USP24

Protein-coding gene in the species Homo sapiens
USP24
Identifiers
AliasesUSP24, ubiquitin specific peptidase 24
External IDsOMIM: 610569; MGI: 1919936; HomoloGene: 35420; GeneCards: USP24; OMA:USP24 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for USP24
Genomic location for USP24
Band1p32.3Start55,066,359 bp[1]
End55,215,364 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for USP24
Genomic location for USP24
Band4|4 C7Start106,173,410 bp[2]
End106,298,519 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • Skeletal muscle tissue of rectus abdominis

  • biceps brachii

  • Skeletal muscle tissue of biceps brachii

  • gastrocnemius muscle

  • muscle of thigh

  • subcutaneous adipose tissue

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • Achilles tendon
Top expressed in
  • temporal muscle

  • digastric muscle

  • sternocleidomastoid muscle

  • triceps brachii muscle

  • muscle of thigh

  • soleus muscle

  • ankle

  • quadriceps femoris muscle

  • Paneth cell

  • gastrocnemius muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • peptidase activity
  • cysteine-type peptidase activity
  • hydrolase activity
  • thiol-dependent deubiquitinase
  • cysteine-type endopeptidase activity
Cellular component
  • nucleoplasm
  • cytoplasm
Biological process
  • ubiquitin-dependent protein catabolic process
  • proteolysis
  • protein deubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23358

329908

Ensembl

ENSG00000162402

ENSMUSG00000028514

UniProt

Q9UPU5

B1AY13

RefSeq (mRNA)

NM_015306

NM_183225

RefSeq (protein)

NP_056121

NP_899048

Location (UCSC)Chr 1: 55.07 – 55.22 MbChr 4: 106.17 – 106.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 24 is an enzyme that in humans is encoded by the USP24 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162402 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028514 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ "Entrez Gene: USP24 ubiquitin specific peptidase 24".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Li Y, Schrodi S, Rowland C, et al. (2006). "Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease". Hum. Mutat. 27 (10): 1017–23. doi:10.1002/humu.20382. PMID 16917932. S2CID 43881832.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.


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