ID1

ID1
Identifiers
Aliases	ID1, ID, bHLHb24, inhibitor of DNA binding 1, HLH protein
External IDs	OMIM: 600349; MGI: 96396; HomoloGene: 1631; GeneCards: ID1; OMA:ID1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.21 Start 31,605,283 bp[1] End 31,606,515 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H1|2 75.41 cM Start 152,578,171 bp[2] End 152,579,330 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula right lung right lobe of thyroid gland olfactory zone of nasal mucosa left lobe of thyroid gland left uterine tube tail of epididymis mucosa of transverse colon gastric mucosa apex of heart Top expressed in mucous cell of stomach epithelium of stomach optic nerve maxillary prominence choroid plexus of fourth ventricle hand molar mandibular prominence pyloric antrum right lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein dimerization activity DNA-binding transcription factor activity protein self-association protein C-terminus binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor binding protein N-terminus binding proteasome binding Cellular component cytoplasm centrosome Golgi apparatus nucleoplasm nucleus Biological process cell-abiotic substrate adhesion cellular response to transforming growth factor beta stimulus cellular response to nerve growth factor stimulus cellular response to peptide regulation of transcription, DNA-templated regulation of MAPK cascade blood vessel morphogenesis lung morphogenesis response to organic cyclic compound blood vessel endothelial cell migration positive regulation of epithelial cell proliferation rhythmic process cellular response to dopamine response to antibiotic negative regulation of DNA binding endothelial cell morphogenesis collagen metabolic process negative regulation of apoptotic process negative regulation of endothelial cell differentiation negative regulation of transcription by RNA polymerase II regulation of angiogenesis negative regulation of protein binding BMP signaling pathway negative regulation of DNA-binding transcription factor activity transcription, DNA-templated negative regulation of osteoblast differentiation negative regulation of gene expression cellular response to epidermal growth factor stimulus multicellular organism development heart development brain development positive regulation of gene expression regulation of vasculature development negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding negative regulation of dendrite morphogenesis circadian rhythm protein destabilization angiogenesis neuron differentiation negative regulation of protein homodimerization activity positive regulation of actin filament bundle assembly negative regulation of transcription by transcription factor localization lung vasculature development negative regulation of transcription, DNA-templated transforming growth factor beta receptor signaling pathway negative regulation of neuron differentiation regulation of cell cycle negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3397 15901 Ensembl ENSG00000125968 ENSMUSG00000042745 UniProt P41134 P20067 Q6GTZ3 RefSeq (mRNA) NM_181353 NM_002165 NM_010495 NM_001355113 NM_001369018 RefSeq (protein) NP_002156 NP_851998 NP_034625 NP_001342042 NP_001355947 Location (UCSC) Chr 20: 31.61 – 31.61 Mb Chr 2: 152.58 – 152.58 Mb PubMed search [3] [4]
Wikidata
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DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.^[5][6]

Function

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors.^[5] The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts.^[5] This protein may play a role in cell growth, senescence, and differentiation.^[7][8][9] Two transcript variants encoding different isoforms have been found for this gene.^[10]

Interactions

ID1 has been shown to interact weakly with MyoD^{[5][11][12][13][14][15][16]} but very tightly with ubiquitously expressed E proteins.^[17] E proteins heterodimerize with tissue restricted bHLH proteins such as Myod, NeuroD, etc. to form active transcription complexes so by sequestering E proteins, Id proteins can inhibit tissue restricted gene expression in multiple cell lineages using the same biochemical mechanism. Other interacting partners include CASK.^[18]

Clinical significance

ID1 can be used to mark endothelial progenitor cells which are critical to tumor growth and angiogenesis.^[19][20] Targeting ID1 results in decreased tumor growth.^[21][22] ID1 has been shown to be targeted by cannabidiol in certain gliomas and breast cancers.^[23][24]

See also

• Inhibitor of DNA-binding protein

References

Further reading

External links

• ID1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P20067 (Mouse DNA-binding protein inhibitor ID-1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.