UHRF2

Protein-coding gene in the species Homo sapiens


UHRF2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WY8, 1Z6U, 2E6S, 3OLN, 4PW5, 4PW6, 4PW7, 4TVR

Identifiers
AliasesUHRF2, NIRF, RNF107, URF2, TDRD23, ubiquitin like with PHD and ring finger domains 2
External IDsOMIM: 615211; MGI: 1923718; HomoloGene: 17001; GeneCards: UHRF2; OMA:UHRF2 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for UHRF2
Genomic location for UHRF2
Band9p24.1Start6,413,151 bp[1]
End6,507,054 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for UHRF2
Genomic location for UHRF2
Band19|19 C1Start30,007,913 bp[2]
End30,071,122 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • pancreatic epithelial cell

  • Achilles tendon

  • tibia

  • thymus

  • sperm

  • ventricular zone

  • germinal epithelium

  • bone marrow

  • bone marrow cells
Top expressed in
  • superior cervical ganglion

  • hand

  • tail of embryo

  • ventricular zone

  • genital tubercle

  • primitive streak

  • lens

  • neural layer of retina

  • epiblast

  • thymus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • histone binding
  • protein binding
  • metal ion binding
  • ubiquitin protein ligase activity
  • ubiquitin-protein transferase activity
  • transferase activity
  • SUMO transferase activity
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • protein autoubiquitination
  • regulation of DNA methylation-dependent heterochromatin assembly
  • cell cycle
  • cell differentiation
  • cell population proliferation
  • maintenance of DNA methylation
  • protein ubiquitination
  • regulation of cell cycle
  • protein sumoylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

115426

109113

Ensembl

ENSG00000147854

ENSMUSG00000024817

UniProt

Q96PU4

Q7TMI3

RefSeq (mRNA)

NM_152896
NM_152306

NM_144873

RefSeq (protein)

NP_690856

NP_659122

Location (UCSC)Chr 9: 6.41 – 6.51 MbChr 19: 30.01 – 30.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.[5][6]

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147854 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024817 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation". Biochem Biophys Res Commun. 296 (3): 530–6. doi:10.1016/S0006-291X(02)00890-2. PMID 12176013.
  6. ^ a b "Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain". Oncogene. 23 (46): 7601–10. doi:10.1038/sj.onc.1208053. PMID 15361834. S2CID 21948278.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Li Y, Mori T, Hata H, et al. (2004). "NIRF induces G1 arrest and associates with Cdk2". Biochem. Biophys. Res. Commun. 319 (2): 464–8. doi:10.1016/j.bbrc.2004.04.190. PMID 15178429.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Mori T, Li Y, Hata H, Kochi H (2004). "NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein". FEBS Lett. 557 (1–3): 209–14. doi:10.1016/S0014-5793(03)01495-9. PMID 14741369. S2CID 10006213.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • v
  • t
  • e
  • 1wy8: Solution Structure of the N-terminal Ubiquitin-like Domain in Human Np95/ICBP90-like Ring Finger Protein (NIRF)
    1wy8: Solution Structure of the N-terminal Ubiquitin-like Domain in Human Np95/ICBP90-like Ring Finger Protein (NIRF)
  • 1z6u: Np95-like ring finger protein isoform b [Homo sapiens]
    1z6u: Np95-like ring finger protein isoform b [Homo sapiens]


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