TSPAN13

Protein-coding gene in humans
TSPAN13
Identifiers
AliasesTSPAN13, NET-6, NET6, TM4SF13, tetraspanin 13
External IDsOMIM: 613139; MGI: 1913359; HomoloGene: 8671; GeneCards: TSPAN13; OMA:TSPAN13 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for TSPAN13
Genomic location for TSPAN13
Band7p21.1Start16,753,755 bp[1]
End16,784,536 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for TSPAN13
Genomic location for TSPAN13
Band12|12 A3Start36,064,556 bp[2]
End36,092,499 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • visceral pleura

  • jejunal mucosa

  • endothelial cell

  • mucosa of sigmoid colon

  • Brodmann area 23

  • lower lobe of lung

  • germinal epithelium

  • bronchial epithelial cell

  • middle temporal gyrus
Top expressed in
  • habenula

  • lacrimal gland

  • subiculum

  • utricle

  • transitional epithelium of urinary bladder

  • crypt of lieberkuhn of small intestine

  • salivary gland

  • parotid gland

  • olfactory tubercle

  • right lung
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium channel regulator activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • integral component of plasma membrane
  • membrane
Biological process
  • cell surface receptor signaling pathway
  • regulation of calcium ion transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27075

66109

Ensembl

ENSG00000106537

ENSMUSG00000020577

UniProt

O95857

Q9D8C2

RefSeq (mRNA)

NM_014399

NM_025359

RefSeq (protein)

NP_055214

NP_079635

Location (UCSC)Chr 7: 16.75 – 16.78 MbChr 12: 36.06 – 36.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetraspanin-13 is a protein that in humans is encoded by the TSPAN13 gene.[5]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106537 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020577 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TSPAN13 tetraspanin 13".

Further reading

  • Böhme E, Graf H, Schultz G (1978). "Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP formation in smooth muscle and platelets". Advances in Cyclic Nucleotide Research. 9: 131–43. PMID 27075.
  • Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Serru V, Dessen P, Boucheix C, Rubinstein E (2000). "Sequence and expression of seven new tetraspans". Biochim. Biophys. Acta. 1478 (1): 159–63. doi:10.1016/S0167-4838(00)00022-4. PMID 10719184.
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Huang H, Groth J, Sossey-Alaoui K, et al. (2005). "Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors". Clin. Cancer Res. 11 (12): 4357–64. doi:10.1158/1078-0432.CCR-04-2107. PMID 15958618.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Moroz MA, Serganova I, Zanzonico P, et al. (2007). "Imaging hNET reporter gene expression with 124I-MIBG". J. Nucl. Med. 48 (5): 827–36. doi:10.2967/jnumed.106.037812. PMID 17475971.
  • v
  • t
  • e
ArrestinMembrane-spanning 4A
  • MS4A1
  • MS4A2
  • MS4A3
  • MS4A4A
  • MS4A4E
  • MS4A5
  • MS4A6A
  • MS4A6E
  • MS4A7
  • MS4A8B
  • MS4A9
  • MS4A10
  • MS4A12
  • MS4A13
  • MS4A14
  • MS4A15
  • MS4A18
MyelinPulmonary surfactantTetraspanin
Other/ungrouped
see also other cell membrane protein disorders


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