AGTR2

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Angiotenzinski II receptor tip 2‎‎
Identifikatori
SimboliAGTR2; AT2; ATGR2; MRX88
Vanjski IDOMIM: 300034 MGI: 87966 HomoloGene: 20172 IUPHAR: AT2 GeneCards: AGTR2 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• aktivnost inhibitora proteinske kinaze
• receptorska aktivnost
• aktivnost angiotenzin tip II receptora
• aktivnost bradikininskog receptora
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • angiotenzinom posredovana vazodilatacija tokom regulacije krvnog pritiska
• moždani renin-angiotenzin sistem
• apoptoza
• signalni put G-protein spregnutog receptora
• ponašanje
• regulacija krvnog pritiska
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez18611609
EnsemblENSG00000180772ENSMUSG00000068122
UniProtP50052Q3US12
RefSeq (mRNA)NM_000686NM_007429
RefSeq (protein)NP_000677NP_031455
Lokacija (UCSC)Chr X:
115.22 - 115.22 Mb		Chr X:
20.64 - 20.65 Mb
PubMed pretraga[1][2]

Angiotenzinski II receptor tip 2, (AT2 receptor) je protein koji je kod ljudi kodiran AGTR2 genom.[1]

Funkcija

Angiotenzin II je potentan vazokonstrikcioni hormon i primarni regulator aldosteronske sekrecije. On je važan efektor kontrole krvnog pritiska i zapremine kardiovaskularnog sistema. On deluje kroz najmanje dva tipa receptora: AT1 i AT2. AGTR2 pripada familiji 1 G protein-spregnutih receptora. On je integralni membranski protein. On učestvuje u funkcijama centralnog nervnog i kardiovaskularnog sistema koje su posredovane renin-angiotenzinskim sistemom. Ovaj receptor posreduje programiranu ćelijsku smrt (apoptozu). Kod odraslih osoba, on je visoko izražen u miometrijumu sa niskim nivoima u nadbubrežnoj žlezdi i jajovodima. On je visoko izražen u fetalnim bubrezima i interstinalnom sistemu. Humani AGTR2 gen se sastoji od sastoji od tri eksona na rasponu od najmanje 5 kb.[1]

Stimulacija AT2 receptora selektivnim agonistom CGP 42112A povećava proizvodnju azot-monoksida sluzokože.[2]

Interakcije

Za angiotenzinski II receptor tip 2 je pokazano da interaguje sa MTUS1.[3]

Vidi još

Reference

  1. ↑ 1,0 1,1 „Entrez Gene: AGTR2 angiotensin II receptor, type 2”. 
  2. ↑ Ewert S, Laesser M, Johansson B, Holm M, Aneman A, Fandriks L (March 2003). „The angiotensin II receptor type 2 agonist CGP 42112A stimulates NO production in the porcine jejunal mucosa”. BMC Pharmacol. 3: 2. DOI:10.1186/1471-2210-3-2. PMC 153509. PMID 12689346. 
  3. ↑ Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (July 2004). „Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP”. J. Biol. Chem. 279 (28): 28989–97. DOI:10.1074/jbc.M403880200. PMID 15123706. 

Literatura

  • de Gasparo M, Catt KJ, Inagami T, "et al." (2000). „International union of pharmacology. XXIII. The angiotensin II receptors”. Parmacol Rev. 52 (3): 415–472. PMID 10977869. 
  • D'Amore A, Black MJ, Thomas WG (2005). „The angiotensin II type 2 receptor causes constituative growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy”. Hypertension 46 (6): 1347–1354. DOI:10.1161/01.HYP.0000193504.51489.cf. PMID 16286564. 
  • Regitz-Zagrosek V, Neuss M, Warnecke C, et al. (1997). „Subtype 2 and atypical angiotensin receptors in the human heart.”. Basic Res. Cardiol. 91 Suppl 2: 73–7. PMID 8957548. 
  • Berry C, Touyz R, Dominiczak AF, et al. (2002). „Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.”. Am. J. Physiol. Heart Circ. Physiol. 281 (6): H2337–65. PMID 11709400. 
  • Takayanagi R, Ohnaka K, Sakai Y, et al. (1992). „Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.”. Biochem. Biophys. Res. Commun. 183 (2): 910–6. DOI:10.1016/0006-291X(92)90570-B. PMID 1550596. 
  • Hein L, Barsh GS, Pratt RE, et al. (1995). „Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice.”. Nature 377 (6551): 744–7. DOI:10.1038/377744a0. PMID 7477266. 
  • Ichiki T, Labosky PA, Shiota C, et al. (1995). „Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.”. Nature 377 (6551): 748–50. DOI:10.1038/377748a0. PMID 7477267. 
  • Lazard D, Briend-Sutren MM, Villageois P, et al. (1995). „Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues.”. Recept. Channels 2 (4): 271–80. PMID 7719706. 
  • Martin MM, Elton TS (1995). „The sequence and genomic organization of the human type 2 angiotensin II receptor.”. Biochem. Biophys. Res. Commun. 209 (2): 554–62. DOI:10.1006/bbrc.1995.1537. PMID 7733925. 
  • Chassagne C, Beatty BG, Meloche S (1995). „Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization.”. Genomics 25 (2): 601–3. DOI:10.1016/0888-7543(95)80072-T. PMID 7790004. 
  • Koike G, Horiuchi M, Yamada T, et al. (1994). „Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.”. Biochem. Biophys. Res. Commun. 203 (3): 1842–50. DOI:10.1006/bbrc.1994.2402. PMID 7945336. 
  • Martin MM, Su B, Elton TS (1995). „Molecular cloning of the human angiotensin II type 2 receptor cDNA.”. Biochem. Biophys. Res. Commun. 205 (1): 645–51. DOI:10.1006/bbrc.1994.2714. PMID 7999093. 
  • Tsuzuki S, Ichiki T, Nakakubo H, et al. (1994). „Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor.”. Biochem. Biophys. Res. Commun. 200 (3): 1449–54. DOI:10.1006/bbrc.1994.1613. PMID 8185599. 
  • Servant G, Boulay G, Bossé R, et al. (1993). „Photoaffinity labeling of subtype 2 angiotensin receptor of human myometrium.”. Mol. Pharmacol. 43 (5): 677–83. PMID 8502225. 
  • Yamada T, Horiuchi M, Dzau VJ (1996). „Angiotensin II type 2 receptor mediates programmed cell death.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 156–60. DOI:10.1073/pnas.93.1.156. PMC 40197. PMID 8552595. 
  • Zhang J, Pratt RE (1996). „The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus.”. J. Biol. Chem. 271 (25): 15026–33. DOI:10.1074/jbc.271.25.15026. PMID 8663053. 
  • Katsuya T, Horiuchi M, Minami S, et al. (1997). „Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome.”. Mol. Cell. Endocrinol. 127 (2): 221–8. DOI:10.1016/S0303-7207(97)04011-2. PMID 9099917. 
  • Akishita M, Ito M, Lehtonen JY, et al. (1999). „Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth.”. J. Clin. Invest. 103 (1): 63–71. DOI:10.1172/JCI5182. PMC 407869. PMID 9884335. 
  • Lehtonen JY, Daviet L, Nahmias C, et al. (1999). „Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.”. Mol. Endocrinol. 13 (7): 1051–60. DOI:10.1210/me.13.7.1051. PMID 10406457. 
  • Knowle D, Ahmed S, Pulakat L (2000). „Identification of an interaction between the angiotensin II receptor sub-type AT2 and the ErbB3 receptor, a member of the epidermal growth factor receptor family.”. Regul. Pept. 87 (1-3): 73–82. DOI:10.1016/S0167-0115(99)00111-1. PMID 10710290. 
  • Hansen JL, Servant G, Baranski TJ, et al. (2000). „Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation.”. Circ. Res. 87 (9): 753–9. PMID 11055978. 

Spoljašnje veze

  • „Angiotensin Receptors: AT2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-06-16. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)