CXCL7

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Pro-trombocit bazični protein (hemokin (C-X-C motiv) ligand 7)

PDB prikaz baziran na 1f9p.
Dostupne strukture
1f9p, 1nap, 1tvx
Identifikatori
SimboliPPBP; PBP; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
Vanjski IDOMIM: 121010 MGI: 1888712 HomoloGene: 48122 GeneCards: PPBP Gene
Ontologija gena
Molekularna funkcija aktivnost glukoznog transmembranskog transportera
hemokinska altivnost
aktivnost faktora rasta
Celularna komponenta ekstracelularni region
ekstracelularni prostor
Biološki proces regulacija progresije kroz ćelijski ciklus
hemotaksa
imunski odgovor
ćelijska proliferacija
glukozni transport
odbrambeni respons na bakterije
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez547357349
EnsemblENSG00000163736ENSMUSG00000029372
UniProtP02775n/a
RefSeq (mRNA)NM_002704NM_023785
RefSeq (protein)NP_002695NP_076274
Lokacija (UCSC)Chr 4:
75.07 - 75.07 Mb
Chr 5:
91.84 - 91.85 Mb
PubMed pretraga[1][2]

CXCL7, hemokin (C-X-C motiv) ligand 7, je ljudski gen[1] koji kodira istoimeni protein. CXCL7 je mali citokin iz CXC hemokin familije. On je izoforma beta-tromboglobulina ili protrombocit bazični protein (PPBP).[2][3]

CXCL7 protein se oslobađa u velikim količinama iz trombocita nakon njihove aktivacije.[4] On stimuliše razne procese uključujući mitogenezu, sintezu ekstracelularnog matriksa, metabolizam glukoze i sintezu plazminogen aktivatora.[5][6]

Reference

  1. „Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)”. 
  2. Hristov M, Zernecke A, Bidzhekov K, et al. (March 2007). „Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury”. Circ. Res. 100 (4): 590–7. DOI:10.1161/01.RES.0000259043.42571.68. PMID 17272812. 
  3. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  4. Majumdar S, Gonder D, Koutsis B, Poncz M (1991). „Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4”. J Biol Chem 266 (9): 5785–9. PMID 1826003. 
  5. Castor C, Miller J, Walz D (1983). „Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor”. Proc Natl Acad Sci USA 80 (3): 765–9. DOI:10.1073/pnas.80.3.765. PMC 393460. PMID 6572368. 
  6. Castor C, Furlong A, Carter-Su C (1985). „Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III”. Biochemistry 24 (7): 1762–7. DOI:10.1021/bi00328a029. PMID 4005226. 

Literatura

  • Begg GS, Pepper DS, Chesterman CN, Morgan FJ (1978). „Complete covalent structure of human beta-thromboglobulin.”. Biochemistry 17 (9): 1739–44. DOI:10.1021/bi00602a024. PMID 77677. 
  • Kaplan KL, Broekman MJ, Chernoff A, et al. (1979). „Platelet alpha-granule proteins: studies on release and subcellular localization.”. Blood 53 (4): 604–18. PMID 426909. 
  • Tunnacliffe A, Majumdar S, Yan B, Poncz M (1992). „Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4.”. Blood 79 (11): 2896–900. PMID 1316786. 
  • Cohen AB, Stevens MD, Miller EJ, et al. (1992). „Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets.”. Am. J. Physiol. 263 (2 Pt 1): L249–56. PMID 1387511. 
  • Morris SW, Nelson N, Valentine MB, et al. (1992). „Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.”. Genomics 14 (3): 685–91. DOI:10.1016/S0888-7543(05)80169-7. PMID 1427896. 
  • Majumdar S, Gonder D, Koutsis B, Poncz M (1991). „Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4.”. J. Biol. Chem. 266 (9): 5785–9. PMID 1826003. 
  • Wenger RH, Hameister H, Clemetson KJ (1991). „Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily.”. Hum. Genet. 87 (3): 367–8. DOI:10.1007/BF00200921. PMID 1830861. 
  • Hjemdahl P, Perneby C, Theodorsson E, et al. (1992). „A new assay for beta-thromboglobulin in urine.”. Thromb. Res. 64 (1): 33–43. DOI:10.1016/0049-3848(91)90203-9. PMID 1837963. 
  • Brandt E, Van Damme J, Flad HD (1991). „Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III.”. Cytokine 3 (4): 311–21. DOI:10.1016/1043-4666(91)90499-4. PMID 1873479. 
  • Clark-Lewis I, Moser B, Walz A, et al. (1991). „Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide.”. Biochemistry 30 (12): 3128–35. DOI:10.1021/bi00226a021. PMID 2007144. 
  • Walz A, Baggiolini M (1990). „Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.”. J. Exp. Med. 171 (2): 449–54. DOI:10.1084/jem.171.2.449. PMC 2187709. PMID 2406364. 
  • Holt JC, Harris ME, Holt AM, et al. (1986). „Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.”. Biochemistry 25 (8): 1988–96. DOI:10.1021/bi00356a023. PMID 2423119. 
  • Walz A, Baggiolini M (1989). „A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils.”. Biochem. Biophys. Res. Commun. 159 (3): 969–75. DOI:10.1016/0006-291X(89)92203-1. PMID 2522778. 
  • Wenger RH, Wicki AN, Walz A, et al. (1989). „Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.”. Blood 73 (6): 1498–503. PMID 2713489. 
  • Castor CW, Walz DA, Ragsdale CG, et al. (1989). „Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets.”. Biochem. Biophys. Res. Commun. 163 (2): 1071–8. DOI:10.1016/0006-291X(89)92330-9. PMID 2783111. 
  • Holt JC, Rabellino EM, Gewirtz AM, et al. (1988). „Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human platelets and megakaryocytes.”. Exp. Hematol. 16 (4): 302–6. PMID 2966071. 
  • Castor CW, Furlong AM, Carter-Su C (1985). „Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III.”. Biochemistry 24 (7): 1762–7. DOI:10.1021/bi00328a029. PMID 4005226. 
  • McLaren KM, Pepper DS (1983). „Immunological localisation of beta-thromboglobulin and platelet factor 4 in human megakaryocytes and platelets.”. J. Clin. Pathol. 35 (11): 1227–31. DOI:10.1136/jcp.35.11.1227. PMC 497932. PMID 6183294. 
  • Castor CW, Miller JW, Walz DA (1983). „Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.”. Proc. Natl. Acad. Sci. U.S.A. 80 (3): 765–9. DOI:10.1073/pnas.80.3.765. PMC 393460. PMID 6572368. 
  • Malkowski MG, Wu JY, Lazar JB, et al. (1995). „The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution.”. J. Biol. Chem. 270 (13): 7077–87. DOI:10.1074/jbc.270.13.7077. PMID 7706245. 

Spoljašnje veze

  • MeSH Platelet+factor+7
  • p
  • r
  • u
PDB Galerija
1f9p: Kristalna struktura aktivirajućeg peptida-III (CTAP-III) iz veznog tkiva u kompleksu sa polivinil sumpornom kiselinom
1f9p: Kristalna struktura aktivirajućeg peptida-III (CTAP-III) iz veznog tkiva u kompleksu sa polivinil sumpornom kiselinom  
1nap: Kristalna struktura rekombinantnog ljudskog neutrofil-aktivirajućeg peptida-2 (M6L) u 1.9 Å rezoluciji
1nap: Kristalna struktura rekombinantnog ljudskog neutrofil-aktivirajućeg peptida-2 (M6L) u 1.9 Å rezoluciji  
1tvx: Varijanta neutrofil-aktivirajućeg peptida-2 iz M6L sa pet dodatnih amino terminal ostataka (DSDLY)
1tvx: Varijanta neutrofil-aktivirajućeg peptida-2 iz M6L sa pet dodatnih amino terminal ostataka (DSDLY)  
  • p
  • r
  • u
Po familiji
IL-1 superfamilija
1 (1Ra) • 18 • 33
poput IL-6/gp130 koristeći
IL-10 familija
10 • 19 • 20 • 22 • 24 • 26
28 • 29
2/15 • 3 • 4 • 7 • 9 • 13 • 21
IL-12 familija
12 (B) • 23 • 27 • 35
Drugi
5 • 8 • 14 • 16 • 17/25 (A) • 32  • 34
CCL
1 • 2 • 3 • 4 • 5 • 6 • 7 • 8 • 9 • 10 • 11 • 12 • 13 • 14 • 15 • 16 • 17 • 18 • 19 • 20 • 21 • 22 • 23 • 24 • 25 • 26 • 27 • 28
CXCL
1 • 2 • 3 • 4 • 5 • 6 • 7 • 8 • 9 • 10 • 11 • 12 • 13 • 14 • 15 • 16 • 17
CX3CL
XCL
1 • 2
Glavni
TNF (ligand) superfamilija
CD70 • CD153 • CD154
alfa ( Pegilirani 2a, Pegilirani 2b), beta (1a, 1b)
Drugi
Po funkciji
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)