Α-Neoendorphin

α-Neoendorphin
Names

Other names Alpha-Neoendorphin
Identifiers
CAS Number	69671-17-6
3D model (JSmol)	Interactive image
ChEBI	CHEBI:80261
ChEMBL	ChEMBL2409222
ChemSpider	4470544
IUPHAR/BPS	1600
KEGG	C16039
PubChem CID	5311003
CompTox Dashboard (EPA)	DTXSID701029640
InChI InChI=1S/C60H89N15O13/c1-36(2)30-46(73-56(84)47(32-37-12-4-3-5-13-37)69-51(79)35-67-50(78)34-68-52(80)42(63)31-38-18-22-40(76)23-19-38)55(83)71-44(16-10-28-66-60(64)65)53(81)70-43(14-6-8-26-61)54(82)74-48(33-39-20-24-41(77)25-21-39)58(86)75-29-11-17-49(75)57(85)72-45(59(87)88)15-7-9-27-62/h3-5,12-13,18-25,36,42-49,76-77H,6-11,14-17,26-35,61-63H2,1-2H3,(H,67,78)(H,68,80)(H,69,79)(H,70,81)(H,71,83)(H,72,85)(H,73,84)(H,74,82)(H,87,88)(H4,64,65,66)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1 Key: KZTDMJBCZSGHOG-XJIZABAQSA-N
SMILES N[C@@H](CC1=CC=C(O)C=C1)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=C(O)C=C3)C(N4CCC[C@H]4C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O
Properties
Chemical formula	C₆₀H₈₉N₁₅O₁₃
Molar mass	1228.464 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

α-Neoendorphin is an endogenous opioid peptide with a decapeptide structure and the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys.^[1]

α-Neoendorphin is a neuropeptide. Prodynorphin or Proenkephalin B is its precursor. Researchers and anatomists have not yet studied the distribution of α-neoendorphin in the human in detail. However, some studies have been done which supports the presence of α-neoendorphin immunoreactive fibers throughout the human brainstem. According to a study done by Duque, Ewing, Arturo Mangas, Pablo Salinas, Zaida Díaz-cabiale, José Narváez, and Rafael Coveñas; α-neoendorphin immunoreactive fibers can be found in the caudal part of the solitary nucleus, in the caudal and the gelatinosa parts of the spinal trigeminal nucleus, and only low density was found in the central grey matter of medulla.^[2]

References

^ Kangawa K.; Minamino N.; Chino N (1981). "The complete amino acid sequence of α-neo-endorphin". Biochemical and Biophysical Research Communications. 99 (3): 871–878. doi:10.1016/0006-291X(81)91244-4. PMID 7247946.
^ Duque, Ewing; Mangas, Arturo; Salinas, Pablo; Díaz-Cabiale, Zaida; Narváez, José Angel; Coveñas, Rafael (2012-02-09). "Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem". Brain Structure and Function. 218 (1): 131–149. doi:10.1007/s00429-012-0388-3. ISSN 1863-2653. PMID 22318412. S2CID 253974523.

Peptides: neuropeptides

Hormones

see hormones

Opioid peptides

Dynorphins	Dynorphin A Dynorphin A_1–8 Dynorphin B Big dynorphin Leumorphin α-Neoendorphin β-Neoendorphin
Endomorphins	Endomorphin-1 Endomorphin-2
Endorphins	α-Endorphin β-Endorphin γ-Endorphin
Enkephalins	Met-enkephalin Leu-enkephalin
Others	Adrenorphin Amidorphin Hemorphin Hemorphin-4 Nociceptin Opiorphin Spinorphin Valorphin

Other
neuropeptides

Kinins	Bradykinins Tachykinins: mammal Substance P Neurokinin A Neurokinin B amphibian Kassinin Physalaemin
Neuromedins	B N S U
Orexins	A B
Other	Angiotensin Bombesin Calcitonin gene-related peptide Carnosine Cocaine- and amphetamine-regulated transcript Delta-sleep-inducing peptide FMRFamide Galanin Galanin-like peptide Gastrin-releasing peptide Ghrelin Neuropeptide AF Neuropeptide FF Neuropeptide SF Neuropeptide VF Neuropeptide S Neuropeptide Y Neurophysins Neurotensin Pancreatic polypeptide Pituitary adenylate cyclase-activating peptide RVD-Hpα VGF