GPR65

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G protein-spregnuti receptor 65
Identifikatori
SimboliGPR65; TDAG8; hTDAG8
Vanjski IDOMIM: 604620 MGI: 108031 HomoloGene: 2675 IUPHAR: GPR65 GeneCards: GPR65 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu sličnog receptora
• receptorska aktivnost
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • apoptoza
• imunski respons
• prenos signala
• signalni put G-protein spregnutog receptora
• razvoj višećelijskih organizama
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez847714744
EnsemblENSG00000140030ENSMUSG00000021886
UniProtQ8IYL9Q3UQ35
RefSeq (mRNA)NM_003608NM_008152
RefSeq (protein)NP_003599NP_032178
Lokacija (UCSC)Chr 14:
87.54 - 87.55 Mb		Chr 12:
98.67 - 98.68 Mb
PubMed pretraga[1][2]

GPR65, G protein-spregnuti receptor 65, ili psihozinski receptor, je protein koji je kod čoveka kodiran GPR65 genom.[1][2]

Vidi još

Literatura

  1. ↑ Kyaw H, Zeng Z, Su K, Fan P, Shell BK, Carter KC, Li Y (Jul 1998). „Cloning, characterization, and mapping of human homolog of mouse T-cell death-associated gene”. DNA Cell Biol 17 (6): 493–500. DOI:10.1089/dna.1998.17.493. PMID 9655242. 
  2. ↑ „Entrez Gene: GPR65 G protein-coupled receptor 65”. 

Dodatna literatura

  • Im DS, Heise CE, Nguyen T, et al. (2001). „Identification of a molecular target of psychosine and its role in globoid cell formation.”. J. Cell Biol. 153 (2): 429–34. DOI:10.1083/jcb.153.2.429. PMC 2169470. PMID 11309421. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). „The DNA sequence and analysis of human chromosome 14.”. Nature 421 (6923): 601–7. DOI:10.1038/nature01348. PMID 12508121. 
  • Sin WC, Zhang Y, Zhong W, et al. (2004). „G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers.”. Oncogene 23 (37): 6299–303. DOI:10.1038/sj.onc.1207838. PMID 15221007. 
  • Wang JQ, Kon J, Mogi C, et al. (2004). „TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor.”. J. Biol. Chem. 279 (44): 45626–33. DOI:10.1074/jbc.M406966200. PMID 15326175. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Ishii S, Kihara Y, Shimizu T (2005). „Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor.”. J. Biol. Chem. 280 (10): 9083–7. DOI:10.1074/jbc.M407832200. PMID 15618224. 
  • Radu CG, Nijagal A, McLaughlin J, et al. (2005). „Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.”. Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. DOI:10.1073/pnas.0409415102. PMC 545089. PMID 15665078. 
  • p
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)