Izomeraza

U biohemiji, izomeraza je enzim koji katalizuje strukturno preuređenje izomera. Izomeraze katalizuju reakcije oblika:

A → B

gde je B izomer molekula A.

Nomenklatura

Imena izomeraza se formiraju kao „supstrat izomeraza“ (na primer, enoil CoA izomeraza), ili kao „supstrat tip izomeraze“ (na primer, fosfoglukomutaza).[1][2][3]

Klasifikacija

EC klasifikacija enzima grupiše izomeraze u klasu: EC 5. One se dele u šest potklasa:

  • EC 5.1 obuhvata enzime koji katalizuju racemizaciju (racemaze) i epimerizaciju (epimeraze)
  • EC 5.2 obuhvata enzime koji katalizuju izomerizaciju geometrijskih izomera (cis-trans izomeraze)
  • EC 5.3 obuhvata intramolekularne oksidoreduktaze
  • EC 5.4 obuhvata intramolekularne transferaze (mutaze)
  • EC 5.5 obuhvata intramolekularne lijaze
  • EC 5.99 obuhvata druge izomeraze (uključujući topoizomeraze)

Reference

  1. ↑ EC 5 Introduction from the Department of Chemistry at Queen Mary, University of London
  2. ↑ Isomerase - Dorland's Medical Dictionary for Health Consumers. 2007. Saunders, an imprint of Elsevier, Inc 6 Nov. 2009
  3. ↑ Isomerase - Webster's New World College Dictionary. LoveToKnow, n.d. Web. 6 November 2009.

Literatura

  • Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
  • Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
  • Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

  • GoPubMed: Top authors, journals, places publishing on Isomerases Arhivirano 2009-02-21 na Wayback Machine-u
  • p
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Proteini: enzimi
TemeTipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6