Urotenzin-II receptor

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Urotenzin 2 receptor
Identifikatori
SimboliUTS2R; GPR14; UTR; UTR2
Vanjski IDOMIM: 600896 MGI: 2183450 HomoloGene: 10345 IUPHAR: UT GeneCards: UTS2R Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• aktivnost urotenzin II receptora
• aktivnost receptora
Celularna komponenta • membrana
• integralno sa membranom
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• cirkculacija
Ortolozi
VrstaČovekMiš
Entrez2837217369
EnsemblENSG00000181408ENSMUSG00000039321
UniProtQ9UKP6Q05AD1
RefSeq (mRNA)NM_018949NM_145440
RefSeq (protein)NP_061822NP_663415
Lokacija (UCSC)Chr 17:
77.93 - 77.93 Mb		Chr 11:
120.98 - 120.98 Mb
PubMed pretraga[1][2]

Urotenzin-II receptor (UT, hipokretinski receptor) je G-protein spregnuti receptor koji vezuje peptidni hormon urotenzin-II.[1]

Literatura

  1. ↑ Douglas SA, Dhanak D, Johns DG (2004). „From 'gills to pills': urotensin-II as a regulator of mammalian cardiorenal function”. Trends Pharmacol. Sci. 25 (2): 76–85. DOI:10.1016/j.tips.2003.12.005. PMID 15102493. 

Dodatna literatura

  • Marchese A, Heiber M, Nguyen T, et al. (1996). „Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.”. Genomics 29 (2): 335–44. DOI:10.1006/geno.1995.9996. PMID 8666380. 
  • Coulouarn Y, Lihrmann I, Jegou S, et al. (1999). „Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord.”. Proc. Natl. Acad. Sci. U.S.A. 95 (26): 15803–8. DOI:10.1073/pnas.95.26.15803. PMC 28125. PMID 9861051. 
  • Ames RS, Sarau HM, Chambers JK, et al. (1999). „Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.”. Nature 401 (6750): 282–6. DOI:10.1038/45809. PMID 10499587. 
  • Liu Q, Pong SS, Zeng Z, et al. (2000). „Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14.”. Biochem. Biophys. Res. Commun. 266 (1): 174–8. DOI:10.1006/bbrc.1999.1796. PMID 10581185. 
  • Protopopov A, Kashuba V, Podowski R, et al. (2000). „Assignment of the GPR14 gene coding for the G-protein-coupled receptor 14 to human chromosome 17q25.3 by fluorescent in situ hybridization.”. Cytogenet. Cell Genet. 88 (3-4): 312–3. DOI:10.1159/000015516. PMID 10828617. 
  • Maguire JJ, Kuc RE, Davenport AP (2001). „Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1.”. Br. J. Pharmacol. 131 (3): 441–6. DOI:10.1038/sj.bjp.0703601. PMC 1572358. PMID 11015293. 
  • Sugo T, Murakami Y, Shimomura Y, et al. (2003). „Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain.”. Biochem. Biophys. Res. Commun. 310 (3): 860–8. DOI:10.1016/j.bbrc.2003.09.102. PMID 14550283. 
  • Birker-Robaczewska M, Boukhadra C, Studer R, et al. (2004). „The expression of urotensin II receptor (U2R) is up-regulated by interferon-gamma.”. J. Recept. Signal Transduct. Res. 23 (4): 289–305. DOI:10.1081/RRS-120026972. PMID 14753294. 
  • Bousette N, Patel L, Douglas SA, et al. (2004). „Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta.”. Atherosclerosis 176 (1): 117–23. DOI:10.1016/j.atherosclerosis.2004.03.023. PMID 15306183. 
  • Suzuki S, Wenyi Z, Hirai M, et al. (2005). „Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese.”. Peptides 25 (10): 1803–8. DOI:10.1016/j.peptides.2004.03.030. PMID 15476949. 
  • Qi JS, Minor LK, Smith C, et al. (2005). „Characterization of functional urotensin II receptors in human skeletal muscle myoblasts: comparison with angiotensin II receptors.”. Peptides 26 (4): 683–90. DOI:10.1016/j.peptides.2004.11.018. PMID 15752584. 
  • Lehner U, Velić A, Schroter R, et al. (2007). „Ligands and signaling of the G-protein-coupled receptor GPR14, expressed in human kidney cells.”. Cell. Physiol. Biochem. 20 (1-4): 181–92. DOI:10.1159/000104165. PMID 17595527. 
  • Segain JP, Rolli-Derkinderen M, Gervois N, et al. (2007). „Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes.”. J. Immunol. 179 (2): 901–9. PMID 17617581. 
  • Lehmann F, Pettersen A, Currier EA, Sherbukin, V, Olsson R, Hacksell U, Luthman K (2006). „Novel potent and efficacious Urotensin II receptor agonists.”. J. Med. Chem 49 (7): 2232–40. DOI:10.1021/jm051121i. PMID 16570919. 

Spoljašnje veze

  • „Urotensin Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
  • MeSH UTS2R+protein,+human
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)