S1PR5

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Sfingozin 1-fosfatni receptor 5
Identifikatori
SimboliS1PR5; EDG8; Edg-8; S1P5; SPPR-1; SPPR-2
Vanjski IDOMIM: 605146 MGI: 2150641 HomoloGene: 11031 IUPHAR: S1P5 GeneCards: S1PR5 Gene
Ontologija gena
Molekularna funkcija • aktivnost G-protein spregnutog receptora
• aktivnost faktora guanil-nukleotidne razmene
• vezivanje masne kiseline
Celularna komponenta • ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • metabolički proces energetske rezerve
• signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez5363794226
EnsemblENSG00000180739ENSMUSG00000045087
UniProtQ9H228Q91X56
RefSeq (mRNA)NM_001166215.1NM_053190.2
RefSeq (protein)NP_001159687.1NP_444420.1
Lokacija (UCSC)Chr 19:
10.62 - 10.63 Mb		Chr 9:
21.05 - 21.05 Mb
PubMed pretraga[1][2]

Sfingozin 1-fosfat receptor 5 (S1PR5) je ljudski gen koji kodira G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin 1-fosfat (S1P).[1]

Reference

  1. ↑ „Entrez Gene: S1PR5 Sphingosine-1-phosphate receptor 5”. 

Literatura

  • Im DS, Heise CE, Ancellin N, et al. (2000). „Characterization of a novel sphingosine 1-phosphate receptor, Edg-8.”. J. Biol. Chem. 275 (19): 14281–6. DOI:10.1074/jbc.275.19.14281. PMID 10799507. 
  • Malek RL, Toman RE, Edsall LC, et al. (2001). „Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors.”. J. Biol. Chem. 276 (8): 5692–9. DOI:10.1074/jbc.M003964200. PMID 11069896. 
  • Hla T (April 2001). Sphingosine 1-phosphate receptors.. 64. pp. 135–142. PMID 11331101. 
  • Im DS, Clemens J, Macdonald TL, Lynch KR (2001). „Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors.”. Biochemistry 40 (46): 14053–60. DOI:10.1021/bi011606i. PMID 11705398. 
  • Takeda S, Kadowaki S, Haga T, et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence.”. FEBS Lett. 520 (1-3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
  • Niedernberg A, Scherer CR, Busch AE, Kostenis E (2002). „Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists.”. Biochem. Pharmacol. 64 (8): 1243–50. DOI:10.1016/S0006-2952(02)01289-3. PMID 12234605. 
  • Kothapalli R, Kusmartseva I, Loughran TP (2003). „Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia.”. Biochim. Biophys. Acta 1579 (2-3): 117–23. DOI:10.1016/S0167-4781(02)00529-8. PMID 12427546. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Vogler R, Sauer B, Kim DS, et al. (2003). „Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.”. J. Invest. Dermatol. 120 (4): 693–700. DOI:10.1046/j.1523-1747.2003.12096.x. PMID 12648236. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). „The DNA sequence and biology of human chromosome 19.”. Nature 428 (6982): 529–35. DOI:10.1038/nature02399. PMID 15057824. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Ulfig N, Briese M (2005). „Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers.”. Acta Histochem. 106 (5): 373–8. DOI:10.1016/j.acthis.2004.08.002. PMID 15530552. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”. DNA Res. 12 (2): 117–26. DOI:10.1093/dnares/12.2.117. PMID 16303743. 

Vidi još

Spoljašnje veze

  • „Lysophospholipid Receptors: S1P5”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2015-12-08. 
  • MeSH Lysophospholipid+receptors
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)