EP4 receptor

edit
Prostaglandinski E receptor 4
Identifikatori
SimboliPTGER4; EP4; EP4R
Vanjski IDOMIM: 601586 MGI: 104311 HomoloGene: 20261 IUPHAR: EP4 GeneCards: PTGER4 Gene
Ontologija gena
Molekularna funkcija • aktivnost prostaglandinskog E receptora
• proteinskog vezivanje
Celularna komponenta • ćelijska membrana
• integralno sa membranom
Biološki proces • imunski respons
• signalni put adenilat ciklazom modulisanog G-protein spregnutog receptora
• JNK kaskada
Ortolozi
VrstaČovekMiš
Entrez573419219
EnsemblENSG00000171522ENSMUSG00000039942
UniProtP35408P32240
RefSeq (mRNA)NM_000958.2NM_001136079.1
RefSeq (protein)NP_000949.1NP_001129551.1
Lokacija (UCSC)Chr 5:
40.68 - 40.69 Mb		Chr 15:
5.16 - 5.19 Mb
PubMed pretraga[1][2]

Prostaglandinski E receptor 4 (EP4) je prostaglandinski receptor kodiran PTGER4 genom kod ljudi.

Protein kodiran ovim genom je član familije G protein spregnutih receptora. Ovaj protein je jedan od četiri receptora identifikovana za prostaglandin E2 (PGE2). On može da aktivira signalizaciju T-ćelijskog faktora. Pokazano je posreduje PGE2 indukovano izražavanje EGR1 faktora, reguliše nivo i stabilnost cikloksigenaze-2 iRNK, i dovodi do fosforilacije glikogen sintaze kinaze-3. Studije na nokaut miševima sugeriraju da ovaj receptor učestvuje u neonatalnoj adaptaciji circulatornog sistema, osteoporozi, kao i inicijaciji kožnog imunskog responsa.[1]

Reference

  1. ↑ „Entrez Gene: PTGER4 prostaglandin E receptor 4 (subtype EP4)”. 

Literatura

  • Duncan AM, Anderson LL, Funk CD i dr.. (1995). „Chromosomal localization of the human prostanoid receptor gene family”. Genomics 25 (3): 740–2. DOI:10.1016/0888-7543(95)80022-E. PMID 7759114. 
  • Regan JW, Bailey TJ, Pepperl DJ i dr.. (1994). „Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype”. Mol. Pharmacol. 46 (2): 213–20. PMID 8078484. 
  • Bastien L, Sawyer N, Grygorczyk R i dr.. (1994). „Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype”. J. Biol. Chem. 269 (16): 11873–7. PMID 8163486. 
  • An S, Yang J, Xia M, Goetzl EJ (1994). „Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2”. Biochem. Biophys. Res. Commun. 197 (1): 263–70. DOI:10.1006/bbrc.1993.2470. PMID 8250933. 
  • Foord SM, Marks B, Stolz M i dr.. (1996). „The structure of the prostaglandin EP4 receptor gene and related pseudogenes”. Genomics 35 (1): 182–8. DOI:10.1006/geno.1996.0337. PMID 8661119. 
  • Fedyk ER, Phipps RP (1996). „Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells”. Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10978–83. DOI:10.1073/pnas.93.20.10978. PMC 38269. PMID 8855294. 
  • Mori K, Tanaka I, Kotani M i dr.. (1996). „Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester”. J. Mol. Med. 74 (6): 333–6. DOI:10.1007/BF00207510. PMID 8862514. 
  • Mukhopadhyay P, Geoghegan TE, Patil RV i dr.. (1997). „Detection of EP2, EP4, and FP receptors in human ciliary epithelial and ciliary muscle cells”. Biochem. Pharmacol. 53 (9): 1249–55. DOI:10.1016/S0006-2952(97)00011-7. PMID 9214685. 
  • Cosme R, Lublin D, Takafuji V i dr.. (2000). „Prostanoids in human colonic mucosa: effects of inflammation on PGE(2) receptor expression”. Hum. Immunol. 61 (7): 684–96. DOI:10.1016/S0198-8859(00)00131-2. PMID 10880739. 
  • Desai S, April H, Nwaneshiudu C, Ashby B (2001). „Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration”. Mol. Pharmacol. 58 (6): 1279–86. PMID 11093764. 
  • Sales KJ, Katz AA, Davis M i dr.. (2001). „Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors”. J. Clin. Endocrinol. Metab. 86 (5): 2243–9. DOI:10.1210/jc.86.5.2243. PMC 2694306. PMID 11344234. 
  • Faour WH, He Y, He QW i dr.. (2001). „Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts”. J. Biol. Chem. 276 (34): 31720–31. DOI:10.1074/jbc.M104036200. PMID 11423555. 
  • Desai S, Ashby B (2001). „Agonist-induced internalization and mitogen-activated protein kinase activation of the human prostaglandin EP4 receptor”. FEBS Lett. 501 (2–3): 156–60. DOI:10.1016/S0014-5793(01)02640-0. PMID 11470276. 
  • Slipetz D, Buchanan S, Mackereth C i dr.. (2001). „Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail”. Biochem. Pharmacol. 62 (8): 997–1012. DOI:10.1016/S0006-2952(01)00742-0. PMID 11597569. 
  • Fujino H, West KA, Regan JW (2002). „Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2”. J. Biol. Chem. 277 (4): 2614–9. DOI:10.1074/jbc.M109440200. PMID 11706038. 
  • Mutoh M, Watanabe K, Kitamura T i dr.. (2002). „Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis”. Cancer Res. 62 (1): 28–32. PMID 11782353. 
  • Kvirkvelia N, Vojnovic I, Warner TD i dr.. (2002). „Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells”. Clin. Exp. Immunol. 127 (2): 263–9. DOI:10.1046/j.1365-2249.2002.01718.x. PMC 1906325. PMID 11876748. 
  • Asano T, Shoda J, Ueda T i dr.. (2002). „Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression”. Clin. Cancer Res. 8 (4): 1157–67. PMID 11948128. 
  • Kyveris A, Maruscak E, Senchyna M (2002). „Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR”. Mol. Vis. 8: 51–8. PMID 11951086. 
  • Scandella E, Men Y, Gillessen S i dr.. (2002). „Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells”. Blood 100 (4): 1354–61. DOI:10.1182/blood-2001-11-0017. PMID 12149218. 

Vidi još

Spoljašnje veze

  • „Prostanoid Receptors: EP4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)