EGR3
| 早期生长应答蛋白3 Early growth response 3 | |||||||||||||
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| 标识 | |||||||||||||
| 代号 | EGR3; EGR-3; PILOT | ||||||||||||
| 扩展标识 | 遗传学：602419 鼠基因：1306780 同源基因：37923 GeneCards: EGR3 Gene | ||||||||||||
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| RNA表达模式 | |||||||||||||
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| 更多表达数据 | |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 1960 | 13655 | |||||||||||
| Ensembl | ENSG00000179388 | ENSMUSG00000033730 | |||||||||||
| UniProt | Q06889 | P43300 | |||||||||||
| mRNA序列 | NM_001199880 | NM_018781 | |||||||||||
| 蛋白序列 | NP_001186809 | NP_061251 | |||||||||||
| 基因位置 | Chr 8: 22.55 – 22.55 Mb | Chr 14: 70.08 – 70.08 Mb | |||||||||||
| PubMed查询 | [1] | [2] | |||||||||||
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早期生长反应蛋白3（英語：Early growth response protein 3，EGR-3）是一个由人类基因EGR3编码的蛋白质[1][2][3]。
该基因编码的蛋白为EGR家族的Cys2His2型锌指结构转录因子。这是一个是由有丝分裂刺激诱导的早期生长反应基因。由该基因编码的蛋白参与了控制生物节律的转录调控。它也可能在肌肉发育中起作用。[3]
参考文献
- ^ Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP. EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene. Aug 1991, 6 (6): 917–28. PMID 1906159.
- ^ Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD. HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter. J Biol Chem. May 2002, 277 (22): 19482–19487. PMID 11909874. doi:10.1074/jbc.M201687200.
- ^ 3.0 3.1 Entrez Gene: EGR3 early growth response 3. （原始内容存档于2019-10-16）.
延伸阅读
- Yamada K; Gerber DJ; Iwayama Y; et al. Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (8): 2815–2820. PMC 1815264
. PMID 17360599. doi:10.1073/pnas.0610765104. - Gerhard DS; Wagner L; Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–2127. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Yoo YG, Lee MO. Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor. J. Biol. Chem. 2004, 279 (35): 36242–36249. PMID 15173177. doi:10.1074/jbc.M401290200.
- Inoue A; Omoto Y; Yamaguchi Y; et al. Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells. J. Mol. Endocrinol. 2005, 32 (3): 649–661. PMID 15171706. doi:10.1677/jme.0.0320649.
- Liu D; Jia H; Holmes DI; et al. Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. Arterioscler. Thromb. Vasc. Biol. 2004, 23 (11): 2002–2007. PMID 14525795. doi:10.1161/01.ATV.0000098644.03153.6F.
- Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–16903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Tourtellotte WG, Milbrandt J. Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat. Genet. 1998, 20 (1): 87–91. PMID 9731539. doi:10.1038/1757.
- Morris ME; Viswanathan N; Kuhlman S; et al. A screen for genes induced in the suprachiasmatic nucleus by light. Science. 1998, 279 (5356): 1544–1547. PMID 9488654. doi:10.1126/science.279.5356.1544.
- Hillier LD; Lennon G; Becker M; et al. Generation and analysis of 280,000 human expressed sequence tags. Genome Res. 1997, 6 (9): 807–828. PMID 8889549. doi:10.1101/gr.6.9.807.
- Mages HW; Stamminger T; Rilke O; et al. Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells. Int. Immunol. 1993, 5 (1): 63–70. PMID 8443122. doi:10.1093/intimm/5.1.63.
外部链接
- 醫學主題詞表（MeSH）：EGR3+protein,+human
EGR3引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。
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