KCNK6

Protein-coding gene in humans
KCNK6
Identifiers
AliasesKCNK6, K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2, potassium two pore domain channel subfamily K member 6
External IDsOMIM: 603939; MGI: 1891291; HomoloGene: 31266; GeneCards: KCNK6; OMA:KCNK6 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for KCNK6
Genomic location for KCNK6
Band19q13.2Start38,319,845 bp[1]
End38,332,076 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for KCNK6
Genomic location for KCNK6
Band7 B1|7 16.94 cMStart28,921,351 bp[2]
End28,931,940 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • decidua

  • ectocervix

  • monocyte

  • right coronary artery

  • ascending aorta

  • myometrium

  • mucosa of transverse colon

  • vagina

  • smooth muscle tissue

  • parotid gland
Top expressed in
  • fossa

  • skin of abdomen

  • right lobe of liver

  • epithelium of stomach

  • Paneth cell

  • parotid gland

  • condyle

  • belly cord

  • calvaria

  • left colon
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • inward rectifier potassium channel activity
  • voltage-gated ion channel activity
  • potassium channel activity
  • potassium ion leak channel activity
Cellular component
  • integral component of membrane
  • voltage-gated potassium channel complex
  • plasma membrane
  • membrane
  • integral component of plasma membrane
Biological process
  • regulation of resting membrane potential
  • potassium ion transport
  • regulation of ion transmembrane transport
  • cardiac conduction
  • ion transport
  • negative regulation of systemic arterial blood pressure
  • potassium ion transmembrane transport
  • regulation of systemic arterial blood pressure
  • stabilization of membrane potential
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9424

52150

Ensembl

ENSG00000099337

ENSMUSG00000046410

UniProt

Q9Y257

n/a

RefSeq (mRNA)

NM_004823

NM_001033525

RefSeq (protein)

NP_004814
NP_004814.1

n/a

Location (UCSC)Chr 19: 38.32 – 38.33 MbChr 7: 28.92 – 28.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.[5][6][7][8]

This gene encodes K2P6.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.[8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099337 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046410 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem. 274 (12): 7887–92. doi:10.1074/jbc.274.12.7887. PMID 10075682.
  6. ^ Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (3–4): 190–1. doi:10.1159/000015255. PMID 10393428. S2CID 84538070.
  7. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
  8. ^ a b "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6".

Further reading

  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
  • Mahboubi S, Kaufmann JH (1978). "Intramural duodenal hematoma in children. The role of the radiologist in its conservative management". Gastrointestinal Radiology. 1 (2): 167–71. doi:10.1007/BF02256360. PMID 1088718. S2CID 12318832.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Salinas M, Reyes R, Lesage F, et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.
  • Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, et al. (1999). "Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit". FEBS Lett. 450 (3): 191–6. doi:10.1016/S0014-5793(99)00495-0. PMID 10359073. S2CID 42980921.
  • Patel AJ, Maingret F, Magnone V, et al. (2000). "TWIK-2, an inactivating 2P domain K+ channel". J. Biol. Chem. 275 (37): 28722–30. doi:10.1074/jbc.M003755200. PMID 10887187.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mhatre AN, Li J, Chen AF, et al. (2004). "Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4". J. Neurosci. Res. 75 (1): 25–31. doi:10.1002/jnr.10839. PMID 14689445. S2CID 19133204.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl−: Chloride channel
H+: Proton channel
M+: CNG cation channel
M+: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders


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