Neuropeptidni FF receptor 2

edit
Neuropeptidni FF receptor 2
Identifikatori
SimboliNPFFR2; GPR74; NPFF2; NPGPR
Vanjski IDOMIM: 607449 MGI: 1860130 HomoloGene: 56982 IUPHAR: NPFF2 GeneCards: NPFFR2 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• receptorska aktivnost
• aktivnost neuropeptidnog receptora
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• detekcija abiotičkog stimulusa
Ortolozi
VrstaČovekMiš
Entrez10886104443
EnsemblENSG00000056291ENSMUSG00000035528
UniProtQ9Y5X5Q924N0
RefSeq (mRNA)NM_004885XM_973847
RefSeq (protein)NP_004876XP_978941
Lokacija (UCSC)Chr 4:
73.12 - 73.23 Mb		Chr 5:
90.6 - 90.66 Mb
PubMed pretraga[1][2]

Neuropeptidni FF receptor 2 (NPFF2) je humani protein kodiran NPFFR2 genom.[1]

Vidi još

  • Neuropeptidni FF receptor

Reference

  1. ↑ „Entrez Gene: NPFFR2 neuropeptide FF receptor 2”. 

Literatura

  • Cikos S, Gregor P, Koppel J (1999). „Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta.”. Biochem. Biophys. Res. Commun. 256 (2): 352–6. DOI:10.1006/bbrc.1999.0332. PMID 10079187. 
  • Parker RM, Copeland NG, Eyre HJ, et al. (2000). „Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family.”. Brain Res. Mol. Brain Res. 77 (2): 199–208. DOI:10.1016/S0169-328X(00)00052-8. PMID 10837915. 
  • Elshourbagy NA, Ames RS, Fitzgerald LR, et al. (2000). „Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.”. J. Biol. Chem. 275 (34): 25965–71. DOI:10.1074/jbc.M004515200. PMID 10851242. 
  • Bonini JA, Jones KA, Adham N, et al. (2001). „Identification and characterization of two G protein-coupled receptors for neuropeptide FF.”. J. Biol. Chem. 275 (50): 39324–31. DOI:10.1074/jbc.M004385200. PMID 11024015. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Laemmle B, Schindler M, Beilmann M, et al. (2003). „Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus.”. Regul. Pept. 111 (1–3): 21–9. DOI:10.1016/S0167-0115(02)00220-3. PMID 12609745. 
  • Engström M, Wurster S, Savola JM, Panula P (2004). „Functional properties of Pfr(Tic)amide and BIBP3226 at human neuropeptide FF2 receptors”. Peptides 24 (12): 1947–54. DOI:10.1016/j.peptides.2003.10.009. PMID 15127947. 
  • Mollereau C, Mazarguil H, Zajac JM, Roumy M (2005). „Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells”. Mol. Pharmacol. 67 (3): 965–75. DOI:10.1124/mol.104.004614. PMID 15608144. 
  • Ankö ML, Panula P (2006). „Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line”. J. Neurochem. 96 (2): 573–84. DOI:10.1111/j.1471-4159.2005.03581.x. PMID 16336216. 
  • Ankö ML, Ostergård M, Lintunen M, Panula P (2007). „Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression”. FEBS Lett. 580 (30): 6955–60. DOI:10.1016/j.febslet.2006.11.063. PMID 17157836. 
  • Dahlman I, Dicker A, Jiao H, et al. (2007). „A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis”. Am. J. Hum. Genet. 80 (6): 1115–24. DOI:10.1086/518445. PMC 1867099. PMID 17503329. 

Spoljašnje veze

  • „Neuropeptide FF Receptors: NPFF2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
  • p
  • r
  • u
Neuropeptidni receptori
Hormonski receptori
Drugi
Opioidni receptori
Drugi neuropeptidni receptori
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)