Limfotoksin beta receptor
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| Limfotoksin beta receptor (TNFR superfamilija, član 3) | |||||||||||
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 Kristalografska struktura peptida sa 24 ostatka iz limfotoksin-B receptora vezanog za TRAF3.[1] | |||||||||||
| Dostupne strukture | |||||||||||
| 1RF3 | |||||||||||
| Identifikatori | |||||||||||
| Simboli | LTBR; CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFRSF3 | ||||||||||
| Vanjski ID | OMIM: 600979 MGI: 104875 HomoloGene: 1753 GeneCards: LTBR Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4055 | 17000 | |||||||||
| Ensembl | ENSG00000111321 | n/a | |||||||||
| UniProt | P36941 | n/a | |||||||||
| RefSeq (mRNA) | NM_002342 | XM_982227 | |||||||||
| RefSeq (protein) | NP_002333 | XP_987321 | |||||||||
| Lokacija (UCSC) | Chr 12: 6.36 - 6.37 Mb | n/a | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Limfotoksin beta receptor je receptor za limfotoksin koji je kod ljudi kodiran LTBR genom.[2][3][4]
Funkcija
Protein kodiran ovim genom je član TNF familije receptora. On je izražen na površini većine ćelijskih tipova, uključujući ćelije epitelnog i mijeloidnog porekla, ali ne na T i B limfocitima. Ovaj protein specifično vezuje limfotoksin membransku formu (kompleks limfotoksina-alfa i limftoksina-beta se formira). Limftoksin-beta i njegov ligand učestvuju u razvoju i organizaciji limfoidnog tkiva. Aktivacija ovog proteina može da podstakne apoptozu.[2]
Ne samp da LTBR pomaže u podsticanju apoptoze, on može da dovede do oslobađanja citokina interleukin 8. Prekomerno LTBR izražavanje u HEK293 ćelima povećava IL-8 promotorsku aktivnost, i dovodi do IL-8 oslobađanja. LTBR je takođe esencijalan za razvoj i organizaciju sekundarnih limfoidnih organa i oslobađanje drugih hemokina.[5]
Struktura
Ramačandranov dijagram pokazuje da je 64.6% ostataka u poželjnom regionu.[6] Ova structura je ustanovljena putem difrakcije X-zraka. Njena rezolucija je 3.50 Å. Alfa i beta uglovi su 90 stepeni, dok je gama ugao 120 stepeni.
Interakcije
Za limfotoksin beta receptor je bilo pokazano da interaguje sa Dijablo homologom[7] i TRAF3.[8][9][10]
Reference
- ↑ ’PDB 1RF3; Li C, Norris PS, Ni CZ, Havert ML, Chiong EM, Tran BR, Cabezas E, Reed JC, Satterthwait AC, Ware CF, Ely KR (December 2003). „Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling”. J. Biol. Chem. 278 (50): 50523–9. DOI:10.1074/jbc.M309381200. PMID 14517219.
- ↑ 2,0 2,1 „Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)”.
- ↑ Baens M, Chaffanet M, Cassiman JJ, van den Berghe H, Marynen P (April 1993). „Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid”. Genomics 16 (1): 214–8. DOI:10.1006/geno.1993.1161. PMID 8486360.
- ↑ Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA (April 1994). „A lymphotoxin-beta-specific receptor”. Science (journal) 264 (5159): 707–10. DOI:10.1126/science.8171323. PMID 8171323.
- ↑ Chang YH, Hsieh SL, Chen MC, Lin WW (August 2002). „Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation”. Exp. Cell Res. 278 (2): 166–74. DOI:10.1006/excr.2002.5573. PMID 12169272.
- ↑ „MolProbity Ramachandran analysis”. Arhivirano iz originala na datum 2012-10-12.
- ↑ Kuai, Jun; Nickbarg Elliott, Wooters Joe, Qiu Yongchang, Wang Jack, Lin Lih-Ling (April 2003). „Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis”. J. Biol. Chem. (United States) 278 (16): 14363–9. DOI:10.1074/jbc.M208672200. ISSN 0021-9258. PMID 12571250.
- ↑ VanArsdale, T L; VanArsdale S L, Force W R, Walter B N, Mosialos G, Kieff E, Reed J C, Ware C F (March 1997). „Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (6): 2460–5. DOI:10.1073/pnas.94.6.2460. ISSN 0027-8424. PMC 20110. PMID 9122217.
- ↑ Wu, M Y; Wang P Y, Han S H, Hsieh S L (April 1999). „The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells”. J. Biol. Chem. (UNITED STATES) 274 (17): 11868–73. DOI:10.1074/jbc.274.17.11868. ISSN 0021-9258. PMID 10207006.
- ↑ Marsters, S A; Ayres T M, Skubatch M, Gray C L, Rothe M, Ashkenazi A (May 1997). „Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1”. J. Biol. Chem. (UNITED STATES) 272 (22): 14029–32. DOI:10.1074/jbc.272.22.14029. ISSN 0021-9258. PMID 9162022.
Literatura
- Elewaut D, Ware CF (2007). „The unconventional role of LT alpha beta in T cell differentiation.”. Trends Immunol. 28 (4): 169–75. DOI:10.1016/j.it.2007.02.005. PMID 17336158.
- Browning JL, Ngam-ek A, Lawton P, et al. (1993). „Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.”. Cell 72 (6): 847–56. DOI:10.1016/0092-8674(93)90574-A. PMID 7916655.
- Crowe PD, VanArsdale TL, Walter BN, et al. (1994). „A lymphotoxin-beta-specific receptor.”. Science 264 (5159): 707–10. DOI:10.1126/science.8171323. PMID 8171323.
- Baens M, Chaffanet M, Cassiman JJ, et al. (1993). „Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid.”. Genomics 16 (1): 214–8. DOI:10.1006/geno.1993.1161. PMID 8486360.
- Baens M, Aerssens J, van Zand K, et al. (1996). „Isolation and regional assignment of human chromosome 12p cDNAs.”. Genomics 29 (1): 44–52. DOI:10.1006/geno.1995.1213. PMID 8530100.
- Wang X, Bornslaeger EA, Haub O, et al. (1996). „A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein.”. Dev. Biol. 177 (1): 274–90. DOI:10.1006/dbio.1996.0162. PMID 8660894.
- Nakano H, Oshima H, Chung W, et al. (1996). „TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.”. J. Biol. Chem. 271 (25): 14661–4. DOI:10.1074/jbc.271.25.14661. PMID 8663299.
- Matsumoto M, Hsieh TY, Zhu N, et al. (1997). „Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor.”. J. Virol. 71 (2): 1301–9. PMC 191185. PMID 8995654.
- VanArsdale TL, VanArsdale SL, Force WR, et al. (1997). „Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB.”. Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2460–5. DOI:10.1073/pnas.94.6.2460. PMC 20110. PMID 9122217.
- Wu MY, Hsu TL, Lin WW, et al. (1997). „Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells.”. J. Biol. Chem. 272 (27): 17154–9. DOI:10.1074/jbc.272.27.17154. PMID 9202035.
- Chen CM, You LR, Hwang LH, Lee YH (1997). „Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor.”. J. Virol. 71 (12): 9417–26. PMC 230246. PMID 9371602.
- Mizushima S, Fujita M, Ishida T, et al. (1998). „Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).”. Gene 207 (2): 135–40. DOI:10.1016/S0378-1119(97)00616-1. PMID 9511754.
- Krajewska M, Krajewski S, Zapata JM, et al. (1998). „TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.”. Am. J. Pathol. 152 (6): 1549–61. PMC 1858434. PMID 9626059.
- Boussaud V, Soler P, Moreau J, et al. (1999). „Expression of three members of the TNF-R family of receptors (4-1BB, lymphotoxin-beta receptor, and Fas) in human lung.”. Eur. Respir. J. 12 (4): 926–31. DOI:10.1183/09031936.98.12040926. PMID 9817170.
- Murphy M, Walter BN, Pike-Nobile L, et al. (1999). „Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues.”. Cell Death Differ. 5 (6): 497–505. DOI:10.1038/sj.cdd.4400374. PMID 10200501.
- Wu MY, Wang PY, Han SH, Hsieh SL (1999). „The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells.”. J. Biol. Chem. 274 (17): 11868–73. DOI:10.1074/jbc.274.17.11868. PMID 10207006.
- Yu KY, Kwon B, Ni J, et al. (1999). „A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.”. J. Biol. Chem. 274 (20): 13733–6. DOI:10.1074/jbc.274.20.13733. PMID 10318773.
- Rooney IA, Butrovich KD, Glass AA, et al. (2000). „The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells.”. J. Biol. Chem. 275 (19): 14307–15. DOI:10.1074/jbc.275.19.14307. PMID 10799510.
- Langeggen H, Berge KE, Johnson E, Hetland G (2003). „Human umbilical vein endothelial cells express complement receptor 1 (CD35) and complement receptor 4 (CD11c/CD18) in vitro.”. Inflammation 26 (3): 103–10. DOI:10.1023/A:1015585530204. PMID 12083416.
- Chang YH, Hsieh SL, Chen MC, Lin WW (2002). „Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.”. Exp. Cell Res. 278 (2): 166–74. DOI:10.1006/excr.2002.5573. PMID 12169272.
Spoljašnje veze
- MeSH Lymphotoxin+beta+Receptor
- p
- r
- u
(GPCR)
CC hemokinski receptori | |
|---|---|
CXC hemokinski receptori | IL-8 (CXCR1, CXCR2) • CXCR3 • CXCR4 • CXCR5 • CXCR6 • CXCR7 |
Drugi | CCBP2 • CMKLR1 • CX3CR1 • XCR1 |
1-10 | |
|---|---|
11-20 | TNFRSF10A (CD261) • TNFRSF10B (CD262) • TNFRSF10C (CD263) • TNFRSF10D (CD264) • TNFRSF11A (CD265/RANK) • TNFRSF11B (Osteoprotegerin) • TNFRSF12A (CD266) • TNFRSF13B (CD267) • TNFRSF13C • TNFRSF14 (CD268) • TNFRSF16 (Receptor nervnog faktora rasta) • TNFRSF17 (CD269) • TNFRSF18 • TNFRSF19 |
21-25 | TNFRSF21 • TNFRSF25 • TNFRSF27 |
zajednički beta lanac: Interleukinski receptori (3, 5) • GM-CSF zajednički gama lanac: Interleukinski receptori (2, 4, 7, 9, 13/A1/A2, 15, 21) gp130 koristeći: Interleukinski receptori (6, 27) • Onkostatin M • Leukemija inhibitorni faktor drugi Interleukinski receptori (11/A, 12/B1/B2, 23) drugi CSF receptori (EPO, G-CSF, Trombopoietin) Hormonski receptor: GH • prolaktin | |
Tip II | Interleukini (10, 20, 22, 28) • interferon (-α/β, -γ) |
TGF-beta (1, 2)
IL-17 (IL17RA, IL17RB, IL17RC, IL17RD, IL17RE)
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
