Kasinin

Kasinin
Drugi nazivi L-alfa-aspartil-L-valil-L-prolil-L-lizil-L-seril-L-alfa-aspartil-L-glutaminil-L-fenilalanil-L-valilglicil-L-leucil-L-metioninamid
Identifikacija
CAS registarski broj 63968-82-1 DaY
PubChem[1][2] 45749
MeSH Kassinin
ChEMBL[3] CHEMBL425809 DaY
Jmol-3D slike Slika 1
SMILES

CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C(CC(=O)O)N

InChI

InChI=1S/C59H95N15O18S/c1-30(2)24-38(53(86)66-35(49(63)82)20-23-93-7)65-44(77)28-64-58(91)47(31(3)4)72-55(88)39(25-33-14-9-8-10-15-33)69-52(85)37(18-19-43(62)76)67-54(87)40(27-46(80)81)70-56(89)41(29-75)71-51(84)36(16-11-12-21-60)68-57(90)42-17-13-22-74(42)59(92)48(32(5)6)73-50(83)34(61)26-45(78)79/h8-10,14-15,30-32,34-42,47-48,75H,11-13,16-29,60-61H2,1-7H3,(H2,62,76)(H2,63,82)(H,64,91)(H,65,77)(H,66,86)(H,67,87)(H,68,90)(H,69,85)(H,70,89)(H,71,84)(H,72,88)(H,73,83)(H,78,79)(H,80,81) DaY
Kod: NXTPETCPVNEEOP-UHFFFAOYSA-N DaY

Svojstva
Molekulska formula C59H95N15O18S
Molarna masa 1334.54

 DaY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Kasinin je peptid dobijen iz Kassina žaba.[4] Kasinin stimuliše sekreciju insulina i glukagona.[5] Po tome se razlikuje od supstance P, sa kojom je strukturno sličan.

Literatura

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  4. ↑ Anastasi A., Montecucchi P.C., Erspamer V., Visser J. (1977). „Amino acid composition and sequence of kassinin, a tachykinin dodecapeptide from the skin of the African frog Kassina senegalensis”. Experientia 33: 857-858. PMID 891753. 
  5. ↑ Hans-Georg Gullner, Haruaki Yajima, Virginia Harris, Roger H. Unger. „Kassinin: Stimulation of Insulin and Glucagon Secretion in the Rat”. Endocrinology 110: 1246-1248. DOI:10.1210/endo-110-4-1246. Arhivirano iz originala na datum 2008-09-05. Pristupljeno 2014-04-11. 

Spoljašnje veze

Portal Hemija
  • p
  • r
  • u
Hormoni
vidi hormoni
Opioidni peptidi
Drugi
Drugi neuropeptidi
Kinini
Neuromedini
B • N • S • U
Drugi
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)