KCND2

Protein-coding gene in the species Homo sapiens

KCND2

Identifiers

Aliases

KCND2, KV4.2, RK5, potassium voltage-gated channel subfamily D member 2

External IDs

OMIM: 605410; MGI: 102663; HomoloGene: 40828; GeneCards: KCND2; OMA:KCND2 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q31.31	Start	120,273,175 bp^[1]
Band	7q31.31	End	120,750,337 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6 A2- A3.1\|6 8.49 cM	Start	21,215,502 bp^[2]
Band	6 A2- A3.1\|6 8.49 cM	End	21,729,804 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cerebellar vermis

pons

stromal cell of endometrium

Brodmann area 23

prefrontal cortex

ganglionic eminence

Region I of hippocampus proper

endothelial cell

caudate nucleus

dorsolateral prefrontal cortex

Top expressed in

habenula

cerebellar vermis

medial geniculate nucleus

medial dorsal nucleus

third toe

olfactory tubercle

nucleus accumbens

lateral geniculate nucleus

globus pallidus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	potassium channel activity metal ion binding voltage-gated ion channel activity ion channel activity protein binding A-type (transient outward) potassium channel activity voltage-gated potassium channel activity voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
Cellular component	integral component of membrane perikaryon postsynaptic membrane cell projection membrane plasma membrane raft intrinsic component of plasma membrane voltage-gated potassium channel complex plasma membrane dendritic spine synapse integral component of plasma membrane neuronal cell body membrane cell junction neuronal cell body dendrite glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of postsynaptic specialization membrane postsynaptic density
Biological process	chemical synaptic transmission regulation of ion transmembrane transport ion transport potassium ion transport transmembrane transport potassium ion transmembrane transport action potential sensory perception of pain protein homooligomerization cellular response to hypoxia neuronal action potential locomotor rhythm regulation of postsynaptic membrane potential cardiac conduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3751


16508

Ensembl


ENSG00000184408


ENSMUSG00000060882

UniProt


Q9NZV8


Q9Z0V2

RefSeq (mRNA)


NM_012281


NM_019697

RefSeq (protein)


NP_036413


NP_062671

Location (UCSC)

Chr 7: 120.27 – 120.75 Mb

Chr 6: 21.22 – 21.73 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily D member 2 is a protein that in humans is encoded by the KCND2 gene.^[5]^[6]^[7] It contributes to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.^[8]

Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.^[7]

Interactions

KCND2 has been shown to interact with FLNC.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184408 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060882 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhu XR, Wulf A, Schwarz M, Isbrandt D, Pongs O (December 1999). "Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current". Receptors Channels. 6 (5): 387–400. PMID 10551270.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b "Entrez Gene: KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2".
^ Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–872. doi:10.1006/jmcc.2001.1376. PMID 11343410. S2CID 829154.
^ Petrecca, K; Miller D M; Shrier A (December 2000). "Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin". J. Neurosci. 20 (23): 8736–44. doi:10.1523/JNEUROSCI.20-23-08736.2000. PMC 6773047. PMID 11102480.

External links

Kv4.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCND2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

PDB gallery

1nn7: Crystal Structure Of The Tetramerization Domain Of The Shal Voltage-Gated Potassium Channel
1s6c: Crystal structure of the complex between KChIP1 and Kv4.2 N1-30

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin