AGTR1

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Angiotenzinski II receptor, tip 1
Identifikatori
SimboliAGTR1; AG2S; AGTR1A; AGTR1B; AT1; AT1B; AT2R1; AT2R1A; AT2R1B; HAT1R
Vanjski IDOMIM: 106165 MGI: 87964 HomoloGene: 3556 IUPHAR: AT1 GeneCards: AGTR1 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• receptorska aktivnost
• aktivnost angiotenzin tip II receptora
• aktivnost bradikininskog receptora
• aktivnost C-X-C hemokinskog receptora
Celularna komponenta • ćelijska membrana
• integralno sa ćelijskom membranom
• membrana
• integralno sa membranom
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• G-protein signalizacija, spregnuta sa IP3 sekundarnim glasnikom (aktivacija fosfolipaze C)
• elevacija koncentracije citosolnih jona kalcijuma
• sekrecija fluida
• cirkulacija
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez18511607
EnsemblENSG00000144891ENSMUSG00000049115
UniProtP30556Q5SVY5
RefSeq (mRNA)NM_000685NM_177322
RefSeq (protein)NP_000676NP_796296
Lokacija (UCSC)Chr 3:
149.9 - 149.94 Mb		Chr 13:
30.34 - 30.39 Mb
PubMed pretraga[1][2]

AGTR1 (Angiotenzinski II receptor, tip 1, AT1 receptor) je angiotenzinski receptor. On ima simpatomimetičko dejstvo i reguliše sekreciju aldosterona. On je značajan efektor kontrole krvnog pritiska i zapremine u kardiovaskularnom sistemu. Antagonisti angiotenzin II receptora su lekovi za hipertenziju, dijabetesnu nefropatiju i srčanu insuficijenciju. AGTR1 je najbolje istraženi angiotenzinski receptor.

Mehanizam

Angiotenzinski receptori se aktiviraju vazokonstriktivnim peptidom angiotenzin II. Aktivirani receptor se spreže sa Gq/11, aktivira fosfolipazu C i povišava koncentraciju citosolnog Ca2+, čime se zatim inicira ćelijski respons kao što je stimulacija proteinske kinaze C. Aktivirani receptor takođe inhibira adenilat ciklazu i razne tirozinske kinaze.[1]

Reference

  1. ↑ Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). „Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology”. Clin. Sci. 112 (8): 417–28. DOI:10.1042/CS20060342. PMID 17346243. 

Literatura

  • Matsusaka T, Ichikawa I (1997). „Biological functions of angiotensin and its receptors.”. Annu. Rev. Physiol. 59: 395–412. DOI:10.1146/annurev.physiol.59.1.395. PMID 9074770. 
  • Allen AM, Moeller I, Jenkins TA, et al. (1998). „Angiotensin receptors in the nervous system.”. Brain Res. Bull. 47 (1): 17–28. DOI:10.1016/S0361-9230(98)00039-2. PMID 9766385. 
  • Berry C, Touyz R, Dominiczak AF, et al. (2002). „Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.”. Am. J. Physiol. Heart Circ. Physiol. 281 (6): H2337–65. PMID 11709400. 
  • Arima S, Ito S (2001). „New insights into actions of the renin-angiotensin system in the kidney: concentrating on the Ang II receptors and the newly described Ang-(1-7) and its receptor.”. Semin. Nephrol. 21 (6): 535–43. DOI:10.1053/snep.2001.26792. PMID 11709801. 
  • Stowasser M, Gunasekera TG, Gordon RD (2002). „Familial varieties of primary aldosteronism.”. Clin. Exp. Pharmacol. Physiol. 28 (12): 1087–90. DOI:10.1046/j.1440-1681.2001.03574.x. PMID 11903322. 
  • Padmanabhan N, Padmanabhan S, Connell JM (2002). „Genetic basis of cardiovascular disease--the renin-angiotensin-aldosterone system as a paradigm.”. Journal of the renin-angiotensin-aldosterone system : JRAAS 1 (4): 316–24. DOI:10.3317/jraas.2000.060. PMID 11967817. 
  • Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). „Molecular pharmacology and modeling of vasopressin receptors.”. Prog. Brain Res. 139: 179–96. DOI:10.1016/S0079-6123(02)39016-2. PMID 12436935. 
  • Elton TS, Martin MM (2003). „Alternative splicing: a novel mechanism to fine-tune the expression and function of the human AT1 receptor.”. Trends Endocrinol. Metab. 14 (2): 66–71. DOI:10.1016/S1043-2760(02)00038-3. PMID 12591176. 
  • Saavedra JM, Benicky J, Zhou J (2007). „Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT( 1 ) Receptor Antagonists in the Brain.”. Cell. Mol. Neurobiol. 26 (7-8): 1099–111. DOI:10.1007/s10571-006-9009-0. PMID 16636899. 
  • Oliveira L, Costa-Neto CM, Nakaie CR, et al. (2007). „The angiotensin II AT1 receptor structure-activity correlations in the light of rhodopsin structure.”. Physiol. Rev. 87 (2): 565–92. DOI:10.1152/physrev.00040.2005. PMID 17429042. 
  • Ariza AC, Bobadilla NA, Halhali A (2007). „[Endothelin 1 and angiotensin II in preeeclampsia]”. Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300. 
  • Xia Y, Zhou CC, Ramin SM, Kellems RE (2007). „Angiotensin receptors, autoimmunity, and preeclampsia.”. J. Immunol. 179 (6): 3391–5. PMID 17785770. 
  • Mauzy CA, Hwang O, Egloff AM, et al. (1992). „Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor.”. Biochem. Biophys. Res. Commun. 186 (1): 277–84. DOI:10.1016/S0006-291X(05)80804-6. PMID 1378723. 
  • Curnow KM, Pascoe L, White PC (1992). „Genetic analysis of the human type-1 angiotensin II receptor.”. Mol. Endocrinol. 6 (7): 1113–8. DOI:10.1210/me.6.7.1113. PMID 1508224. 
  • Furuta H, Guo DF, Inagami T (1992). „Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor.”. Biochem. Biophys. Res. Commun. 183 (1): 8–13. DOI:10.1016/0006-291X(92)91600-U. PMID 1543512. 
  • Takayanagi R, Ohnaka K, Sakai Y, et al. (1992). „Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.”. Biochem. Biophys. Res. Commun. 183 (2): 910–6. DOI:10.1016/0006-291X(92)90570-B. PMID 1550596. 
  • Bergsma DJ, Ellis C, Kumar C, et al. (1992). „Cloning and characterization of a human angiotensin II type 1 receptor.”. Biochem. Biophys. Res. Commun. 183 (3): 989–95. DOI:10.1016/S0006-291X(05)80288-8. PMID 1567413. 
  • Gemmill RM, Drabkin HA (1992). „Report of the Second International Workshop on Human Chromosome 3 mapping.”. Cytogenet. Cell Genet. 57 (4): 162–6. PMID 1683828. 
  • Curnow KM, Pascoe L, Davies E, et al. (1996). „Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms.”. Mol. Endocrinol. 9 (9): 1250–62. DOI:10.1210/me.9.9.1250. PMID 7491117. 
  • Marrero MB, Schieffer B, Paxton WG, et al. (1995). „Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.”. Nature 375 (6528): 247–50. DOI:10.1038/375247a0. PMID 7746328. 

Spoljašnje veze

  • „Angiotensin Receptors: AT1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-02-28. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)