FZD8

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Uvojiti receptor 8

PDB rendering based on 1ijy.

Dostupne strukture

1ijy

Identifikatori

Simboli

FZD8; FZ-8; hFZ8

Vanjski ID

OMIM: 606146 MGI: 108460 HomoloGene: 40606 IUPHAR: FZD₈ GeneCards: FZD8 Gene

Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora • receptorsko vezivanje • proteinsko vezivanje • Wnt proteinsko vezivanje • vezivanje PDZ domena
Celularna komponenta	• citoplazma • ćelijska površina • integralno sa membranom • sinaptosom • membrana neuronske projekcije
Biološki proces	• pozitivna regulacija proteinske fosforilacije • razvoj vaskulature • morfogeneza odlivnog trakta • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

8325

14370

Ensembl

ENSG00000177283

ENSMUSG00000036904

UniProt

Q9H461

Q61091

RefSeq (mRNA)

NM_031866.2

NM_008058.2

RefSeq (protein)

NP_114072.1

NP_032084.2

Lokacija (UCSC)

Chr 10:
35.93 - 35.93 Mb

Chr 18:
9.21 - 9.22 Mb

PubMed pretraga

[1]

[2]

Uvojiti-8 je protein koji je kod ljudi kodiran FZD8 genom.^[1]^[2]

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD8 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. Ovaj gen je visoko izražen u dva tipa ćelija ljudskog kancera. Kristalna struktura ekstracelularnog, cisteinom-bogatog domena, srodnog mišjeg proteina je određena.^[2]

Reference

↑ Saitoh T, Hirai M, Katoh M (Apr 2001). „Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2”. Int J Oncol 18 (5): 991–6. PMID 11295046.
↑ ^2,0 ^2,1 „Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)”.

Literatura

Wang Y, Macke JP, Abella BS i dr.. (1996). „A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled”. J. Biol. Chem. 271 (8): 4468–4476. DOI:10.1074/jbc.271.8.4468. PMID 8626800.
Finch PW, He X, Kelley MJ i dr.. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–6775. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
Tamai K, Semenov M, Kato Y i dr.. (2000). „LDL-receptor-related proteins in Wnt signal transduction”. Nature 407 (6803): 530–535. DOI:10.1038/35035117. PMID 11029007.
Hartley JL, Temple GF, Brasch MA (2001). „DNA cloning using in vitro site-specific recombination”. Genome Res. 10 (11): 1788–1795. DOI:10.1101/gr.143000. PMC 310948. PMID 11076863.
Semënov MV, Tamai K, Brott BK i dr.. (2001). „Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6”. Curr. Biol. 11 (12): 951–961. DOI:10.1016/S0960-9822(01)00290-1. PMID 11448771.
Dann CE, Hsieh JC, Rattner A i dr.. (2001). „Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains”. Nature 412 (6842): 86–90. DOI:10.1038/35083601. PMID 11452312.
Yao R, Maeda T, Takada S, Noda T (2001). „Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled”. Biochem. Biophys. Res. Commun. 286 (4): 771–778. DOI:10.1006/bbrc.2001.5430. PMID 11520064.
Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV i dr.. (2004). „The DNA sequence and comparative analysis of human chromosome 10”. Nature 429 (6990): 375–381. DOI:10.1038/nature02462. PMID 15164054.
Omoto S, Hayashi T, Kitahara K i dr.. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539.
Lu W, Yamamoto V, Ortega B, Baltimore D (2004). „Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth”. Cell 119 (1): 97–108. DOI:10.1016/j.cell.2004.09.019. PMID 15454084.

Vidi još

Uvojiti receptori

Spoljašnje veze

„Frizzled Receptors: FZD₈”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-09-03.

PDB Galerija

1ijy: Kristalna struktura cisteinom bogatog domena mišjeg uvojitog receptora 8 (MFZ8)

Transmembranski receptor: G protein spregnuti receptori

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan

GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)

Drugi

Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4)

Klasa F:
Frizzled / Zaglađeni

Uvojiti	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni	Zaglađeni

B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)