S1PR3

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Sfingozin-1-fosfatni receptor 3

Identifikatori

S1PR3; EDG-3; EDG3; LPB3; S1P3

Vanjski ID

OMIM: 601965 MGI: 1339365 HomoloGene: 3829 IUPHAR: S₁P₃

Ontologija gena
Molekularna funkcija	• aktivnost G-protein spregnutog receptora • aktivnost faktora guanil-nukleotidne razmene • vezivanje masne kiseline
Celularna komponenta	• ćelijska membrana • integralno sa ćelijskom membranom
Biološki proces	• metabolički proces energetske rezerve • signalni put G-protein spregnutog receptora • pozitivna regulacija kalcijumskog jonskog transporta u citozol

Ortolozi

Vrsta

Čovek

Miš

Entrez

n/a

13610

Ensembl

ENSG00000213694

ENSMUSG00000067586

UniProt

Q99500

Q9Z0U9

RefSeq (mRNA)

NM_005226.3

NM_010101.4

RefSeq (protein)

NP_005217.2

NP_034231.1

Lokacija (UCSC)

Chr 9:
91.61 - 91.62 Mb

Chr 13:
51.5 - 51.52 Mb

PubMed pretraga

n/a

[1]

Sfingozin-1-fosfatni receptor 3 je ljudski gen koji kodira G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin 1-fosfat (S1P). stoga je ovaj receptor takođe poznat kao S1P₃.^[1]

Funkcija

Ovaj protein je član EDG familije receptora. On doprinosi regulaciji angiogeneze i funkcija vaskularnih endotelnih ćelija.^[1]

Reference

↑ ^1,0 ^1,1 „Entrez Gene: S1PR3 sphingosine-1-phosphate receptor 3”.

Literatura

Hla T, Lee MJ, Ancellin N, et al. (2000). „Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors.”. Ann. N. Y. Acad. Sci. 905: 16–24. DOI:10.1111/j.1749-6632.2000.tb06534.x. PMID 10818438.
Spiegel S (2000). „Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.”. Ann. N. Y. Acad. Sci. 905: 54–60. DOI:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441.
Watsky MA, Griffith M, Wang DA, Tigyi GJ (2000). „Phospholipid growth factors and corneal wound healing.”. Ann. N. Y. Acad. Sci. 905: 142–58. DOI:10.1111/j.1749-6632.2000.tb06546.x. PMID 10818450.
Takuwa Y (2002). „[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]”. Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496–502. PMID 11915348.
Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, et al. (1996). „A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.”. Mol. Pharmacol. 49 (6): 956–61. PMID 8649355.
Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). „Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.”. Biochem. Biophys. Res. Commun. 227 (2): 608–14. DOI:10.1006/bbrc.1996.1553. PMID 8878560.
An S, Bleu T, Huang W, et al. (1998). „Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.”. FEBS Lett. 417 (3): 279–82. DOI:10.1016/S0014-5793(97)01301-X. PMID 9409733.
Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999). „Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.”. J. Biol. Chem. 274 (8): 4626–32. DOI:10.1074/jbc.274.8.4626. PMID 9988698.
Zhang Q, Peyruchaud O, French KJ, et al. (1999). „Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway.”. Blood 93 (9): 2984–90. PMID 10216094.
Ancellin N, Hla T (1999). „Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.”. J. Biol. Chem. 274 (27): 18997–9002. DOI:10.1074/jbc.274.27.18997. PMID 10383399.
Windh RT, Lee MJ, Hla T, et al. (1999). „Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.”. J. Biol. Chem. 274 (39): 27351–8. DOI:10.1074/jbc.274.39.27351. PMID 10488065.
Goetzl EJ, Dolezalova H, Kong Y, et al. (1999). „Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.”. Cancer Res. 59 (20): 5370–5. PMID 10537322.
Lee MJ, Thangada S, Claffey KP, et al. (1999). „Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.”. Cell 99 (3): 301–12. DOI:10.1016/S0092-8674(00)81661-X. PMID 10555146.
An S, Zheng Y, Bleu T (2000). „Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.”. J. Biol. Chem. 275 (1): 288–96. DOI:10.1074/jbc.275.1.288. PMID 10617617.
Orlati S, Porcelli AM, Hrelia S, et al. (2000). „Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor.”. Arch. Biochem. Biophys. 375 (1): 69–77. DOI:10.1006/abbi.1999.1589. PMID 10683250.
Lee H, Goetzl EJ, An S (2000). „Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing.”. Am. J. Physiol., Cell Physiol. 278 (3): C612–8. PMID 10712250.
Kimura T, Watanabe T, Sato K, et al. (2000). „Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.”. Biochem. J. 348 Pt 1: 71–6. DOI:10.1042/0264-6021:3480071. PMID 10794715.

Vidi još

Lizofosfolipidni receptor

Spoljašnje veze

„Lysophospholipid Receptors: S₁P₃”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
MeSH Lysophospholipid+receptors

Transmembranski receptor: G protein spregnuti receptori

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Orfan

GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)

Drugi

Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4)

Klasa F:
Frizzled / Zaglađeni

Uvojiti	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni	Zaglađeni

B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)