Sekretin

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Sekretin

Identifikatori

SCT

Vanjski ID

OMIM: 182099 MGI: 99466 HomoloGene: 7928 GeneCards: SCT Gene

Ontologija gena
Molekulska funkcija	• hormonska aktivnost
Ćelijska komponenta	• ekstracelularni region
Biološki proces	• signalni put G-protein spregnutog receptora • sekrecija pankreasnog soka

Ortolozi

Vrsta

Čovek

Miš

Entrez

6343

20287

Ensembl

ENSG00000070031

ENSMUSG00000038580

UniProt

P09683

Q08535

Ref. Sekv. (iRNK)

NM_021920

NM_011328

Ref. Sekv. (protein)

NP_068739

NP_035458

Lokacija (UCSC)

Chr 11:
0.62 - 0.62 Mb

Chr 7:
148.46 - 148.47 Mb

PubMed pretraga

[1]

[2]

Sekretin
Identifikatori
Simbol	SCT
Entrez	6343
HUGO	10607
OMIM	182099
RefSeq	NM_021920
UniProt	P09683
Drugi podaci
Lokus	Hromozom 11 p15.5

Sekretin je hormon digestivnog sistema koji luče S ćelije dvanaestopalačnog creva, stimuliše sekreciju tečnosti bogatih bikarbonatima iz pankreasa i jetre.^[1]^[2]

Reference

↑ Häcki WH (September 1980). „Secretin”. Clin Gastroenterol 9 (3): 609–32. PMID 7000396.
↑ Whitmore TE, Holloway JL, Lofton-Day CE, Maurer MF, Chen L, Quinton TJ, Vincent JB, Scherer SW, Lok S (2000). „Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA”. Cytogenet. Cell Genet. 90 (1-2): 47–52. DOI:10.1159/000015658. PMID 11060443.

Literatura

Saus E, Brunet A, Armengol L, et al. (2010). „Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.”. Journal of psychiatric research 44 (14): HASH(0x117c470). DOI:10.1016/j.jpsychires.2010.03.007. PMID 20398908.
Bertenshaw GP, Turk BE, Hubbard SJ, et al. (2001). „Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.”. J. Biol. Chem. 276 (16): 13248–55. DOI:10.1074/jbc.M011414200. PMID 11278902.
Lee LT, Lam IP, Chow BK (2008). „A functional variable number of tandem repeats is located at the 5' flanking region of the human secretin gene plays a downregulatory role in expression.”. J. Mol. Neurosci. 36 (1-3): 125–31. DOI:10.1007/s12031-008-9083-5. PMID 18566919.
Nussdorfer GG, BahÃ§elioglu M, Neri G, Malendowicz LK (2000). „Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus- pituitary-adrenal axis.”. Peptides 21 (2): 309–24. DOI:10.1016/S0196-9781(99)00193-X. PMID 10764961.
Lossi L, Bottarelli L, Candusso ME, et al. (2004). „Transient expression of secretin in serotoninergic neurons of mouse brain during development.”. Eur. J. Neurosci. 20 (12): 3259–69. DOI:10.1111/j.1460-9568.2004.03816.x. PMID 15610158.
Lee SM, Yung WH, Chen L, Chow BK (2005). „Expression and spatial distribution of secretin and secretin receptor in human cerebellum.”. Neuroreport 16 (3): 219–22. DOI:10.1097/00001756-200502280-00003. PMID 15706223.
Lam IP, Lee LT, Choi HS, et al. (2009). „Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP).”. Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1): G90–7. DOI:10.1152/ajpgi.00094.2009. PMC 2711755. PMID 19372104.
Yamagata T, Aradhya S, Mori M, et al. (2002). „The human secretin gene: fine structure in 11p15.5 and sequence variation in patients with autism.”. Genomics 80 (2): 185–94. DOI:10.1006/geno.2002.6814. PMID 12160732.
Lee LT, Tan-Un KC, Chow BK (2006). „Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1.”. Ann. N. Y. Acad. Sci. 1070: 393–8. DOI:10.1196/annals.1317.051. PMID 16888198.
Onori P, Wise C, Gaudio E, et al. (2010). „Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor.”. Int. J. Cancer 127 (1): 43–54. DOI:10.1002/ijc.25028. PMID 19904746.
Lee LT, Tan-Un KC, Pang RT, et al. (2004). „Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.”. Mol. Endocrinol. 18 (7): 1740–55. DOI:10.1210/me.2003-0461. PMID 15118068.
Lu Y, Owyang C (2009). „Secretin-induced gastric relaxation is mediated by vasoactive intestinal polypeptide and prostaglandin pathways.”. Neurogastroenterol. Motil. 21 (7): 754-e47. DOI:10.1111/j.1365-2982.2009.01271.x. PMC 2743409. PMID 19239625.
Gandhi S, Rubinstein I, Tsueshita T, Onyuksel H (2002). „Secretin self-assembles and interacts spontaneously with phospholipids in vitro.”. Peptides 23 (1): 201–4. DOI:10.1016/S0196-9781(01)00596-4. PMID 11814635.
Love JW (2008). „Peptic ulceration may be a hormonal deficiency disease.”. Med. Hypotheses 70 (6): 1103–7. DOI:10.1016/j.mehy.2007.12.011. PMID 18280672.
Lam IP, Lee LT, Choi HS, Chow BK (2006). „Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells.”. Ann. N. Y. Acad. Sci. 1070: 371–5. DOI:10.1196/annals.1317.047. PMID 16888194.
Luttrell LM (2008). „Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.”. Mol. Biotechnol. 39 (3): 239–64. DOI:10.1007/s12033-008-9031-1. PMID 18240029.
Du K, Couvineau A, Rouyer-Fessard C, et al. (2002). „Human VPAC1 receptor selectivity filter. Identification of a critical domain for restricting secretin binding.”. J. Biol. Chem. 277 (40): 37016–22. DOI:10.1074/jbc.M203049200. PMID 12133828.
Portela-Gomes GM, Johansson H, Olding L, Grimelius L (1999). „Co-localization of neuroendocrine hormones in the human fetal pancreas.”. Eur. J. Endocrinol. 141 (5): 526–33. DOI:10.1530/eje.0.1410526. PMID 10576771.
Mutoh H, Ratineau C, Ray S, Leiter AB (2000). „Review article: transcriptional events controlling the terminal differentiation of intestinal endocrine cells.”. Aliment. Pharmacol. Ther. 14 Suppl 1: 170–5. PMID 10807420.

Endokrini sistem: hormoni (Peptidni hormoni • Steroidni hormoni)

Endokrine
žlezde

Hipotalamusno-
hipofizni

Hipotalamus	GnRH • TRH • Dopamin • CRH • GHRH/Somatostatin • Melanin-koncentrirajući hormon
Posteriorno hipofizni	Vazopresin • Oksitocin
Anteriorno hipfizni	α (FSH FSHB, LH LHB, TSH TSHB, CGA) • Prolaktin • POMC (CLIP, ACTH, MSH, Endorfini, Lipotropin) • GH