Leukotrienski B4 receptor 2

edit
Leukotrienski B4 receptor 2
Identifikatori
SimboliLTB4R2; BLT2; BLTR2; JULF2; KPG_004; LTB4-R 2; LTB4-R2; NOP9
Vanjski IDOMIM: 605773 MGI: 1888501 HomoloGene: 10519 IUPHAR: BLT2 GeneCards: LTB4R2 Gene
Ontologija gena
Molekularna funkcija • aktivnost leukotrienskog B4 receptora
• aktivnost prenosnika signala
• receptorska aktivnost
• aktivnost leukotrienskog receptora
Celularna komponenta • membranska frakcija
• ćelijska membrana
• integralno sa ćelijskom membranom
• integralno sa membranom
Biološki proces • hemotaksa
• prenos signala
• signalni put G-protein spregnutog receptora
• negativna regulacija adenilat ciklaze
• migracija keratinocita
Ortolozi
VrstaČovekMiš
Entrez5641357260
EnsemblENSG00000213906ENSMUSG00000040432
UniProtQ9NPC1Q9JJL9
RefSeq (mRNA)NM_001164692.2NM_020490.2
RefSeq (protein)NP_001158164.1NP_065236.1
Lokacija (UCSC)Chr 14:
24.77 - 24.78 Mb		Chr 14:
56.38 - 56.38 Mb
PubMed pretraga[1][2]

Leukotrienski B4 receptor 2 je protein koji je kod ljudi kodiran LTB4R2 genom.[1][2][3]

Ovaj receptor ima nizak afinitet za leukotriene. On posreduje hemotaksu granulocita i makrofaga.

Reference

  1. ↑ Wang S, Gustafson E, Pang L, Qiao X, Behan J, Maguire M, Bayne M, Laz T (Jan 2001). „A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization”. J Biol Chem 275 (52): 40686–94. DOI:10.1074/jbc.M004512200. PMID 11006272. 
  2. ↑ Kato K, Yokomizo T, Izumi T, Shimizu T (Sep 2000). „Cell-Specific Transcriptional Regulation of Human Leukotriene B4 Receptor Gene”. J Exp Med 192 (3): 413–20. DOI:10.1084/jem.192.3.413. PMC 2193224. PMID 10934229. 
  3. ↑ „Entrez Gene: LTB4R2 leukotriene B4 receptor 2”. 

Literatura

  • Tager AM, Luster AD (2004). „BLT1 and BLT2: the leukotriene B(4) receptors”. Prostaglandins Leukot. Essent. Fatty Acids 69 (2–3): 123–34. DOI:10.1016/S0952-3278(03)00073-5. PMID 12895595. 
  • Kamohara M, Takasaki J, Matsumoto M, et al. (2000). „Molecular cloning and characterization of another leukotriene B4 receptor”. J. Biol. Chem. 275 (35): 27000–4. DOI:10.1074/jbc.C000382200. PMID 10889186. 
  • Tryselius Y, Nilsson NE, Kotarsky K, et al. (2000). „Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor”. Biochem. Biophys. Res. Commun. 274 (2): 377–82. DOI:10.1006/bbrc.2000.3152. PMID 10913346. 
  • Nilsson NE, Tryselius Y, Owman C (2000). „Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14”. Biochem. Biophys. Res. Commun. 274 (2): 383–8. DOI:10.1006/bbrc.2000.3153. PMID 10913347. 
  • Yokomizo T, Kato K, Terawaki K, et al. (2000). „A Second Leukotriene B4 Receptor, Blt2: A New Therapeutic Target in Inflammation and Immunological Disorders”. J. Exp. Med. 192 (3): 421–32. DOI:10.1084/jem.192.3.421. PMC 2193217. PMID 10934230. 
  • Takeda S, Kadowaki S, Haga T, et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence”. FEBS Lett. 520 (1–3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Hashimoto A, Endo H, Hayashi I, et al. (2003). „Differential expression of leukotriene B4 receptor subtypes (BLT1 and BLT2) in human synovial tissues and synovial fluid leukocytes of patients with rheumatoid arthritis”. J. Rheumatol. 30 (8): 1712–8. PMID 12913925. 
  • Yoo MH, Song H, Woo CH, et al. (2005). „Role of the BLT2, a leukotriene B4 receptor, in Ras transformation”. Oncogene 23 (57): 9259–68. DOI:10.1038/sj.onc.1208151. PMID 15489890. 
  • Qiu H, Johansson AS, Sjöström M, et al. (2006). „Differential induction of BLT receptor expression on human endothelial cells by lipopolysacharide, cytokines, and leukotriene B4”. Proc. Natl. Acad. Sci. U.S.A. 103 (18): 6913–8. DOI:10.1073/pnas.0602208103. PMC 1440767. PMID 16624877. 
  • Lundeen KA, Sun B, Karlsson L, Fourie AM (2006). „Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells”. J. Immunol. 177 (5): 3439–47. PMID 16920986. 

Vidi još

Spoljašnje veze

  • IUPHAR GPCR Database - Leukotriene receptors Arhivirano 2016-03-03 na Wayback Machine-u
  • MeSH LTB4R2+protein,+human
  • MeSH Receptors,+Leukotriene+B4
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)