subtypes determine receptor coupling efficacy to G(q/11)-mediated [correction of G(9/11)-mediated] phospholipase Cbeta activity.”. Mol. Pharmacol. 62 (2): 281–8. DOI:10.1124/mol.62.2.281. PMID 12130679. 
  • Christiansen SC, Eddleston J, Woessner KM, et al. (2002). „Up-regulation of functional kinin B1 receptors in allergic airway inflammation.”. J. Immunol. 169 (4): 2054–60. PMID 12165532. 
  • Lamb ME, Zhang C, Shea T, et al. (2003). „Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells.”. Biochemistry 41 (48): 14340–7. DOI:10.1021/bi020231d. PMID 12450400. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Kang DS, Ryberg K, Mörgelin M, Leeb-Lundberg LM (2004). „Spontaneous formation of a proteolytic B1 and B2 bradykinin receptor complex with enhanced signaling capacity.”. J. Biol. Chem. 279 (21): 22102–7. DOI:10.1074/jbc.M402572200. PMID 15033977. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 

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Spoljašnje veze

  • „Bradykinin Receptors: B1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Neuropeptidni receptori
Hormonski receptori
Drugi
Opioidni receptori
Drugi neuropeptidni receptori
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)