Sofalcone

Chemical compound

none

Legal statusLegal status

In general: ℞ (Prescription only)

Identifiers

IUPAC name

[5-[(3-Methylbut-2-en-1-yl)oxy]-2-((2E)-3-{4-[(3-methylbut-2-en-1-yl)oxy]phenyl}prop-2-enoyl)phenoxy]acetic acid

CAS Number

153175-87-2^Y

PubChem CID

5282219

ChemSpider

4445402^N

UNII

2B668TJX8E

KEGG

D01956^Y

ChEBI

CHEBI:135732

CompTox Dashboard (EPA)

DTXSID50860797 DTXSID5023586, DTXSID50860797

Chemical and physical dataFormulaC₂₇H₃₀O₆Molar mass450.531 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

CC(=CCOC1=CC=C(C=C1)C=CC(=O)C2=C(C=C(C=C2)OCC=C(C)C)OCC(=O)O)C

InChI

InChI=1S/C27H30O6/c1-19(2)13-15-31-22-8-5-21(6-9-22)7-12-25(28)24-11-10-23(32-16-14-20(3)4)17-26(24)33-18-27(29)30/h5-14,17H,15-16,18H2,1-4H3,(H,29,30)/b12-7+^N
Key:GFWRVVCDTLRWPK-KPKJPENVSA-N^N

^NY (what is this?) (verify)

Sofalcone (INN) is an oral gastrointestinal medication used in Japan.^[1] It is a synthetic analog of sophoradin,^[2] a type of natural phenol found in Sophora tonkinensis, an herb used in traditional Chinese medicine.

References

^ "Sofalcone". drugs.com.
^ Konturek SJ, Mrzozowski T, Drozdowicz D, Pawlik W, Sendur R (August 1987). "Gastroprotective and ulcer healing effects of solon, a synthetic flavonoid derivative of sophoradin". Hepatogastroenterology. 34 (4): 164–70. PMID 3478294.

Drugs for peptic ulcer and GERD/GORD (A02B)

H₂ antagonists ("-tidine")

Prostaglandins (E)/
analogues ("-prost-")

Proton-pump inhibitors
("-prazole")

Potassium-competitive
acid blockers ("-prazan")

Others

Combinations

See also: Helicobacter pylori eradication protocols

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

v t e Chalconoids and their glycosides
Chalconoids	Butein Isoliquiritigenin Methyl hydroxychalcone Okanin
Chalconoid glycosides	Carthamin Marein okanin 3,4,3′-trimethyl ether 4′-glucoside okanin 4-methyl ether 4′-glucoside okanin 4-methyl ether 4′-glucoside monoacetate Okanin 3,4-dimethyl ether 4′-glucoside
Acylated chalconoids	Licochalcone A Sophoradin (prenylated) Tephrospinosin (3′,5′-diisopentenyl-2′,4′-dihydroxychalcone) (prenylated) Xanthohumol (prenylated)
O-methylated chalconoids	Cardamomin Flavokawin B Okanin 3,4,3′,4′-tetramethyl ether Pashanone (2',6'-Dihydroxy-3',4'-dimethoxychalcone)
Flavokavains	Flavokavain A Flavokavain B Flavokavain C
Synthetic	Sofalcone