Metilfenidat
(IUPAC) ime | |||
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metil fenil(piperidin-2-il)acetat | |||
Klinički podaci | |||
Robne marke | Concerta, Methylin, Ritalin, Equasym XL | ||
AHFS/Drugs.com | Monografija | ||
MedlinePlus | a682188 | ||
Identifikatori | |||
CAS broj | 113-45-1 | ||
ATC kod | N06BA04 | ||
PubChem[1][2] | 4158 | ||
DrugBank | DB00422 | ||
ChemSpider[3] | 4015 | ||
UNII | 207ZZ9QZ49 Y | ||
KEGG[4] | D04999 Y | ||
ChEBI | CHEBI:6887 Y | ||
ChEMBL[5] | CHEMBL796 Y | ||
Hemijski podaci | |||
Formula | C14H19NO2 | ||
Mol. masa | 233,30 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Fizički podaci | |||
Tačka topljenja | 214 °C (417 °F) | ||
Farmakokinetički podaci | |||
Bioraspoloživost | ~30% (opseg: 11–52%) | ||
Vezivanje za proteine plazme | 10-33% | ||
Metabolizam | Hepatički (80%) | ||
Poluvreme eliminacije | 3-4 sata (d-enantiomer), 1-3 sata (l-enantiomer) | ||
Izlučivanje | Urin (90%) | ||
Farmakoinformacioni podaci | |||
Licenca | US FDA:link | ||
Trudnoća | B3(AU) C(US) | ||
Pravni status | Droga (S8) (AU) Schedule III (CA) ? (UK) Schedule II (SAD) | ||
Opojna droga | Moderate | ||
Način primene | Oralno, transdermalno |
Metilfenidat (Concerta, Methylin, Ritalin, Equasym XL) je psihostimulišući lek i supstituisani fenetilamin koji je odobren tretman hiperkinetičkog poremećaja (ADHD), posturalnog ortostatskog tahikardnog sindroma i narkolepsije. Originalni patent je posedovalo preduzeće CIBA. FDA je odobrila ovaj lek 1955. za tretiranje hiperaktivnosti. Propisivan je od početka 1960-tih. Nivo proskripcija je znatno porastao tokom 1990-tih kad je ADHD dijagnoza postala šire prihvaćena.[6][7]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ When Was Ritalin Invented?, citing Lawrence Diller: "Running on Ritalin", 1999
- ↑ Lange, K.W. et al.: The history of attention deficit hyperactivity disorder. In: Attention Deficit Hyperactivity Disorders, 2(4):241-55. doi: 10.1007/s12402-010-0045-8.
Literatura
- Gardiner Harris (3. 2. 2012.). „F.D.A. Finds Short Supply of Attention Deficit Drugs”. The New York Times. Arhivirano iz originala na datum 2012-02-03. Pristupljeno 3. 2. 2012. »(Archived by WebCite® at [1])«
- L. Alan Sroufe (28. 1. 2012.). „Ritalin Gone Wrong - Opinion - Children\'s A.D.D.Drugs Don\'t Work Long-Term”. The New York Times. Arhivirano iz originala na datum 2012-02-03. Pristupljeno 3. 2. 2012. »(Archived by WebCite® at [2])«
- {Cite journal|author=Lakhan SE, Hagger-Johnson GE |title=The impact of prescribed psychotropics on youth |journal=Clin Pract Epidemol Ment Health |volume=3 |page=21 |year=2007 |pmid=17949504 |pmc=2100041 |doi=10.1186/1745-0179-3-21 |url=http://www.cpementalhealth.com/content/3/1/21 |issue=1}}
- Drug Enforcement Administration, Greene, S.H., Response to CHADD petition concerning Ritalin, 1995, August 7. Washington, DC: DEA, U.S. Department of Justice.
- New Research Helps Explain Ritalin's Low Abuse Potential When Taken As Prescribed – 09/29/1998 Arhivirano 2010-05-28 na Wayback Machine-u. Nih.gov. Retrieved on 2011-04-30.
- Weinberg WA, Brumback RA (1992). „The myth of attention deficit-hyperactivity disorder: symptoms resulting from multiple causes”. J. Child Neurol. 7 (4): 431–45; discussion 446–61. DOI:10.1177/088307389200700420. PMID 1469255.
- Presenters: Joan Hamburg and Dr. Harold Koplewicz (3. 2. 2012.). "Are we over medicating our kids? Speaking with Dr. Harold Koplewicz of @ChildMindDotOrg". Joan Hamburg Show (Radio). 1:11 into the complete two part show - 2 minutes in. WOR Radio Network. WOR. Archived from the original on 2012-12-03. Retrieved 2014-04-05.
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Spoljašnje veze
Portal Medicina | |
Portal Hemija |
Metilfenidat na Wikimedijinoj ostavi
- Metilfenidat na Projektu Open Directory
- Department of Energy September 29, 1998 press release on Ritalin at Brookhaven National Laboratory
- Erowid methylphenidate vault
- U.S. National Library of Medicine: Drug Information Portal – Methylphenidate
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Morfolini: Fenbutrazat • Morazon • Fendimetrazin • Fenmetrazin; Oksazolini: 4-Metilaminoreks • Aminoreks • Klominoreks • Ciklazodon • Fenozolon • Fluminoreks • Pemolin • Tozalinon; Fenetilamini (takođe amfetamini, katinoni, fentermini, etc): 2-OH-PEA • 4-CAB • 4-FA • 4-FMA • 4-MA • 4-MMA • Alfetamin • Amfehloral • Amfepentoreks • Amfepramon • Amfetamin (Dekstroamfetamin, Levoamfetamin) • Amfetaminil • β-Me-PEA • BDB • Benzfetamin • BOH • Bufedron • Butilon • Katin • Katinon • Hlobenzoreks • Hlortermin • D-Deprenil • Dimetilamfetamin • Dimetilkatinon (Dimetilpropion, metamfepramon) • DMA • DMMA • EBDB • Efedrin • Etkatinon • Etilamfetamin • Etilon • Famprofazon • Fenetilin • Fenproporeks • Flefedron • Fludoreks • Furfenoreks • Hordenin • IAP • IMP • L-Deprenil (Selegilin) • Lisdeksamfetamin • Lofofin • MBDB • MDA (Tenamfetamin) • MDEA • MDMA • MDMPEA • MDOH • MDPEA • Mefenoreks • Mefedron • Mefentermin • Metamfetamin (Dekstrometamfetamin, Levometamftamin) • Metkatinon • Metedron • Metilon • NAP • Ortetamin • Paredrin • pBA • pCA • Pentoreks (Fenpentermin) • Fenetilamin • Foledrin • Fenprometamin • Fentermin • Fenilpropanolamin • pIA • Prenilamin • Propilamfetamin • Pseudoefedrin • Tifloreks • Tiramin • Ksilopropamin • Zilofuramin; Piperazini: 2C-B-BZP • BZP • MBZP • mCPP • MDBZP • MeOPP • pFPP; Drugi: 2-Amino-1,2-dihidronaftalen • 2-Aminoindan • 2-Aminotetralin • 2-Benzilpiperidin • 4-Benzilpiperidin • 5-IAI • Hlofenciklan • Ciklopentamin • Cipenamin • Ciprodenat • Feprosidnin • Gilutensin • Heptaminol • Heksaciklonat • Indanoreks • Izometepten • Metilheksanamin • Oktodrin • Ftalimidopropiofenon • Propilheksedrin (Levopropilheksedrin) • Tuaminoheptan |
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