RoGEF domen
| RoGEF domen | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Struktura Dbl i plekstrin homolognih domena ljudskog proteina Son of sevenless.[1] | |||||||||
| Identifikatori | |||||||||
| Simbol | RhoGEF | ||||||||
| Pfam | PF00621 | ||||||||
| InterPro | IPR000219 | ||||||||
| SMART | RhoGEF | ||||||||
| SCOP | 1dbh | ||||||||
| SUPERFAMILY | 1dbh | ||||||||
| OPM protein | 1xd4 | ||||||||
| |||||||||
RoGEF domen je strukturni domen faktora razmene guanin nukleotida za Ro/Rac/Cdc42-slične GTPaze.[2] On se takođe naziva "Dbl-homologni" (DH) domen.[1]
Potfamilije
- Stimulator guanin-nukleotid disocijacije, CDC24 (IPR001331).
Zastupljenost
Sledeći ljudski proteini koji sadrže ovaj domen: ABR; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF3; ARHGEF4; ARHGEF5; ARHGEF6; ARHGEF7; ARHGEF9; ASEF2; BCR; C9orf100; DEPDC2; DNMBP; ECT2; FARP1; FARP2; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; GEFT; ITSN1; ITSN2; KALRN; LFDH; MCF2; MCF2L; MCF2L2; NET1; NGEF; OBSCN; PLEKHG1; PLEKHG2; PLEKHG3; PLEKHG4; PLEKHG5; PLEKHG6; PREX1; RASGRF1; SGEF; SOS1; SOS2; SPATA13; TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3;
Референце
- ^ а б Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J (1998). „Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein”. Cell. 95 (2): 259—68. PMID 9790532.
- ^ Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA (1991). „Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product”. Nature. 354 (6351): 311—4. PMID 1956381. doi:10.1038/354311a0.
Dodatna literatura
- Cerione RA, Zheng Y (1996). „The Dbl family of oncogenes”. Current Opinion in Cell Biology. 8 (2): 216—22. PMID 8791419.
- Tan EC, Leung T, Manser E, Lim L (1993). „The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins”. The Journal of Biological Chemistry. 268 (36): 27291—8. PMID 8262969.
