Neuromedinski U receptor 1

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Neuromedinski U receptor 1‎‎
Identifikatori
SimboliNMUR1; FM-3; FM3; GPC-R; GPR66; NMU1R
Vanjski IDOMIM: 604153 MGI: 1341898 HomoloGene: 68501 IUPHAR: NMU1 GeneCards: NMUR1 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• aktivnost neuromedinskog U receptora
• receptorska aktivnost
Celularna komponenta • membranska frakcija
• integralno sa ćelijskom membranom
• membrana
Biološki proces • transport jona kalcijuma
• hloridni transport
• kontrakcije glatkih mišića
• prenos signala
• aktivacija fosfolipaze C
• neuropeptidni signalni put
• transmisija nervnog impulsa
• kalcijum-posredovana signalizacija
• sekretorni put
• inozitol fosfat-posredovana signalizacija
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez1031614767
EnsemblENSG00000171596ENSMUSG00000026237
UniProtQ9HB89Q0VB23
RefSeq (mRNA)NM_006056NM_010341
RefSeq (protein)NP_006047NP_034471
Lokacija (UCSC)Chr 2:
232.1 - 232.1 Mb		Chr 1:
88.22 - 88.22 Mb
PubMed pretraga[1][2]

Neuromedinski U receptor 1 je protein koji je kod ljudi kodiran NMUR1 genom.[1][2]

Vidi još

  • Neuromedinski U receptor

Literatura

  1. ↑ Tan CP, McKee KK, Liu Q, Palyha OC, Feighner SD, Hreniuk DL, Smith RG, Howard AD (Dec 1998). „Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors”. Genomics 52 (2): 223–9. DOI:10.1006/geno.1998.5441. PMID 9782091. 
  2. ↑ „Entrez Gene: NMUR1 neuromedin U receptor 1”. 

Dodatna literatura

  • Fujii R, Hosoya M, Fukusumi S, et al. (2000). „Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3.”. J. Biol. Chem. 275 (28): 21068–74. DOI:10.1074/jbc.M001546200. PMID 10783389. 
  • Szekeres PG, Muir AI, Spinage LD, et al. (2000). „Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3.”. J. Biol. Chem. 275 (27): 20247–50. DOI:10.1074/jbc.C000244200. PMID 10811630. 
  • Raddatz R, Wilson AE, Artymyshyn R, et al. (2000). „Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.”. J. Biol. Chem. 275 (42): 32452–9. DOI:10.1074/jbc.M004613200. PMID 10899166. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Mori K, Miyazato M, Ida T, et al. (2005). „Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.”. EMBO J. 24 (2): 325–35. DOI:10.1038/sj.emboj.7600526. PMC 545815. PMID 15635449. 
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). „Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”. Nature 434 (7034): 724–31. DOI:10.1038/nature03466. PMID 15815621. 

Spoljašnje veze

  • „Neuromedin U Receptors: NMU1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2015-04-02. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Neuropeptidni receptori
Hormonski receptori
Drugi
Opioidni receptori
Drugi neuropeptidni receptori
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)