ELF1

Protein-coding gene in the species Homo sapiens
ELF1
Identifiers
AliasesELF1, E74 like ETS transcription factor 1, EFTUD1, RIA1
External IDsOMIM: 189973; MGI: 107180; HomoloGene: 7303; GeneCards: ELF1; OMA:ELF1 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for ELF1
Genomic location for ELF1
Band13q14.11Start40,931,924 bp[1]
End41,061,440 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for ELF1
Genomic location for ELF1
Band14|14 D3Start79,718,634 bp[2]
End79,819,934 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • monocyte

  • lymph node

  • bone marrow cells

  • Achilles tendon

  • nipple

  • appendix

  • gallbladder

  • mucosa of pharynx

  • urethra
Top expressed in
  • mesenteric lymph nodes

  • decidua

  • thymus

  • mucosa of urinary bladder

  • transitional epithelium of urinary bladder

  • blood

  • left colon

  • spleen

  • lumbar spinal ganglion

  • left lung lobe
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA binding
  • sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • regulation of cytokine production
  • positive regulation of transcription, DNA-templated
  • cell differentiation
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • negative regulation of T cell receptor signaling pathway
  • transcription by RNA polymerase II
  • regulation of cytokine-mediated signaling pathway
  • regulation of B cell receptor signaling pathway
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1997

13709

Ensembl

ENSG00000120690

ENSMUSG00000036461

UniProt

P32519

Q60775

RefSeq (mRNA)
NM_001145353
NM_172373
NM_001370329
NM_001370330
NM_001370331

NM_001370332

NM_001286411
NM_001286412
NM_007920

RefSeq (protein)
NP_001138825
NP_758961
NP_001357258
NP_001357259
NP_001357260

NP_001357261

NP_001273340
NP_001273341
NP_031946

Location (UCSC)Chr 13: 40.93 – 41.06 MbChr 14: 79.72 – 79.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene.[5]

Function

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and can act as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120690 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036461 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: E74-like factor 1 (ets domain transcription factor)".

Further reading

  • Xiang P, Lo C, Argiropoulos B, Lai CB, Rouhi A, Imren S, Jiang X, Mager D, Humphries RK (Sep 2010). "Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1". Experimental Hematology. 38 (9): 798–8, 808.e1-2. doi:10.1016/j.exphem.2010.06.006. PMC 3887005. PMID 20600580.
  • Juang YT, Solomou EE, Rellahan B, Tsokos GC (Mar 2002). "Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain". Journal of Immunology. 168 (6): 2865–71. doi:10.4049/jimmunol.168.6.2865. PMID 11884456.
  • Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD (May 1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Molecular and Cellular Biology. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
  • Nishiyama C, Takahashi K, Nishiyama M, Okumura K, Ra C, Ohtake Y, Yokota T (Dec 2000). "Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1". Bioscience, Biotechnology, and Biochemistry. 64 (12): 2601–7. doi:10.1271/bbb.64.2601. PMID 11210123.
  • Thompson CB, Wang CY, Ho IC, Bohjanen PR, Petryniak B, June CH, Miesfeldt S, Zhang L, Nabel GJ, Karpinski B (Mar 1992). "cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1". Molecular and Cellular Biology. 12 (3): 1043–53. doi:10.1128/mcb.12.3.1043. PMC 369536. PMID 1545787.
  • Tsokos GC, Nambiar MP, Juang YT (Apr 2003). "Activation of the Ets transcription factor Elf-1 requires phosphorylation and glycosylation: defective expression of activated Elf-1 is involved in the decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus". Annals of the New York Academy of Sciences. 987: 240–5. doi:10.1111/j.1749-6632.2003.tb06054.x. PMID 12727645. S2CID 42190457.
  • Gunther M, Laithier M, Brison O (Jul 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Molecular and Cellular Biochemistry. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. S2CID 1339642.
  • Yang W, Tang H, Zhang Y, Tang X, Zhang J, Sun L, et al. (Jan 2013). "Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians". American Journal of Human Genetics. 92 (1): 41–51. doi:10.1016/j.ajhg.2012.11.018. PMC 3542470. PMID 23273568.
  • Bassuk AG, Anandappa RT, Leiden JM (May 1997). "Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells". Journal of Virology. 71 (5): 3563–73. doi:10.1128/JVI.71.5.3563-3573.1997. PMC 191503. PMID 9094628.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
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  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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