TAS2R38

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Receptor ukusa tip 2 član 38
Identifikatori
SimboliTAS2R38; PTC; T2R38; T2R61
Vanjski IDOMIM: 607751 MGI: 2681306 HomoloGene: 47976 IUPHAR: GeneCards: TAS2R38 Gene
Ontologija gena
Molekularna funkcija • aktivnost receptora ukusa
Celularna komponenta • integralno sa membranom
Biološki proces • signalni put G-protein spregnutog receptora
Ortolozi
VrstaČovekMiš
Entrez5726387513
EnsemblENSG00000257138ENSMUSG00000058250
UniProtP59533Q7TQA6
RefSeq (mRNA)NM_176817.4NM_001001451.1
RefSeq (protein)NP_789787.4NP_001001451.1
Lokacija (UCSC)Chr 7:
141.67 - 141.67 Mb		Chr 6:
40.56 - 40.56 Mb
PubMed pretraga[1][2]

Receptor ukusa tip 2 član 38 je protein koji je kod ljudi kodiran TAS2R38 genom. TAS2R38 je receptor gorkog ukusa. Različiti genotipi ovog receptora utiču na sposobnost prepoznavanja ukusa 6-n-propiltiouracila (PROP)[1] i feniltiokarbamida (PTC).[2][3] Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the only taste receptors shown to have this function.[4]

Prenos signala

Kao i kod svih TAS2R proteina, TAS2R38 koristi G-protein gustducin kao svoj primarni metod prenosa signala. Jedinice α i βγ su esencijalne za prenos signala ukusa.[5]

Reference

  1. ↑ Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). „Bitter Receptor Gene (TAS2R38), 6-n-Propylthiouracil (PROP) Bitterness and Alcohol Intake”. Alcoholism, clinical and experimental research 28 (11): 1629–1637. DOI:10.1097/01.ALC.0000145789.55183.D4. PMC 1397913. PMID 15547448. 
  2. ↑ Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). „Bitter Taste Study in a Sardinian Genetic Isolate Supports the Association of Phenylthiocarbamide Sensitivity to the TAS2R38 Bitter Receptor Gene”. Chemical Senses 29 (8): 697–702. DOI:10.1093/chemse/bjh074. PMID 15466815. 
  3. ↑ Kim UK, Drayna D (2004). „Genetics of individual differences in bitter taste perception: Lessons from the PTC gene”. Clinical Genetics 67 (4): 275–280. DOI:10.1111/j.1399-0004.2004.00361.x. PMID 15733260. 
  4. ↑ Bachmanov AA, Beauchamp GK (2007). „Taste Receptor Genes”. Annual Review of Nutrition 27: 389–414. DOI:10.1146/annurev.nutr.26.061505.111329. PMC 2721271. PMID 17444812. 
  5. ↑ Margolskee RF (2001). „Molecular Mechanisms of Bitter and Sweet Taste Transduction”. Journal of Biological Chemistry 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554. 

Literatura

  • Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982. 
  • Anne-Spence M, Falk CT, Neiswanger K, et al. (1984). „Estimating the recombination frequency for the PTC-Kell linkage”. Hum. Genet. 67 (2): 183–6. DOI:10.1007/BF00272997. PMID 6745938. 
  • Bufe B, Hofmann T, Krautwurst D, et al. (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat. Genet. 32 (3): 397–401. DOI:10.1038/ng1014. PMID 12379855. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520. 
  • Conte C, Ebeling M, Marcuz A, et al. (2003). „Identification and characterization of human taste receptor genes belonging to the TAS2R family”. Cytogenet. Genome Res. 98 (1): 45–53. DOI:10.1159/000068546. PMID 12584440. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human Chromosome 7: DNA Sequence and Biology”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205. 
  • Pronin AN, Tang H, Connor J, Keung W (2005). „Identification of ligands for two human bitter T2R receptors”. Chem. Senses 29 (7): 583–93. DOI:10.1093/chemse/bjh064. PMID 15337684. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549. 
  • Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics 170 (1): 313–26. DOI:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053. 

Spoljašnje veze

  • MeSH TAS2R38+protein,+human
  • TAS2R38 Gene Card
  • TAS2R38 OMIM Page

Vidi još

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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)