MS4A7

Protein-coding gene in the species Homo sapiens

MS4A7

Identifiers

Aliases

MS4A7, 4SPAN2, CD20L4, CFFM4, MS4A8, membrane spanning 4-domains A7

External IDs

OMIM: 606502; MGI: 1918846; HomoloGene: 10922; GeneCards: MS4A7; OMA:MS4A7 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q12.2	Start	60,378,485 bp^[1]
Band	11q12.2	End	60,395,951 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	11,298,403 bp^[2]
Band	19\|19 A	End	11,313,510 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

monocyte

spleen

gallbladder

appendix

upper lobe of left lung

granulocyte

right lung

rectum

trabecular bone

lower lobe of lung

Top expressed in

stroma of bone marrow

interventricular septum

calvaria

internal carotid artery

cervix

external carotid artery

mesenteric lymph nodes

vestibular sensory epithelium

thymus

spleen

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


58475


109225

Ensembl


ENSG00000166927


ENSMUSG00000024672

UniProt


Q9GZW8


n/a

RefSeq (mRNA)


NM_206940 NM_021201 NM_206938 NM_206939


NM_001025610 NM_001276398 NM_027836

RefSeq (protein)


NP_067024 NP_996821 NP_996822 NP_996823


n/a

Location (UCSC)

Chr 11: 60.38 – 60.4 Mb

Chr 19: 11.3 – 11.31 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Membrane-spanning 4-domains subfamily A member 7 is a protein that in humans is encoded by the MS4A7 gene.^[5]^[6]^[7]

This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166927 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024672 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishibashi K, Suzuki M, Sasaki S, Imai M (Mar 2001). "Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor". Gene. 264 (1): 87–93. doi:10.1016/S0378-1119(00)00598-9. PMID 11245982.
^ Liang Y, Tedder TF (Jun 2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse". Genomics. 72 (2): 119–27. doi:10.1006/geno.2000.6472. PMID 11401424.
^ ^a ^b "Entrez Gene: MS4A7 membrane-spanning 4-domains, subfamily A, member 7".

Liang Y, Buckley TR, Tu L, et al. (2001). "Structural organization of the human MS4A gene cluster on Chromosome 11q12". Immunogenetics. 53 (5): 357–68. doi:10.1007/s002510100339. PMID 11486273. S2CID 21846867.
Gingras MC, Lapillonne H, Margolin JF (2001). "CFFM4: a new member of the CD20/FcepsilonRIbeta family". Immunogenetics. 53 (6): 468–76. doi:10.1007/s002510100345. PMID 11685457. S2CID 29981957.
Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. Bibcode:2001PNAS...9815089X. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.