| SIX4 |
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| Identifiers |
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| Aliases | SIX4, AREC3, SIX homeobox 4 |
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| External IDs | OMIM: 606342; MGI: 106034; HomoloGene: 69089; GeneCards: SIX4; OMA:SIX4 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 14 (human)[1] |
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| | Band | 14q23.1 | Start | 60,709,539 bp[1] |
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| End | 60,724,351 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 12 (mouse)[2] |
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| | Band | 12|12 C3 | Start | 73,146,383 bp[2] |
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| End | 73,160,230 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - bronchial epithelial cell
- vastus lateralis muscle
- Skeletal muscle tissue of biceps brachii
- Skeletal muscle tissue of rectus abdominis
- deltoid muscle
- nasal epithelium
- mucosa of paranasal sinus
- cartilage tissue
- parotid gland
- epithelium of nasopharynx
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| | Top expressed in | - lumbar spinal ganglion
- intercostal muscle
- maxillary prominence
- parotid gland
- utricle
- foot
- soleus muscle
- digastric muscle
- mandibular prominence
- lobe of prostate
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - sequence-specific DNA binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- DNA-binding transcription factor activity
- DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- transcription cis-regulatory region binding
| | Cellular component | - cytoplasm
- nucleus
- transcription regulator complex
| | Biological process | - tongue development
- trigeminal ganglion development
- sarcomere organization
- generation of neurons
- regulation of branch elongation involved in ureteric bud branching
- negative regulation of apoptotic process
- positive regulation of branching involved in ureteric bud morphogenesis
- transcription, DNA-templated
- multicellular organism development
- negative regulation of satellite cell differentiation
- pharyngeal system development
- anatomical structure morphogenesis
- embryonic skeletal system morphogenesis
- inner ear morphogenesis
- myotome development
- fungiform papilla morphogenesis
- skeletal muscle fiber differentiation
- positive regulation of ureteric bud formation
- regulation of gene expression
- embryonic cranial skeleton morphogenesis
- anatomical structure development
- regulation of synaptic assembly at neuromuscular junction
- olfactory placode formation
- myoblast migration
- thymus development
- positive regulation of transcription, DNA-templated
- regulation of epithelial cell proliferation
- metanephric mesenchyme development
- male sex determination
- skeletal muscle tissue development
- negative regulation of neuron apoptotic process
- regulation of protein localization
- male sex differentiation
- regulation of transcription, DNA-templated
- positive regulation of transcription by RNA polymerase II
- transcription by RNA polymerase II
- male gonad development
- negative regulation of transcription, DNA-templated
- protein localization to nucleus
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 14: 60.71 – 60.72 Mb | Chr 12: 73.15 – 73.16 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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