Cisteinil leukotrienski receptor 2

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Cisteinil leukotrienski receptor 2
Identifikatori
SimboliCYSLTR2; CYSLT2; CYSLT2R; HG57; HPN321; KPG_011; hGPCR21
Vanjski IDOMIM: 605666 MGI: 1917336 HomoloGene: 10688 IUPHAR: CysLT2 GeneCards: CYSLTR2 Gene
Ontologija gena
Molekularna funkcija • aktivnost prenosa signala
• receptorska aktivnost
• aktivnost leukotrienskog receptora
Celularna komponenta • membranska frakcija
• ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • transport kalcijumskih jona
• hemotaksa
• odbrambeni respons
• inflamatorni respons
• povišenje koncentracije citozolinih kalcijumovih jona
• razmena respiratornih gasova
• pozitivna regulacija vazokonstrikcije
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez5710570086
EnsemblENSG00000152207ENSMUSG00000033470
UniProtQ9NS75Q920A1
RefSeq (mRNA)NM_020377.2NM_001162412.1
RefSeq (protein)NP_065110.1NP_001155884.1
Lokacija (UCSC)Chr 13:
49.28 - 49.28 Mb		Chr 14:
73.43 - 73.45 Mb
PubMed pretraga[1][2]

Cisteinil leukotrienski receptor 2 je protein koji je kod ljudi kodiran CYSLTR2 genom.[1][2][3]

Cisteinil leukotrieni LTC4, LTD4, i LTE4 sz važni posrednici ljudske bronhijalne astme. Farmakološka ispitivanja su utvrdila da cisteinil leukotrieni aktiviraju najmanje 2 receptora, protein kodiran ovim genom i CYSLTR1. Ovaj receptor je član superfamilije G protein spregnutih receptora. On je deo endokrinnih i kardiovaskularnih sistema.[3]

Reference

  1. ↑ Takasaki J, Kamohara M, Matsumoto M, Saito T, Sugimoto T, Ohishi T, Ishii H, Ota T, Nishikawa T, Kawai Y, Masuho Y, Isogai T, Suzuki Y, Sugano S, Furuichi K (Aug 2000). „The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor”. Biochem Biophys Res Commun 274 (2): 316–22. DOI:10.1006/bbrc.2000.3140. PMID 10913337. 
  2. ↑ Van Keer C, Kersters K, De Ley J (Sep 1976). „L-Sorbose metabolism in Agrobacterium tumefaciens”. Antonie Van Leeuwenhoek 42 (1–2): 13–24. DOI:10.1007/BF00399445. PMID 1085123. 
  3. ↑ 3,0 3,1 „Entrez Gene: CYSLTR2 cysteinyl leukotriene receptor 2”. 

Literatura

  • Nothacker HP, Wang Z, Zhu Y, et al. (2001). „Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist”. Mol. Pharmacol. 58 (6): 1601–8. PMID 11093801. 
  • Mita H, Hasegawa M, Saito H, Akiyama K (2002). „Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils”. Clin. Exp. Allergy 31 (11): 1714–23. DOI:10.1046/j.1365-2222.2001.01184.x. PMID 11696047. 
  • Takeda S, Kadowaki S, Haga T, et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence”. FEBS Lett. 520 (1–3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
  • Shirasaki H, Kanaizumi E, Watanabe K, et al. (2003). „Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa”. Clin. Exp. Allergy 32 (7): 1007–12. DOI:10.1046/j.1365-2222.2002.01425.x. PMID 12100046. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Sjöström M, Johansson AS, Schröder O, et al. (2004). „Dominant expression of the CysLT2 receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells”. Arterioscler. Thromb. Vasc. Biol. 23 (8): e37–41. DOI:10.1161/01.ATV.0000082689.46538.DF. PMID 12816881. 
  • Mellor EA, Frank N, Soler D, et al. (2003). „Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R”. Proc. Natl. Acad. Sci. U.S.A. 100 (20): 11589–93. DOI:10.1073/pnas.2034927100. PMC 208802. PMID 13679572. 
  • Thompson MD, Storm van's Gravesande K, Galczenski H, et al. (2004). „A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha”. Pharmacogenetics 13 (10): 641–9. DOI:10.1097/01.fpc.0000054127.14659.42. PMID 14515063. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). „The DNA sequence and analysis of human chromosome 13”. Nature 428 (6982): 522–8. DOI:10.1038/nature02379. PMC 2665288. PMID 15057823. 
  • Fukai H, Ogasawara Y, Migita O, et al. (2005). „Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma”. Pharmacogenetics 14 (10): 683–90. DOI:10.1097/00008571-200410000-00006. PMID 15454733. 
  • Pillai SG, Cousens DJ, Barnes AA, et al. (2005). „A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma”. Pharmacogenetics 14 (9): 627–33. DOI:10.1097/00008571-200409000-00007. PMID 15475736. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Hui Y, Cheng Y, Smalera I, et al. (2005). „Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure”. Circulation 110 (21): 3360–6. DOI:10.1161/01.CIR.0000147775.50954.AA. PMID 15545522. 
  • Corrigan C, Mallett K, Ying S, et al. (2005). „Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis”. J. Allergy Clin. Immunol. 115 (2): 316–22. DOI:10.1016/j.jaci.2004.10.051. PMID 15696087. 
  • Uzonyi B, Lötzer K, Jahn S, et al. (2006). „Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells”. Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6326–31. DOI:10.1073/pnas.0601223103. PMC 1458877. PMID 16606835. 
  • Woszczek G, Chen LY, Nagineni S, et al. (2007). „IFN-gamma induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes”. J. Immunol. 178 (8): 5262–70. PMID 17404310. 
  • Klotsman M, York TP, Pillai SG, et al. (2007). „Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast”. Pharmacogenet. Genomics 17 (3): 189–96. DOI:10.1097/FPC.0b013e3280120043. PMID 17460547. 

Vidi još

Spoljašnje veze

  • „Leukotriene Receptors: CysLT2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)