Transferinski receptor
| Transferinski receptor (p90, CD71) | |
|---|---|
 | |
| Dimer transferinskog receptora 1 (čovjek) | |
| Identifikatori | |
| Simbol | TFRC |
| Alt. simboli | CD71, TFR1 |
| Entrez | 7037 |
| HUGO | 11763 |
| OMIM | 190010 |
| RefSeq | NM_003234 |
| UniProt | P02786 |
| Drugi podaci | |
| Lokus | Hromozom 3 q29 |
| Transferinski receptor 2 | |
|---|---|
| Identifikatori | |
| Simbol | TFR2 |
| Alt. simboli | HFE3, TFRC2 |
| Entrez | 7036 |
| Hugo | 11762 |
| OMIM | 604720 |
| RefSek | NM_003227 |
| UniProt | Q9UP52 |
| Drugi podaci | |
| Lokus | Hrom. 7 q22 |
Transferinski receptor (TfR) je prenosni protein za transferin. On je potreban za unos gvožđa u ćeliju i kontrolisan je intraćelijskom koncentracijom gvožđa. On unosi gvožđe internalizacijom kompleksa transferin-gvožđe putem endocitoze posredovane receptorom.[1]
Regulacija
Niske koncentracije gvožđa podstiču povećanje nivoa transferinskog receptora, da bi se povećao unos gvožđa u ćeliju. Transferinski receptor učestvuje u održavanju ćelijske homeostaze gvožđa.
TfR produkcija u ćeliji je regulisana nivoima gvožđa posredstvom IRE-BP proteina (respons na gvožđe/regulatorni element vezivanja proteina), koji se naziva i regulatorni protein gvožđa (engl. Iron Regulatory Protein - IRP). Taj protein se vezuje za strukturu sličnu ukosnici na 3' UTR TfR receptora. Nakon vezivanja dolazi do inhibicije degradacije iRNK za IRE.
Reference
- ↑ Qian ZM, Li H, Sun H, Ho K (December 2002). „Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway”. Pharmacol. Rev. 54 (4): 561–87. DOI:10.1124/pr.54.4.561. PMID 12429868. ; Figure 3: The cycle of transferrin and transferrin receptor 1-mediated cellular iron uptake.[mrtav link]
Literatura
- Testa U, Kühn L, Petrini M, Quaranta MT, Pelosi E, Peschle C (July 1991). „Differential regulation of iron regulatory element-binding protein(s) in cell extracts of activated lymphocytes versus monocytes-macrophages”. J. Biol. Chem. 266 (21): 13925–30. PMID 1856222.
- Daniels TR, Delgado T, Rodriguez JA, Helguera G, Penichet ML (November 2006). „The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer”. Clin. Immunol. 121 (2): 144–58. DOI:10.1016/j.clim.2006.06.010. PMID 16904380. ; Figure 3: Cellular uptake of iron through the Tf system via receptor-mediated endocytosis. Arhivirano 2015-09-24 na Wayback Machine-u
- Daniels TR, Delgado T, Helguera G, Penichet ML (November 2006). „The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells”. Clin. Immunol. 121 (2): 159–76. DOI:10.1016/j.clim.2006.06.006. PMID 16920030.
Vidi još
Spoljašnje veze
- MeSH Transferrin+receptor
- Okam M (29. 01. 2001.). „Transerrin and Iron Transport Physiology”. Information Center for Sickle Cell and Thalassemic Disorders. Brigham and Women's Hospital and Harvard Medical School. Pristupljeno 19. 12. 2010.
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CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • CD15 • CD16 (A, B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50
CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E, L, P) • CD63 • CD64 (A, B, C) • CD66 (a, b, c, d, e, f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a, b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a, b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a, b) • CD121 (a, b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a, b, c) • CD157 • CD158 (a, d, e, i, k) • CD159 (a, c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a, b) • CD168 • CD169 • CD170 • CD171 • CD172 (a, b, g) • CD174 • CD177 • CD178 • CD179 (a, b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a, b) • CD212 • CD213a (1, 2) • CD217 • CD218 (a, b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a, b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247- CD248 • CD249
CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
