Prostaglandinski F receptor

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Prostaglandinski F receptor (FP)
Identifikatori
SimboliPTGFR; FP
Vanjski IDOMIM: 600563 MGI: 97796 HomoloGene: 741 IUPHAR: FP GeneCards: PTGFR Gene
Ontologija gena
Molekularna funkcija • aktivnost prostaglandinskog F receptora
Celularna komponenta • ekstracelularni region
• citoplazma
• ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • signalni put G-protein spregnutog receptora
• porođaj
• respons na lipopolisaharid
• negativna regulacija apoptotičkog procesa
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez573719220
EnsemblENSG00000122420ENSMUSG00000028036
UniProtP43088P43117
RefSeq (mRNA)NM_000959.3NM_008966.3
RefSeq (protein)NP_000950.1NP_032992.1
Lokacija (UCSC)Chr 1:
78.77 - 79.01 Mb		Chr 3:
151.46 - 151.5 Mb
PubMed pretraga[1][2]

Prostaglandinski F receptor (FP) je receptor za prostaglandin F2α. On je kodiran PTGFR genom.[1]

Ovaj protein je član familije G protein spregnutih receptora.

Dve transkriptne varijante koji kodiraju različite izoforme su nađene za ovaj gen.[1]

Funkcije

Glavni efekti vezivanja prostaglandina za ovaj receptor su:

  • kontrakcija materice
  • bronhokonstrikcija[2]

Putem aktivacije ovog receptora, PGF2-alfa posreduje luteolizu[1], i može da učestvuje u modulaciji intraokularnog pritiska i kontrakcija glatkih mišića materice i sfinktera gastrointestinalnog trakta[3].

Ispitivanja na nokaut miševima sugeriraju da interakcije PGF2-alfa sa ovim receptorom u lutealnim ćelijama jajnika iniciraju luteolizu i tako indukuju porođaj.[4]

Reference

  1. ↑ 1,0 1,1 1,2 „Entrez Gene: PTGFR prostaglandin F receptor (FP)”. 
  2. ↑ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5:th ed., Churchill Livingstone 2003) Page 234
  3. ↑ Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
  4. ↑ Sugimoto Y, Yamasaki A, Segi E i dr.. (1997). „Failure of parturition in mice lacking the prostaglandin F receptor”. Science 277 (5326): 681–3. DOI:10.1126/science.277.5326.681. PMID 9235889. 

Literatura

  • Duncan AM, Anderson LL, Funk CD i dr.. (1995). „Chromosomal localization of the human prostanoid receptor gene family”. Genomics 25 (3): 740–2. DOI:10.1016/0888-7543(95)80022-E. PMID 7759114. 
  • Lake S, Gullberg H, Wahlqvist J i dr.. (1995). „Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor”. FEBS Lett. 355 (3): 317–25. DOI:10.1016/0014-5793(94)01198-2. PMID 7988697. 
  • Bastien L, Sawyer N, Grygorczyk R i dr.. (1994). „Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype”. J. Biol. Chem. 269 (16): 11873–7. PMID 8163486. 
  • Funk CD, Furci L, FitzGerald GA i dr.. (1994). „Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype”. J. Biol. Chem. 268 (35): 26767–72. PMID 8253813. 
  • Abramovitz M, Boie Y, Nguyen T i dr.. (1994). „Cloning and expression of a cDNA for the human prostanoid FP receptor”. J. Biol. Chem. 269 (4): 2632–6. PMID 8300593. 
  • Sugimoto Y, Yamasaki A, Segi E i dr.. (1997). „Failure of parturition in mice lacking the prostaglandin F receptor”. Science 277 (5326): 681–3. DOI:10.1126/science.277.5326.681. PMID 9235889. 
  • Kunapuli P, Lawson JA, Rokach J, FitzGerald GA (1997). „Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha”. J. Biol. Chem. 272 (43): 27147–54. DOI:10.1074/jbc.272.43.27147. PMID 9341156. 
  • Betz R, Lagercrantz J, Kedra D i dr.. (1999). „Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene”. Biochem. Biophys. Res. Commun. 254 (2): 413–6. DOI:10.1006/bbrc.1998.9827. PMID 9918852. 
  • Kyveris A, Maruscak E, Senchyna M (2002). „Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR”. Mol. Vis. 8: 51–8. PMID 11951086. 
  • Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Neuschäfer-Rube F, Engemaier E, Koch S i dr.. (2003). „Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor”. Biochem. J. 371 (Pt 2): 443–9. DOI:10.1042/BJ20021429. PMC 1223288. PMID 12519077. 
  • Zaragoza DB, Wilson R, Eyster K, Olson DM (2004). „Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene”. Biochim. Biophys. Acta 1676 (2): 193–202. DOI:10.1016/j.bbaexp.2003.11.004. PMID 14746914. 
  • Sales KJ, Milne SA, Williams AR i dr.. (2004). „Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways”. J. Clin. Endocrinol. Metab. 89 (2): 986–93. DOI:10.1210/jc.2003-031434. PMID 14764825. 
  • Vielhauer GA, Fujino H, Regan JW (2004). „Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor”. Arch. Biochem. Biophys. 421 (2): 175–85. DOI:10.1016/j.abb.2003.10.021. PMID 14984197. 
  • Jin P, Fu GK, Wilson AD i dr.. (2004). „PCR isolation and cloning of novel splice variant mRNAs from known drug target genes”. Genomics 83 (4): 566–71. DOI:10.1016/j.ygeno.2003.09.023. PMID 15028279. 
  • Sugino N, Karube-Harada A, Taketani T i dr.. (2004). „Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation”. J. Reprod. Dev. 50 (2): 215–25. DOI:10.1262/jrd.50.215. PMID 15118249. 
  • Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Scott G, Jacobs S, Leopardi S i dr.. (2005). „Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation”. Exp. Cell Res. 304 (2): 407–16. DOI:10.1016/j.yexcr.2004.11.016. PMID 15748887. 
  • Mandal AK, Ray R, Zhang Z i dr.. (2005). „Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators”. J. Biol. Chem. 280 (38): 32897–904. DOI:10.1074/jbc.M502375200. PMID 16061484. 
  • Hébert RL, Carmosino M, Saito O, et al. (2005). „Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct.”. J. Biol. Chem. 280 (41): 35028–37. DOI:10.1074/jbc.M505852200. PMID 16096282. 

Vidi još

Spoljašnje veze

  • „Prostanoid Receptors: FP”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
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  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)