GPR37

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G protein-spregnuti receptor 37
Identifikatori
SimboliGPR37; EDNRBL; PAELR; hET(B)R-LP
Vanjski IDOMIM: 602583 MGI: 1313297 HomoloGene: 3875 IUPHAR: GPR37 GeneCards: GPR37 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu sličnog receptora
• receptorska aktivnost
• aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez286114763
EnsemblENSG00000170775ENSMUSG00000039904
UniProtO15354Q9QY42
RefSeq (mRNA)NM_005302NM_010338
RefSeq (protein)NP_005293NP_034468
Lokacija (UCSC)Chr 7:
124.17 - 124.19 Mb		Chr 6:
25.62 - 25.64 Mb
PubMed pretraga[1][2]

GPR37, G protein-spregnuti receptor 37, je protein koji je kod čoveka kodiran GPR37 genom.[1][2]

Interakcije

Za GPR37 je pokazano da interaguje sa HSPA1A[3] i parkin ligazom.[3][4]

Literatura

  1. ↑ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (November 1997). „Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library”. Genomics 45 (1): 68–77. DOI:10.1006/geno.1997.4900. PMID 9339362. 
  2. ↑ „Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)”. 
  3. ↑ 3,0 3,1 Imai, Yuzuru; Soda Mariko, Hatakeyama Shigetsugu, Akagi Takumi, Hashikawa Tsutomu, Nakayama Kei Ichi, Takahashi Ryosuke (July 2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity”. Mol. Cell (United States) 10 (1): 55–67. DOI:10.1016/S1097-2765(02)00583-X. ISSN 1097-2765. PMID 12150907. 
  4. ↑ Imai, Y; Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (June 2001). „An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin”. Cell (United States) 105 (7): 891–902. DOI:10.1016/S0092-8674(01)00407-X. ISSN 0092-8674. PMID 11439185. 

Dodatna literatura

  • Zeng Z, Su K, Kyaw H, Li Y (1997). „A novel endothelin receptor type-B-like gene enriched in the brain.”. Biochem. Biophys. Res. Commun. 233 (2): 559–67. DOI:10.1006/bbrc.1997.6408. PMID 9144577. 
  • Donohue PJ, Shapira H, Mantey SA, et al. (1998). „A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system.”. Brain Res. Mol. Brain Res. 54 (1): 152–60. DOI:10.1016/S0169-328X(97)00336-7. PMID 9526070. 
  • Imai Y, Soda M, Inoue H, et al. (2001). „An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.”. Cell 105 (7): 891–902. DOI:10.1016/S0092-8674(01)00407-X. PMID 11439185. 
  • Imai Y, Soda M, Hatakeyama S, et al. (2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.”. Mol. Cell 10 (1): 55–67. DOI:10.1016/S1097-2765(02)00583-X. PMID 12150907. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Yang Y, Nishimura I, Imai Y, et al. (2003). „Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.”. Neuron 37 (6): 911–24. DOI:10.1016/S0896-6273(03)00143-0. PMID 12670421. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7.”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948. 
  • Imai Y, Soda M, Murakami T, et al. (2004). „A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.”. J. Biol. Chem. 278 (51): 51901–10. DOI:10.1074/jbc.M309655200. PMID 14532270. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Kubota K, Niinuma Y, Kaneko M, et al. (2006). „Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.”. J. Neurochem. 97 (5): 1259–68. DOI:10.1111/j.1471-4159.2006.03782.x. PMID 16539653. 
  • Omura T, Kaneko M, Okuma Y, et al. (2007). „A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.”. J. Neurochem. 99 (6): 1456–69. DOI:10.1111/j.1471-4159.2006.04155.x. PMID 17059562. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)