TAS2R16

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Receptor ukusa tip 2 član 16
Identifikatori
SimboliTAS2R16; T2R16
Vanjski IDOMIM: 604867 MGI: 2681247 HomoloGene: 9660 IUPHAR: GeneCards: TAS2R16 Gene
Ontologija gena
Molekularna funkcija • aktivnost receptora ukusa
Celularna komponenta • integralno sa membranom
Biološki proces • signalni put G-protein spregnutog receptora
• hemosensorno ponašanje
• detekcija hemijskog stimulusa koji učestvuje u senzornoj percepciji ukusa
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez50833387347
EnsemblENSG00000128519ENSMUSG00000043865
UniProtQ9NYV7P59529
RefSeq (mRNA)NM_016945.2NM_207022.1
RefSeq (protein)NP_058641.1NP_996905.1
Lokacija (UCSC)Chr 7:
122.63 - 122.64 Mb		Chr 6:
23.92 - 23.92 Mb
PubMed pretraga[1][2]

Receptor ukusa tip 2 član 16 je protein koji je kod ljudi kodiran TAS2R16 genom. [1][2]

Varijante ovog gena su povezane sa povećanim rizikom od alkoholne zavisnosti.[3]

TAS2R16 gen je lociran na dugačkoj (q) ruci hromozoma 7 u poziciji 31.1 - 31.3, od baznog para 122.228.764 do baznog para 122.229.639.

Reference

  1. ↑ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat Genet 32 (3): 397–401. DOI:10.1038/ng1014. PMID 12379855. 
  2. ↑ Drewnowski A (2001). „The science and complexity of bitter taste”. Nutr Rev 59 (6): 163–9. DOI:10.1111/j.1753-4887.2001.tb07007.x. PMID 11444592. 
  3. ↑ Hinrichs AL, Wang JC, Bufe B, et al. (2006). „Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence”. Am. J. Hum. Genet. 78 (1): 103–11. DOI:10.1086/499253. PMC 1380207. PMID 16385453. 

Literatura

  • Kinnamon SC (2000). „A plethora of taste receptors.”. Neuron 25 (3): 507–10. DOI:10.1016/S0896-6273(00)81054-5. PMID 10774719. 
  • Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction.”. J. Biol. Chem. 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554. 
  • Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste.”. Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982. 
  • Adler E, Hoon MA, Mueller KL, et al. (2000). „A novel family of mammalian taste receptors.”. Cell 100 (6): 693–702. DOI:10.1016/S0092-8674(00)80705-9. PMID 10761934. 
  • Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). „T2Rs function as bitter taste receptors.”. Cell 100 (6): 703–11. DOI:10.1016/S0092-8674(00)80706-0. PMID 10761935. 
  • Firestein S (2000). „The good taste of genomics.”. Nature 404 (6778): 552–3. DOI:10.1038/35007167. PMID 10766221. 
  • Matsunami H, Montmayeur JP, Buck LB (2000). „A family of candidate taste receptors in human and mouse.”. Nature 404 (6778): 601–4. DOI:10.1038/35007072. PMID 10766242. 
  • Bufe B, Hofmann T, Krautwurst D, et al. (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.”. Nat. Genet. 32 (3): 397–401. DOI:10.1038/ng1014. PMID 12379855. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.”. Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7.”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes.”. Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549. 
  • Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.”. Genetics 170 (1): 313–26. DOI:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053. 
  • Mueller KL, Hoon MA, Erlenbach I, et al. (2005). „The receptors and coding logic for bitter taste.”. Nature 434 (7030): 225–9. DOI:10.1038/nature03352. PMID 15759003. 
  • Hinrichs AL, Wang JC, Bufe B, et al. (2006). „Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.”. Am. J. Hum. Genet. 78 (1): 103–11. DOI:10.1086/499253. PMC 1380207. PMID 16385453. 
  • Behrens M, Bartelt J, Reichling C, et al. (2006). „Members of RTP and REEP gene families influence functional bitter taste receptor expression.”. J. Biol. Chem. 281 (29): 20650–9. DOI:10.1074/jbc.M513637200. PMID 16720576. 

Spoljašnje veze

  • GeneCard for TAS2R16
  • MeSH TAS2R16+protein,+human

Vidi još

  • p
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)