N-Arahidonoildopamin
| N-Arahidonoildopamin | |||
|---|---|---|---|
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| IUPAC ime |
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| Drugi nazivi | NADA | ||
| Identifikacija | |||
| CAS registarski broj | 199875-69-9  Y | ||
| PubChem[1][2] | 5282105 | ||
| ChemSpider[3] | 4445314 Y | ||
| ChEMBL[4] | CHEMBL138921 Y | ||
| Jmol-3D slike | Slika 1 | ||
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| Svojstva | |||
| Molekulska formula | C28H41NO3 | ||
| Molarna masa | 439,63 g/mol | ||
| Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
| Infobox references | |||
N-Arahidonoildopamin (NADA) je endokannabinoid koji deluje kao agonist CB1 receptora[5] i TRPV1 jonskog kanala. On je otkriven 2002. Prisutan je u mozgu pacova, sa posebno visokim koncentracijama u hipokampusu, cerebelumu i strijatumu. On aktivira TRPV1 kanal sa EC50 od oko 50 nM.[6]
References
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Ralevic V. (July 2003). „Cannabinoid modulation of peripheral autonomic and sensory neurotransmission.”. European Journal of Pharmacology 472 (1-2): 1–21. DOI:10.1016/S0014-2999(03)01813-2. PMID 12860468.
- ↑ Huang SM, Bisogno T, Trevisani M, et al. (June 2002). „An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors”. Proceedings of the National Academy of Sciences of the United States of America 99 (12): 8400–5. DOI:10.1073/pnas.122196999. PMC 123079. PMID 12060783.
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Spoljašnje veze
 | Portal Hemija |
- General information about NADA.
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8,11-DiOH-THC • 11-COOH-THC • 11-OH-THC
Arahidonoil etanolamid (Anandamid ili AEA) • 2-Arahidonoilglicerol (2-AG) • 2-Arahidonil gliceril etar (noladin etar) • Virodhamin • N--Arahidonoil dopamin (NADA) • Oleamid • RVD-Hpα
agonisti receptora
| Klasični kanabinoidi (Dibenzopirani) | A-40174 • A-41988 • A-42574 • Ajulemska kiselina • AM-087 • AM-411 • AM-855 • AM-905 • AM-906 • AM-919 • AM-926 • AM-938 • AM-2389 • AM-4030 • AMG-1 • AMG-3 • AMG-36 • AMG-41 • Deksanabinol (HU-211) • DMHP • Dronabinol • HHC-{ • HU-210 • JWH-051 • JWH-133 • JWH-139 • JWH-161 • JWH-229 • JWH-359 • KM-233 • L-759,633 • L-759,656 • Levonantradol (CP 50,5561) • Menabitan • Nabazenil • Nabidroks (Kanbisol) • Nabilon • Nabitan • Naboktat • O-224 • O-581 • O-774 • O-806 • O-823 • O-1057 • O-1125 • O-1191 • O-1238 • O-2048 • O-2113 • O-2365 • O-2372 • O-2373 • O-2383 • O-2426 • O-2484 • O-2545 • O-2694 • O-2715 • O-2716 • O-3223 • O-3226 • Paraheksil • Perotetinen • Pirnabin • THC-O-acetat • THC-O-fosfat |
|---|---|
| Neklasični kanabinoidi | |
| Benzoilindoli | 1-Butil-3-(2-metoksibenzoil)indol • 1-Butil-3-(4-metoksibenzoil)indol • 1-Pentil-3-(2-metoksibenzoil)indol • AM-630 • AM-679 • AM-694 • AM-1241 • AM-2233 • GW-405,833 (L-768,242) • Pravadolin • RCS-4 • WIN 54,461 |
| Naftoilindoli | |
| Naftilmetilindoli | JWH-175 • JWH-184 • JWH-185 • JWH-192 • JWH-194 • JWH-195 • JWH-196 • JWH-197 • JWH-199 |
| Fenilacetilindoli | |
| Naftoilpiroli | |
| Eikozanoidi | AM-883 • AM-1346 • Arahidonil-2'-hloroetilamid (ACEA) • Arahidonilciklopropilamid (ACPA) • Metanandamid (AM-356) • O-585 • O-689 • O-1812 • O-1860 • O-1861 |
| Drugi | N-(S)-Fenhil-1-(2-morfolinoetil)-7-metoksindol-3-karboksamid • A-796,260 • A-834,735 • A-836,339 • A-955,840 • Abnormalni kanabidiol • AB-001 • AKB48 • AM-1248 • AZ-11713908 • BAY 38-7271 • BAY 59-3074 • CB-13 • CB-86 • CBS-0550 • GW-842,166X • JWH-176 • JTE 7-31 • LASSBio-881 • LBP-1 • Lilamin • MDA-7 • MDA-19 • NMP-7 • O-889 • O-1269 • O-1270 • O-1399 • O-1918 • O-2220 • Org 28312 • Org 28611 • PF-03550096 • S-444,823 • Tedalinab • UR-144 • URB-447 • SER-601 • VSN-16 • WIN 56,098 • XLR-11 |
kanabinoidnih receptora
pojačivači aktivnosti
AM-404 • Arahidonoil serotonin • Arvanil • Biohanin A • CAY-10401 • CAY-10429 • JNJ 1661010 • JZL184 • JZL195 • Genistein • Kaempferol • LY-2183240 • O-1624 • O-2093 • Oleoiletanolamid (OEA) • Olvanil • Palmitoiletanolamid (PEA) • PF-04457845 • PF-622 • PF-750 • PF-3845 • PHOP • URB-447 • URB-597 • URB-602 • URB-754
kanabinoidnog receptora
AM-251 • AM-281 • AM-630 • AM-1387 • AM-4113 • AM-6527 • AM-6545 • BML-190 • CAY-10508 • CB-25 • CB-52 • CB-86 • CP-945,598 • Drinabant (AVE1625) • Hemopresin • Ibipinabant (SLV319) • JTE-907 • LH-21 • LY-320,135 • MDA-77 • MJ-15 • MK-9470 • NESS-0327 • NIDA-41020 • O-606 • O-1184 • O-1248 • O-2050 • O-2654 • Otenabant • PF-514273 • Rimonabant (SR141716) • Rosonabant (E-6776) • SR144528 • Surinabant (SR147778) • Taranabant (MK-0364) • TM-38837 • VCHSR
