GPR77

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G protein-spregnuti receptor 77
Identifikatori
SimboliGPR77; C5L2; GPF77
Vanjski IDOMIM: 609949 MGI: 2442013 HomoloGene: 49549 IUPHAR: C5L2 GeneCards: GPR77 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu sličnog receptora
• receptorska aktivnost
• aktivnost C5a anafilatoksičnog receptora
Celularna komponenta • ćelijska_komponenta
• integralno sa ćelijskom membranom
• membrana
Biološki proces • hemotaksa
• prenos signal
• signalni put G-protein spregnutog receptora
• biološki_proces
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez27202319430
EnsemblENSG00000134830ENSMUSG00000074361
UniProtQ9P296n/a
RefSeq (mRNA)NM_018485NM_176912
RefSeq (protein)NP_060955NP_795886
Lokacija (UCSC)Chr 19:
52.54 - 52.54 Mb		Chr 7:
15.4 - 15.4 Mb
PubMed pretraga[1][2]

GPR77, G protein-spregnuti receptor 77, ili C5a anafilatoksinski hemotaksni receptor C5L2, je protein koji je kod čoveka kodiran GPR77 genom.[1][2]

Anafilatoksini C3a, C4a, i C5a su katjonski fragmenti formirani tokom kaskade komplementa koja učestvuje u odbrani domaćina. U slučaju neodgovarajuće aktivacije komplementa, anafilatoksini mogu da učestvuju u autoimunosti i sepsi. C5L2 je izražen zajedno sa C5a receptorom (C5R1), na polimorfonuklearnim neutrofilima i može da modulira C5AR aktivnost.[3][2]

Literatura

  1. ↑ Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). „Identification of four novel human G protein-coupled receptors expressed in the brain”. Brain Res Mol Brain Res 86 (1-2): 13–22. DOI:10.1016/S0169-328X(00)00242-4. PMID 11165367. 
  2. ↑ 2,0 2,1 „Entrez Gene: GPR77 G protein-coupled receptor 77”. 
  3. ↑ Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 

Dodatna literatura

  • Ohno M, Hirata T, Enomoto M, et al. (2000). „A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells.”. Mol. Immunol. 37 (8): 407–12. DOI:10.1016/S0161-5890(00)00067-5. PMID 11090875. 
  • Cain SA, Monk PN (2002). „The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).”. J. Biol. Chem. 277 (9): 7165–9. DOI:10.1074/jbc.C100714200. PMID 11773063. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Kalant D, Cain SA, Maslowska M, et al. (2003). „The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein.”. J. Biol. Chem. 278 (13): 11123–9. DOI:10.1074/jbc.M206169200. PMID 12540846. 
  • Otto M, Hawlisch H, Monk PN, et al. (2004). „C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism.”. J. Biol. Chem. 279 (1): 142–51. DOI:10.1074/jbc.M310078200. PMID 14570896. 
  • Huber-Lang M, Sarma JV, Rittirsch D, et al. (2005). „Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans.”. J. Immunol. 174 (2): 1104–10. PMID 15634936. 
  • Kalant D, MacLaren R, Cui W, et al. (2005). „C5L2 is a functional receptor for acylation-stimulating protein.”. J. Biol. Chem. 280 (25): 23936–44. DOI:10.1074/jbc.M406921200. PMID 15833747. 
  • Johswich K, Martin M, Thalmann J, et al. (2007). „Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines.”. J. Biol. Chem. 281 (51): 39088–95. DOI:10.1074/jbc.M609734200. PMID 17068344. 
  • Scola AM, Higginbottom A, Partridge LJ, et al. (2007). „The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding.”. J. Biol. Chem. 282 (6): 3664–71. DOI:10.1074/jbc.M609178200. PMC 2873560. PMID 17158873. 

Spoljašnje veze

  • „Anaphylatoxin Receptors: C5L2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2012-03-05. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)