Tilorone

Chemical compound
  • J05AX19 (WHO)
Pharmacokinetic dataBioavailability60%Protein binding~80%MetabolismNilElimination half-life48 hoursExcretionFeces (70%), urine (9%)[1]Identifiers
  • 2,7-Bis(2-diethylaminoethoxy)fluoren-9-one
CAS Number
  • 27591-97-5 checkY
PubChem CID
  • 5475
ChemSpider
  • 5276 ☒N
UNII
  • O6W7VEW6KS
KEGG
  • D06149 ☒N
ChEBI
  • CHEBI:147347
ChEMBL
  • ChEMBL47298 ☒N
CompTox Dashboard (EPA)
  • DTXSID1045958 Edit this at Wikidata
Chemical and physical dataFormulaC25H34N2O3Molar mass410.558 g·mol−13D model (JSmol)
  • Interactive image
  • CCN(CC)CCOc1ccc-2c(c1)C(=O)c3c2ccc(c3)OCCN(CC)CC
InChI
  • InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3 ☒N
  • Key:MPMFCABZENCRHV-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Tilorone (trade names Amixin, Lavomax and others) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer.[2] It is used as an antiviral drug in some countries which do not require double-blind placebo-controlled studies, including Russia. It is effective against Ebola virus in mice.[3]

Pharmacology

Tilorone activates the production of interferon.[2]

References

  1. ^ "Registry of Medicinal Products (RLS). Tilorone: Prescribing Information" (in Russian). Retrieved 2 October 2016.
  2. ^ a b Stringfellow DA, Glasgow LA (August 1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrobial Agents and Chemotherapy. 2 (2): 73–78. doi:10.1128/aac.2.2.73. PMC 444270. PMID 4670490.
  3. ^ Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, et al. (February 2018). "Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection". Antimicrobial Agents and Chemotherapy. 62 (2). doi:10.1128/AAC.01711-17. PMC 5786809. PMID 29133569.
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