Lentinan

Lentinan
(IUPAC) ime
β-D-glukopiranozil-(1→6)-[β-D-glukopiranozil-(1→3)-[β-D-glukopiranozil-(1→6)]-β-D-glukopiranozil-(1→3)-β-D-glukopiranozil-(1→3)β-D-glukopiranozil-(1→3)]-β-D-glukopiranoza
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 37339-90-5
ATC kod L03AX01
PubChem[1][2] 37723
KEGG[3] D01695 DaY
Hemijski podaci
Formula C42H72O36 
Mol. masa 1152.99948 g/mol
SMILES eMolekuli & PubHem
InChI
InChI=InChI=1S/C42H72O36/c43-1-8-15(48)22(55)25(58)37(69-8)66-6-13-20(53)32(28(61)36(65)68-13)75-40-29(62)33(18(51)11(4-46)72-40)77-41-30(63)34(19(52)12(5-47)73-41)78-42-31(64)35(76-39-27(60)24(57)17(50)10(3-45)71-39)21(54)14(74-42)7-67-38-26(59)23(56)16(49)9(2-44)70-38/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22+,23+,24+,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36-,37-,38-,39+,40+,41+,42+/m1/s1
Key: MAXBMUKIXLNXGX-DMWITZOWSA-N DaY
Sinonimi (2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2R,3R,4S,5R,6S)-3,5-dihidroksi-2-(hidroksimetil)-6-[(2R,3R,4S,5R,6R)-2,3,5-trihidroksi-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihidroksi-6-(hidroksimetil)oksan-2-il]oksimetil]oksan-4-il]oksioksan-4-il]oksi-3,5-dihidroksi-6-(hidroksimetil)oksan-4-il]oksi-3,5-dihidroksi-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihidroksi-6-(hidroksimetil)oksan-2-il]oksimetil]oksan-4-il]oksi-6-(hidroksimetil)oksan-3,4,5-triol
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Lentinan je beta-glukan sa glikozidnim β-1,3:β-1,6 vezama.[4] On je antitumorni polisaharid iz šitake (Lentinula edodes) pečurke.[4] Lentinan je polisaharid sa molekulskom težinom od oko 500.000 Da. Japanska farmaceutska kompanija Ajinomoto je razvila lek Lentinan, koji se intravenozno dozira kao agens protiv kancera.[5]

Lentinan je jedan od lekova protiv kancera[6] za koji je pokazano da utiče na odbrambeni imunski sistem domaćina.[7]

Klinička israživanja na obolelima od raka su ukazala na vezu između lentinana i povišenog stepena perživljavanja, poboljšanog kvaliteta života, i umanjene ponovne pojave kancera.[8][9][10][11][12][13][14][15]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  4. ↑ 4,0 4,1 Cancer Guide Arhivirano 2012-12-31 na Wayback Machine-u Includes many abstracts
  5. ↑ „Medicinal Mushrooms:Their therapeutic properties and current medicalusage with special emphasis on cancer treatments”. 
  6. ↑ Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K (1999). „A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group.”. Hepatogastroenterology 46 (28): 2662–8. PMID 10522061. 
  7. ↑ Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K (1999). „A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group”. Hepatogastroenterology 46 (28): 2662–8. PMID 10522061. 
  8. ↑ Yang P, Liang M, Zhang Y, Shen B. (Aug 2008). „Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC.”. Adv Ther. 25 (8): 787–94. DOI:10.1007/s12325-008-0079-x. PMID 18670743 
  9. ↑ Nimura H, Mitsumori N, Takahashi N, (Jun 2006). „[S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer]”. Gan to Kagaku Ryoho. 33 (1): 106–9. PMID 16897983 
  10. ↑ Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K. (1999). „A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group.”. Hepatogastroenterology. 46 (28): 2662–8. PMID 10522061 
  11. ↑ Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (July 2009). „Individual Patient Based Meta-analysis of Lentinan for Unresectable/Recurrent Gastric Cancer”. Anticancer Res. 29 (7): 2739–45. PMID 19596954. 
  12. ↑ Hazama S, Watanabe S, Ohashi M, et al. (July 2009). „Efficacy of Orally Administered Superfine Dispersed Lentinan ({beta1,3-Glucan) for the Treatment of Advanced Colorectal Cancer”. Anticancer Res. 29 (7): 2611–7. PMID 19596936. 
  13. ↑ Kataoka H, Shimura T, Mizoshita T, et al. (2009). „Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life”. Hepatogastroenterology 56 (90): 547–50. PMID 19579640. 
  14. ↑ Isoda N, Eguchi Y, Nukaya H, et al. (2009). „Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma”. Hepatogastroenterology 56 (90): 437–41. PMID 19579616. 
  15. ↑ Shimizu K, Watanabe S, Watanabe S, et al. (2009). „Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer”. Hepatogastroenterology 56 (89): 240–4. PMID 19453066. 

Literatura

  • Chihara, G. et al. ”Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom)”, Cancer Research (1970),30(11):2776-2781.
  • Ina, K. et al. “Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy”, World Journal of Clinical Oncology (2011),2(10):339-343.

Vidi još

  • Medicinske pečurke

Spoljašnje veze

  • Lentinan effects (antitumor and others)
  • p
  • r
  • u
Endogeni
G-CSF (Filgrastim/Pegfilgrastim, Lenograstim) • GM-CSF (Molgramostim, Sargramostim) • SCF (Ancestim)
alfa: Interferon alfa prirodni • Interferon alfa-2a/Peginterferon alfa-2a • Interferon alfa-2b/Peginterferon alfa-2b • Interferon alfa-n1 • Interferon alfacon-1

beta: Interferon beta prirodni • Interferon beta-1a • Interferon beta-1b

Interferon-gama
Pegademaza • Imunocianin • Tasonermin • Prolaktin • Hormon rasta
Drugi
Eksogeni
vakcine (BCG vakcina, Melanoma vakcina) • beta-glukan (Lentinan) • Mifamurtid • tiazolidin (Pidotimod) • heterociklična jedinjenja (Plerixafor) • poliribonukleotid (Poliinozinska:policitidinska kiselina) • hidroksikinolin (Rokinimeks) • oligopeptid (Glatiramer acetat, Timopentin)

M: LMC

ćelije/fis/auag/auab

imdf/ipig/hyps/tumr

proc, lek (L3/4)

  • p
  • r
  • u
Opšte:
Geometrija
Monosaharidi
Ketotetroze (Dihidroksiaceton) • Aldotrioze (Gliceraldehid)
Ketopentoze (Eritruloza) • Aldotetroze (Eritroza, Treoza)
>6
Višestruki
Biohemijske familije: Ugljeni hidrati (Glikozidi,Alkoholi) • Lipidi (Steroidi,Fosfolipidi,Glikolipidi,Masne kiseline,Tetrapiroli) • Proteini (Aminokiseline,Peptidi,Glikoproteini) • Nukleobaze/Nukleinske kiseline