Receptor insulinu sličnog faktora rasta 1
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| Receptor insulinu sličnog faktora rasta 1 | |||||||||||
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 Prva tri domena receptora insulinu sličnog faktora rasta 1. PDB prikaz baziran na 1igr. | |||||||||||
| Dostupne strukture | |||||||||||
| 1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU | |||||||||||
| Identifikatori | |||||||||||
| Simboli | IGF1R; CD221; IGFIR; IGFR; JTK13 | ||||||||||
| Vanjski ID | OMIM: 147370 MGI: 96433 HomoloGene: 30997 GeneCards: IGF1R Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 3480 | 16001 | |||||||||
| Ensembl | ENSG00000140443 | ENSMUSG00000005533 | |||||||||
| UniProt | P08069 | Q60751 | |||||||||
| RefSeq (mRNA) | NM_000875.3 | NM_010513.2 | |||||||||
| RefSeq (protein) | NP_000866.1 | NP_034643.2 | |||||||||
| Lokacija (UCSC) | Chr 15: 99.19 - 99.51 Mb | Chr 7: 67.95 - 68.23 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor insulinu sličnog faktora rasta 1 je protein koji je prisutan na površini ljudskih ćelija. On je transmembranski receptor koji se aktivira IGF-1 hormonom (insulinu sličan faktor rasta 1) i srodnim hormonom IGF-2. On pripada velikoj klasi tirozinsko kinaznih receptora . Ovaj receptor posreduje dejstvo IGF-1, koji je polipeptidni proteinski hormon sličan insulinu. IGF-1 utiče na razviće i nastavlja da vrši anaboličko dejstvo kod odraslih. On može da indukuje hipertroifju skeletalnih mišića i drugih ciljnih tkiva. Miševi bez IGF-1 receptora umiru u kasnijem periodu razvića, i manifestuju dramatičnu redukcu telesne mase, što potvrđuje jak uticaj ovog receptora. Miševi sa samo jednom funkcionalnom kopijom IGF1R su normalni, ali ispoljavaju ~15% umanjenje telesne mase.
Interakcije
Receptor insulinu sličnog faktora rasta 1 formira interakcije sa SOCS3,[1] PTPN11,[2][3] SOCS2,[4] GRB10,[5][6][7][8] PIK3R3,[9] C-src tirosinska kinaza,[10] EHD1,[11] Cbl genom,[12] RAS p21 proteinskim aktivatorom 1,[3] IRS1,[2][6][13] ARHGEF12,[14] YWHAE,[15] Mdm2,[12] SHC1[6][13][16] i NEDD4.[5][12]
Regulacija
Postoji evidencija da je IGF1R negativno regulisan dejstvom mikroRNK miR-7.[17]
References
- ↑ Dey, B R; Furlanetto R W, Nissley P (November 2000). „Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor”. Biochem. Biophys. Res. Commun. (UNITED STATES) 278 (1): 38–43. DOI:10.1006/bbrc.2000.3762. ISSN 0006-291X. PMID 11071852.
- ↑ 2,0 2,1 Mañes, S; Mira E, Gómez-Mouton C, Zhao Z J, Lacalle R A, Martínez-A C (April 1999). „Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility”. Mol. Cell. Biol. (UNITED STATES) 19 (4): 3125–35. ISSN 0270-7306. PMC 84106. PMID 10082579.
- ↑ 3,0 3,1 Seely, B L; Reichart D R, Staubs P A, Jhun B H, Hsu D, Maegawa H, Milarski K L, Saltiel A R, Olefsky J M (August 1995). „Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein”. J. Biol. Chem. (UNITED STATES) 270 (32): 19151–7. DOI:10.1074/jbc.270.32.19151. ISSN 0021-9258. PMID 7642582.
- ↑ Dey, B R; Spence S L, Nissley P, Furlanetto R W (September 1998). „Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor”. J. Biol. Chem. (UNITED STATES) 273 (37): 24095–101. DOI:10.1074/jbc.273.37.24095. ISSN 0021-9258. PMID 9727029.
- ↑ 5,0 5,1 Vecchione, Andrea; Marchese Adriano, Henry Pauline, Rotin Daniela, Morrione Andrea (May 2003). „The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor”. Mol. Cell. Biol. (United States) 23 (9): 3363–72. DOI:10.1128/MCB.23.9.3363-3372.2003. ISSN 0270-7306. PMC 153198. PMID 12697834.
- ↑ 6,0 6,1 6,2 Dey, B R; Frick K, Lopaczynski W, Nissley S P, Furlanetto R W (June 1996). „Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10”. Mol. Endocrinol. (UNITED STATES) 10 (6): 631–41. DOI:10.1210/me.10.6.631. ISSN 0888-8809. PMID 8776723.
- ↑ He, W; Rose D W, Olefsky J M, Gustafson T A (March 1998). „Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains”. J. Biol. Chem. (UNITED STATES) 273 (12): 6860–7. DOI:10.1074/jbc.273.12.6860. ISSN 0021-9258. PMID 9506989.
- ↑ Morrione, A; Valentinis B, Li S, Ooi J Y, Margolis B, Baserga R (July 1996). „Grb10: A new substrate of the insulin-like growth factor I receptor”. Cancer Res. (UNITED STATES) 56 (14): 3165–7. ISSN 0008-5472. PMID 8764099.
- ↑ Mothe, I; Delahaye L, Filloux C, Pons S, White M F, Van Obberghen E (December 1997). „Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins”. Mol. Endocrinol. (UNITED STATES) 11 (13): 1911–23. DOI:10.1210/me.11.13.1911. ISSN 0888-8809. PMID 9415396.
- ↑ Arbet-Engels, C; Tartare-Deckert S, Eckhart W (February 1999). „C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor”. J. Biol. Chem. (UNITED STATES) 274 (9): 5422–8. DOI:10.1074/jbc.274.9.5422. ISSN 0021-9258. PMID 10026153.
- ↑ Rotem-Yehudar, R; Galperin E, Horowitz M (August 2001). „Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29”. J. Biol. Chem. (United States) 276 (35): 33054–60. DOI:10.1074/jbc.M009913200. ISSN 0021-9258. PMID 11423532.
- ↑ 12,0 12,1 12,2 Sehat, Bita; Andersson Sandra, Girnita Leonard, Larsson Olle (July 2008). „Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis”. Cancer Res. (United States) 68 (14): 5669–77. DOI:10.1158/0008-5472.CAN-07-6364. PMID 18632619.
- ↑ 13,0 13,1 Tartare-Deckert, S; Sawka-Verhelle D, Murdaca J, Van Obberghen E (October 1995). „Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system”. J. Biol. Chem. (UNITED STATES) 270 (40): 23456–60. DOI:10.1074/jbc.270.40.23456. ISSN 0021-9258. PMID 7559507.
- ↑ Taya, S; Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K (November 2001). „Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF”. J. Cell Biol. (United States) 155 (5): 809–20. DOI:10.1083/jcb.200106139. ISSN 0021-9525. PMC 2150867. PMID 11724822.
- ↑ Craparo, A; Freund R, Gustafson T A (April 1997). „14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner”. J. Biol. Chem. (UNITED STATES) 272 (17): 11663–9. DOI:10.1074/jbc.272.17.11663. ISSN 0021-9258. PMID 9111084.
- ↑ Santen, R J; Song R X, Zhang Z, Kumar R, Jeng M-H, Masamura A, Lawrence J, Berstein L, Yue W (July 2005). „Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity”. Endocr. Relat. Cancer. 12 (England) Suppl 1 (Supplement_1): S61–73. DOI:10.1677/erc.1.01018. ISSN 1351-0088. PMID 16113100.
- ↑ Jiang, Lu; Liu, Xiqiang; Chen, Zujian; Jin, Yi; Heidbreder, Caroline E.; Kolokythas, Antonia; Wang, Anxun; Dai, Yang i dr.. (2010). „MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells”. Biochemical Journal 432 (1): 199–205. DOI:10.1042/BJ20100859. PMID 20819078.
Literatura
- Benito M, Valverde AM, Lorenzo M (1996). „IGF-I: a mitogen also involved in differentiation processes in mammalian cells.”. Int. J. Biochem. Cell Biol. 28 (5): 499–510. DOI:10.1016/1357-2725(95)00168-9. PMID 8697095.
- Butler AA, Yakar S, Gewolb IH, et al. (1999). „Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology.”. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 121 (1): 19–26. DOI:10.1016/S0305-0491(98)10106-2. PMID 9972281.
- Zhang X, Yee D (2001). „Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer.”. Breast Cancer Res. 2 (3): 170–5. DOI:10.1186/bcr50. PMC 138771. PMID 11250706.
- Gross JM, Yee D (2004). „The type-1 insulin-like growth factor receptor tyrosine kinase and breast cancer: biology and therapeutic relevance.”. Cancer Metastasis Rev. 22 (4): 327–36. DOI:10.1023/A:1023720928680. PMID 12884909.
- Adams TE, McKern NM, Ward CW (2005). „Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor.”. Growth Factors 22 (2): 89–95. DOI:10.1080/08977190410001700998. PMID 15253384.
- Surmacz E, Bartucci M (2005). „Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer.”. J. Exp. Clin. Cancer Res. 23 (3): 385–94. PMID 15595626.
- Wood AW, Duan C, Bern HA (2005). „Insulin-like growth factor signaling in fish.”. Int. Rev. Cytol. 243: 215–85. DOI:10.1016/S0074-7696(05)43004-1. PMID 15797461.
- Sarfstein R, Maor S, Reizner N, et al. (2006). „Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer.”. Mol. Cell. Endocrinol. 252 (1-2): 241–6. DOI:10.1016/j.mce.2006.03.018. PMID 16647191.
Vidi još
- Insulinski receptor
- Linzitinib, inhibitor IGF-1 u kliničkim ispitivanje za tretman kancera
Spoljašnje veze
- MeSH IGF-1+Receptor
- p
- r
- u
PDB Galerija
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