Somatostatinski receptor 2

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Somatostatinski receptor 2
Identifikatori
SimboliSSTR2;
Vanjski IDOMIM: 182452 MGI: 98328 HomoloGene: 37427 IUPHAR: sst2 GeneCards: SSTR2 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• receptorska aktivnost
• aktivnost somatostatinskog receptora
• proteinsko vezivanje
• vezivanje za PDZ domen
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
• integralno sa ćelijskom membranom
Biološki proces • prenos signala
• G-proteinska signalizacija, spregnuta sa ciklično nukleotidnim sekundarnim glasnikom
• G-proteinska signalizacija, inhibicioni put adenilat ciklaze
• neuropeptidni signalni put
• interćelijska signalizacija
• respons na hranu
• varenje
• negativna regulacija ćelijske proliferacije
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez675220606
EnsemblENSG00000180616ENSMUSG00000047904
UniProtP30874P30875
RefSeq (mRNA)NM_001050NM_009217
RefSeq (protein)NP_001041NP_033243
Lokacija (UCSC)Chr 17:
68.67 - 68.68 Mb		Chr 11:
113.44 - 113.44 Mb
PubMed pretraga[1][2]

Somatostatinski receptor tip 2 je protein koji je kod čoveka kodiran SSTR2 genom..[1]

Somatostatin deluje na mnogim lokacijama i inhibira oslobađanje hormona i drugih sekretornih proteina. Biološki efekti somatostatina su posredovani familijom G protein-spregnutih receptora čije izražavanje je specifično za pojedina tkiva. SSTR2 u znatnoj meri izražen u velikom mozgu i bubrezima.[2]

Interakcije

Za somatostatinski receptor 2 je pokazano interaguje sa SHANK2.[3]

Vidi isto

  • Somatostatinski receptor

Reference

  1. ↑ Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (Apr 1993). „Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms”. Genomics 15 (2): 449–52. DOI:10.1006/geno.1993.1088. PMID 8449518. 
  2. ↑ „Entrez Gene: SSTR2 somatostatin receptor 2”. 
  3. ↑ Zitzer, H; Hönck H H, Bächner D, Richter D, Kreienkamp H J (Nov 1999). „Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain”. J. Biol. Chem. (UNITED STATES) 274 (46): 32997–3001. DOI:10.1074/jbc.274.46.32997. ISSN 0021-9258. PMID 10551867. 

Literatura

  • Yamada Y, Post SR, Wang K, et al. (1992). „Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.”. Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. DOI:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068. 
  • Reubi JC, Waser B, Schaer JC, Markwalder R (1995). „Somatostatin receptors in human prostate and prostate cancer.”. J. Clin. Endocrinol. Metab. 80 (9): 2806–14. DOI:10.1210/jc.80.9.2806. PMID 7673428. 
  • Kagimoto S, Yamada Y, Kubota A, et al. (1994). „Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.”. Biochem. Biophys. Res. Commun. 202 (2): 1188–95. DOI:10.1006/bbrc.1994.2054. PMID 7914078. 
  • Fujita T, Yamaji Y, Sato M, et al. (1994). „Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines.”. Life Sci. 55 (23): 1797–806. DOI:10.1016/0024-3205(94)90090-6. PMID 7968260. 
  • Patel YC, Greenwood M, Kent G, et al. (1993). „Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.”. Biochem. Biophys. Res. Commun. 192 (1): 288–94. DOI:10.1006/bbrc.1993.1412. PMID 8386508. 
  • Fukusumi S, Kitada C, Takekawa S, et al. (1997). „Identification and characterization of a novel human cortistatin-like peptide.”. Biochem. Biophys. Res. Commun. 232 (1): 157–63. DOI:10.1006/bbrc.1997.6252. PMID 9125122. 
  • Jaïs P, Terris B, Ruszniewski P, et al. (1997). „Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.”. Eur. J. Clin. Invest. 27 (8): 639–44. DOI:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. 
  • Lopez F, Estève JP, Buscail L, et al. (1997). „The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling.”. J. Biol. Chem. 272 (39): 24448–54. DOI:10.1074/jbc.272.39.24448. PMID 9305905. 
  • Tsutsumi A, Takano H, Ichikawa K, et al. (1997). „Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells.”. Cell. Immunol. 181 (1): 44–9. DOI:10.1006/cimm.1997.1193. PMID 9344495. 
  • Sharma K, Patel YC, Srikant CB (1999). „C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.”. Mol. Endocrinol. 13 (1): 82–90. DOI:10.1210/me.13.1.82. PMID 9892014. 
  • Kumar U, Sasi R, Suresh S, et al. (1999). „Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.”. Diabetes 48 (1): 77–85. DOI:10.2337/diabetes.48.1.77. PMID 9892225. 
  • Zitzer H, Richter D, Kreienkamp HJ (1999). „Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1.”. J. Biol. Chem. 274 (26): 18153–6. DOI:10.1074/jbc.274.26.18153. PMID 10373412. 
  • Zitzer H, Hönck HH, Bächner D, et al. (2000). „Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.”. J. Biol. Chem. 274 (46): 32997–3001. DOI:10.1074/jbc.274.46.32997. PMID 10551867. 
  • Petersenn S, Rasch AC, Presch S, et al. (2000). „Genomic structure and transcriptional regulation of the human somatostatin receptor type 2.”. Mol. Cell. Endocrinol. 157 (1-2): 75–85. DOI:10.1016/S0303-7207(99)00161-6. PMID 10619399. 
  • Kreienkamp HJ, Zitzer H, Richter D (2001). „Identification of proteins interacting with the rat somatostatin receptor subtype 2.”. J. Physiol. Paris 94 (3-4): 193–8. DOI:10.1016/S0928-4257(00)00204-7. PMID 11087996. 
  • Ho MK, Yung LY, Chan JS, et al. (2001). „Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C.”. Br. J. Pharmacol. 132 (7): 1431–40. DOI:10.1038/sj.bjp.0703933. PMC 1572686. PMID 11264236. 
  • Zatelli MC, Tagliati F, Taylor JE, et al. (2001). „Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.”. J. Clin. Endocrinol. Metab. 86 (5): 2161–9. DOI:10.1210/jc.86.5.2161. PMID 11344221. 
  • Talme T, Ivanoff J, Hägglund M, et al. (2001). „Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.”. Clin. Exp. Immunol. 125 (1): 71–9. DOI:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428. 
  • Klisovic DD, O'Dorisio MS, Katz SE, et al. (2001). „Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study.”. Invest. Ophthalmol. Vis. Sci. 42 (10): 2193–201. PMID 11527930. 

Spoljašnje veze

  • „Somatostatin Receptors: sst2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  • MeSH somatostatin+receptor+2
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Neuropeptidni receptori
Hormonski receptori
Drugi
Opioidni receptori
Drugi neuropeptidni receptori
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)