TMPRSS6

Protein-coding gene in the species Homo sapiens
TMPRSS6
Identifiers
AliasesTMPRSS6, IRIDA, transmembrane protease, serine 6, matriptase-2, transmembrane serine protease 6
External IDsOMIM: 609862; MGI: 1919003; HomoloGene: 12408; GeneCards: TMPRSS6; OMA:TMPRSS6 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for TMPRSS6
Genomic location for TMPRSS6
Band22q12.3Start37,065,436 bp[1]
End37,109,563 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for TMPRSS6
Genomic location for TMPRSS6
Band15|15 E1Start78,323,867 bp[2]
End78,352,834 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • lactiferous duct

  • pancreatic ductal cell

  • pituitary gland

  • anterior pituitary

  • right testis

  • cardia

  • left testis

  • putamen

  • secondary oocyte
Top expressed in
  • left lobe of liver

  • otolith organ

  • utricle

  • olfactory epithelium

  • gallbladder

  • vestibular sensory epithelium

  • vestibular membrane of cochlear duct

  • embryo

  • embryo

  • temporal muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • serine-type peptidase activity
  • peptidase activity
  • protein binding
  • hydrolase activity
  • serine-type endopeptidase activity
  • metalloendopeptidase activity
Cellular component
  • membrane
  • integral component of membrane
  • intracellular anatomical structure
  • extracellular space
  • plasma membrane
Biological process
  • membrane protein proteolysis
  • intracellular signal transduction
  • angiogenesis
  • fibrinolysis
  • negative regulation of BMP signaling pathway
  • self proteolysis
  • extracellular matrix organization
  • negative regulation of transcription, DNA-templated
  • proteolysis
  • cellular iron ion homeostasis
  • iron ion homeostasis
  • negative regulation of transcription by RNA polymerase II
  • positive regulation of transcription by RNA polymerase II
  • extracellular matrix disassembly
  • collagen catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

164656

71753

Ensembl

ENSG00000187045

ENSMUSG00000016942

UniProt

Q8IU80

Q9DBI0

RefSeq (mRNA)

NM_001289000
NM_001289001
NM_153609

NM_027902
NM_001355601

RefSeq (protein)

NP_001275929
NP_001275930
NP_705837
NP_001361433

NP_082178
NP_001342530

Location (UCSC)Chr 22: 37.07 – 37.11 MbChr 15: 78.32 – 78.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane protease, serine 6 (also known as matriptase-2) is an enzyme that in humans is encoded by the TMPRSS6 gene.[5]

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187045 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016942 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TMPRSS6 transmembrane protease, serine 6".

Further reading

  • Netzel-Arnett S, Hooper JD, Szabo R, et al. (2004). "Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer". Cancer Metastasis Rev. 22 (2–3): 237–58. doi:10.1023/A:1023003616848. PMID 12784999. S2CID 21824244.
  • Ramsay AJ, Reid JC, Velasco G, et al. (2007). "The type II transmembrane serine protease matriptase-2--identification, structural features, enzymology, expression pattern and potential roles" (PDF). Front. Biosci. 13 (13): 569–79. doi:10.2741/2702. PMID 17981570. S2CID 5578120.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Velasco G, Cal S, Quesada V, et al. (2002). "Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins". J. Biol. Chem. 277 (40): 37637–46. doi:10.1074/jbc.M203007200. PMID 12149247.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Hartikainen JM, Tuhkanen H, Kataja V, et al. (2006). "Refinement of the 22q12-q13 breast cancer--associated region: evidence of TMPRSS6 as a candidate gene in an eastern Finnish population". Clin. Cancer Res. 12 (5): 1454–62. doi:10.1158/1078-0432.CCR-05-1417. PMID 16533768.
  • Parr C, Sanders AJ, Davies G, et al. (2007). "Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients". Clin. Cancer Res. 13 (12): 3568–76. doi:10.1158/1078-0432.CCR-06-2357. PMID 17575220.
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