Melanokortinski 3 receptor
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| Melanokortin 3 receptor | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | MC3R; MC3 | ||||||||||
| Vanjski ID | OMIM: 155540 MGI: 96929 HomoloGene: 7412 IUPHAR: MC3 GeneCards: MC3R Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4159 | 17201 | |||||||||
| Ensembl | ENSG00000124089 | ENSMUSG00000038537 | |||||||||
| UniProt | P41968 | Q3ZAT4 | |||||||||
| RefSeq (mRNA) | NM_019888 | NM_008561 | |||||||||
| RefSeq (protein) | NP_063941 | NP_032587 | |||||||||
| Lokacija (UCSC) | Chr 20: 54.26 - 54.26 Mb | Chr 2: 171.94 - 171.94 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Melanokortin receptor 3 je protein koji je kod ljudi kodiran MC3R genom.[1][2]
MC3 je G-protein spregnuti receptor za melanocit-stimulišući hormon i adrenokortikotropski hormon koji je izražen u tkivima izvan adrenalnog korteksa i melanocita. MC3R gen je lociran u istom regionu kao i locus za benignu neonatalnu epilepsiju. Miševi koji su deficitarni u ovom genu imaju povišenu masu masnog tkiva uprkos umanjenog unosa hrane, što sugestira ulogu ovog genskog produkta u regulaciji energijske homeostaze.[2]
Vidi još
- Melanokortin receptor
Literatura
Dodatna literatura
- Magenis RE, Smith L, Nadeau JH, et al. (1994). „Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human.”. Mamm. Genome 5 (8): 503–8. DOI:10.1007/BF00369320. PMID 7949735.
- Konda Y, Gantz I, DelValle J, et al. (1994). „Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor.”. J. Biol. Chem. 269 (18): 13162–6. PMID 8175743.
- Gantz I, Tashiro T, Barcroft C, et al. (1994). „Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.”. Genomics 18 (1): 166–7. DOI:10.1006/geno.1993.1448. PMID 8276410.
- Yang YK, Ollmann MM, Wilson BD, et al. (1997). „Effects of recombinant agouti-signaling protein on melanocortin action.”. Mol. Endocrinol. 11 (3): 274–80. DOI:10.1210/me.11.3.274. PMID 9058374.
- Tota MR, Smith TS, Mao C, et al. (1999). „Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors.”. Biochemistry 38 (3): 897–904. DOI:10.1021/bi9815602. PMID 9893984.
- McNulty JC, Thompson DA, Bolin KA, et al. (2002). „High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein.”. Biochemistry 40 (51): 15520–7. DOI:10.1021/bi0117192. PMID 11747427.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052.
- Lee YS, Poh LK, Loke KY (2002). „A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity.”. J. Clin. Endocrinol. Metab. 87 (3): 1423–6. DOI:10.1210/jc.87.3.1423. PMID 11889220.
- Qian S, Chen H, Weingarth D, et al. (2002). „Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice.”. Mol. Cell. Biol. 22 (14): 5027–35. DOI:10.1128/MCB.22.14.5027-5035.2002. PMC 139785. PMID 12077332.
- Boucher N, Lanouette CM, Larose M, et al. (2003). „A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence.”. Mol. Med. 8 (3): 158–65. PMC 2039979. PMID 12142547.
- Wong J, Love DR, Kyle C, et al. (2002). „Melanocortin-3 receptor gene variants in a Maori kindred with obesity and early onset type 2 diabetes.”. Diabetes Res. Clin. Pract. 58 (1): 61–71. DOI:10.1016/S0168-8227(02)00126-2. PMID 12161058.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Rached M, Buronfosse A, Begeot M, Penhoat A (2004). „Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity.”. Biochim. Biophys. Acta 1689 (3): 229–34. DOI:10.1016/j.bbadis.2004.03.009. PMID 15276649.
- Tao YX, Segaloff DL (2004). „Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.”. J. Clin. Endocrinol. Metab. 89 (8): 3936–42. DOI:10.1210/jc.2004-0367. PMID 15292330.
- Lapinsh M, Veiksina S, Uhlén S, et al. (2005). „Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.”. Mol. Pharmacol. 67 (1): 50–9. DOI:10.1124/mol.104.002857. PMID 15470082.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mandrika I, Petrovska R, Wikberg J (2005). „Melanocortin receptors form constitutive homo- and heterodimers.”. Biochem. Biophys. Res. Commun. 326 (2): 349–54. DOI:10.1016/j.bbrc.2004.11.036. PMID 15582585.
- de Krom M, de Rijke CE, Hendriks J, et al. (2006). „Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients.”. Psychiatr. Genet. 15 (4): 237. DOI:10.1097/00041444-200512000-00003. PMID 16314751.
- Chen M, Aprahamian CJ, Celik A, et al. (2006). „Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction.”. Biochemistry 45 (4): 1128–37. DOI:10.1021/bi0521792. PMID 16430209.
- „Melanocortin Receptors: MC3”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-02-06.
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Drugi | Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2) |
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glutamat / feromon
Drugi |
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Frizzled / Zaglađeni
Uvojiti | |
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Zaglađeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
